Copper(II) directs formation of toxic amorphous aggregates resulting in inhibition of hen egg white lysozyme fibrillation under alkaline salt-mediated conditions

Journal of Biomolecular Structure and Dynamics

Volumn 33, Issue 5, 2015, Pages 991-1007

  Ghosh, Sudeshna ^a   Pandey, Nitin K ^a   Banerjee, Priyanka ^a   Chaudhury, Koel ^a   Nagy, Nóra Veronika ^b   Dasgupta, Swagata ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Cu(II) stoichiometry; cytotoxicity; fibrillation; hen egg white lysozyme; inhibition; molten globule state

Indexed keywords

AMYLOID; COPPER; EGG WHITE; LYSOZYME; SODIUM CHLORIDE; THIOFLAVINE; HEN EGG LYSOZYME; PROTEIN AGGREGATE; PROTEIN BINDING;

ALKALINITY; ANIMAL CELL; ARTICLE; BETA SHEET; BINDING KINETICS; CELL PROLIFERATION; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; ELECTRON SPIN RESONANCE; FIBROBLAST; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; HYDROPHOBICITY; INHIBITION KINETICS; MOUSE; MTT ASSAY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; SPECIES DIFFERENCE; STOICHIOMETRY; TEMPERATURE; TURBIDITY; 3T3 CELL LINE; ANIMAL; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; CHICKEN; DRUG EFFECTS; FEMALE; METABOLISM; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AMYLOID; ANIMALS; CELL SURVIVAL; CHICKENS; CIRCULAR DICHROISM; COPPER; ELECTRON SPIN RESONANCE SPECTROSCOPY; FEMALE; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MURAMIDASE; NIH 3T3 CELLS; PROTEIN AGGREGATES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SODIUM CHLORIDE; TEMPERATURE;

EID: 84923638331     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2014.921864     Document Type: Article

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