Monitoring and delivery of sedation

British Journal of Anaesthesia

Volumn 113, Issue , 2014, Pages ii37-ii47

  Sheahan, C G ^b   Mathews, D M ^a  

^a Department of Anesthesiology ^*  (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

computer assisted infusion; drug interactions; monitoring, depth of anaesthesia; monitoring, ventilation; sedation

Indexed keywords

DEXMEDETOMIDINE; KETAMINE; PROPOFOL; HYPNOTIC SEDATIVE AGENT;

ANESTHESIA LEVEL; ANESTHESIST; ARTICLE; ARTIFICIAL VENTILATION; CAPNOMETRY; DRUG DELIVERY SYSTEM; DRUG MONITORING; ELECTROENCEPHALOGRAPHY; FOOD AND DRUG ADMINISTRATION; HUMAN; LUNG EXAMINATION; PATIENT CARE; PATIENT CONTROLLED ANALGESIA; PATIENT SATISFACTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; PULSE OXIMETRY; RESPIRATORY ACOUSTICAL MONITORING; SEDATION; THORACIC IMPEDANCE MONITORING; TRAINING; TRANSCUTANEOUS CARBON DIOXIDE MONITORING; UNITED STATES; ADVERSE EFFECTS; CONSCIOUS SEDATION; DRUG ADMINISTRATION; PHYSIOLOGIC MONITORING; PROCEDURES; STANDARDS;

CONSCIOUS SEDATION; DRUG ADMINISTRATION SCHEDULE; DRUG DELIVERY SYSTEMS; HUMANS; HYPNOTICS AND SEDATIVES; MONITORING, PHYSIOLOGIC; PRACTICE GUIDELINES AS TOPIC; PROPOFOL;

EID: 84923608499     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeu378     Document Type: Article

References (119)

1. Bailey PL, Pace NL, Ashburn MA, Moll JW, East KA, Stanley TH. Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. Anesthesiology 1990; 73: 826-30
2. New York Times. Joan Rivers, a comic stiletto quick to skewer, is dead at 81. Available from http://www.nytimes.com/2014/09/05/arts/television/joan-rivers-dies.html?-r=0 (accessed 13 September 2104
3. Bhananker SM, PosnerKL, CheneyFW,Caplan RA, Lee LA, DominoKB. Injury and liability associated with monitored anesthesia care: a closed claims analysis. Anesthesiology 2006; 104: 228-34
4. American Society ofAnesthesiologists. Standards for basicanesthetic monitoring. Available from http://www.asahq.org/for-members/media/For%20Members/documents/Standards%20Guidelines%20Stmts/Basic%20Anesthetic%20Monitoring%202011.ashx (accessed 13 August 2014
5. Academy of Medical Royal Colleges. Safe sedation practice for healthcare procedures, standards and guidance. Available from http://www.rcoa.ac.uk/system/files/PUB-SafeSedPrac2013. pdf (accessed 16 August 2014
6. Knape JT, Adriaensen H, van Aken H, et al. Guidelines for sedation and/oranalgesia bynon-Anaesthesiology doctors. Eur J Anaesthesiol 2007; 24: 563-67
7. The ESATask Force on Sedation. Available fromhttp://www.esahq. org/about-us/the-esa/committees/guidelines-committee/taskforce-on-sedation (accessed 18 August 2014
8. Australian and New Zealand College of Anaesthetists (ANZCA). Guidelines on sedation and/or analgesia for diagnostic and interventional medical, dental or surgical procedures. Available from http://www.anzca.edu.au/resources/professional-documents/pdfs/ps09-2014-guidelines-on-sedation-And-or-Analgesia-for-diagnostic-And-interventional-medical-dental-or-surgical-procedures.pdf (accessed 16 August 2014
9. Mason KP, Green SM, Piacevoli Q, International Sedation Task Force. Adverse event reporting tool to standardize the reporting and tracking of adverse events during procedural sedation: a consensus document from the World SIVA International Sedation Task Force. Br J Anaesth 2012; 108: 13-20
10. NewsteadB, BradburnS, AppelboamA, et al. Propofol foradult procedural sedation in a UK emergency department: safety profile in 1008 cases. Br J Anaesth 2013; 111: 651-5
11. American Society of Anesthesiologists. Continuum of depth of sedation. Available from http://www.asahq.org/for-members/media/For%20Members/documents/Standards%20Guidelines%20Stmts/Continuum%20of%20Depth%20of%20Sedation.ashx (accessed 18 August 2014
12. Chernik DA, Gillings D, Laine H, et al. Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: study with intravenousmidazolam. J Clin Psychopharmacol 1990;10:244-51
13. Gill M, Green SM, Krauss B. A study of the bispectral index monitor during procedural sedation and analgesia in the emergency department. Ann Emerg Med 2003; 41: 234-41
14. Ramsay MA, Savege TM, Simpson BR, Goodwin R. Controlled sedation with alphaxalone-Alphadolone. Br Med J 1974; 2: 656-9
15. Glass PS, Bloom M, Kearse L, Rosow C, Sebel P, Manberg P. Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers. Anesthesiology 1997; 86: 836-47
16. Kasuya Y, Govinda R, Rauch S, Mascha EJ, Sessler DI, Turan A. The correlation between bispectral index and observational sedation scale in volunteers sedated with dexmedetomidine and propofol. Anesth Analg 2009; 109: 1811-5
17. Bower AL, Ripepi A, Dilger J, Boparai N, Brody FJ, Ponsky JL. Bispectral index monitoring of sedation during endoscopy. Gastrointest Endosc 2000; 52: 192-6
18. von Delius S, Thies P, Rieder T, et al. Auditory evoked potentials comparedwith bispectral index formonitoring ofmidazolamandpropofol sedation during colonoscopy. Am J Gastroenterol 2009; 104: 318-25
19. Sandler NA, Sparks BS. The use of bispectral analysis in patients undergoing intravenous sedation for third molar extractions. J Oral Maxillofac Surg 2000; 58: 364-8
20. Weaver CS, Hauter WH, Duncan CE, Brizendine EJ, Cordell WH. An assessment of the association of bispectral index with 2 clinical sedation scales for monitoring depth of procedural sedation. Am J Emerg Med 2007; 25: 918-24
21. Ibrahim AE, Taraday JK, Kharasch ED. Bispectral index monitoring during sedation with sevoflurane, midazolam,andpropofol. Anesthesiology 2001; 95: 1151-9
22. Chisholm CJ, Zurica J, Mironov D, Sciacca RR, Ornstein E, Heyer EJ. Comparison of electrophysiologic monitors with clinical assessment of level of sedation. Mayo Clin Proc 2006; 81: 46-52
23. Fruchter O, Tirosh M, Carmi U, Rosengarten D, Kramer MR. Prospective randomized trial of bispectral index monitoring of sedation depth during flexible bronchoscopy. Respiration 2014; 87: 388-93
24. Drake LM, Chen SC, Rex DK. Efficacy of bispectral monitoring as an adjunct to nurse-Administered propofol sedation for colonoscopy: a randomized controlled trial. Am J Gastroenterol 2006; 101: 2003-7
25. Yu YH,HanDS, Kim HS, et al. Efficacy of bispectral index monitoring during balanced propofol sedation for colonoscopy: a prospective, randomized controlled trial. Dig Dis Sci 2013; 58: 3576-83
26. WehrmannT, GrotkampJ, Stergiou N, et al. Electroencephalogram monitoring facilitates sedation with propofol for routine ERCP: a randomized, controlled trial. Gastrointest Endosc 2002; 56: 817-24
27. Paspatis GA, Chainaki I, Manolaraki MM, et al. Efficacy of bispectral index monitoring as an adjunct to propofol deep sedation for ERCP:arandomizedcontrolled trial. Endoscopy2009;41:1046-51
28. von Delius S, Salletmaier H, Meining A, et al. Bispectral index monitoring of midazolam and propofol sedation during endoscopic retrograde cholangiopancreatography: a randomized clinical trial (the EndoBIS study). Endoscopy 2012; 44: 258-64
29. Yang KS, Habib AS, Lu M, et al. A prospective evaluation of the incidence of adverse events in nurse-Administered moderate sedation guided by sedation scores or Bispectral Index. Anesth Analg 2014; 119: 43-8
30. Doufas AG, Bakhshandeh M, Bjorksten AR, Greif R, Sessler DI. Automated responsiveness test (ART) predicts loss of consciousness and adverse physiologic responses during propofol conscious sedation. Anesthesiology 2001; 94: 585-92
31. Doufas AG, Morioka N, Mahgoub AN, Bjorksten AR, Shafer SL, Sessler DI. Automated responsiveness monitor to titrate propofol sedation. Anesth Analg 2009; 109: 778-86
32. Gerstenberger PD. Capnographyand patient safety forendoscopy. Clin Gastroenterol Hepatol 2010; 8: 423-5
33. SundmanE,Witt H, Sandin R, et al. Pharyngealfunctionandairway protection during subhypnotic concentrations of propofol, isoflurane, and sevoflurane: volunteers examined by pharyngeal videoradiography and simultaneous manometry. Anesthesiology 2001; 95: 1125-32
34. Hillman DR,Walsh JH, Maddison KJ, et al. Evolution of changes in upper airway collapsibility during slow induction of anesthesia with propofol. Anesthesiology 2009; 111: 63-71
35. Vargo JJ, Zuccaro G Jr., Dumot JA, Conwell DL, Morrow JB, Shay SS. Automated graphic assessment of respiratory activity is superior to pulse oximetry and visual assessment for the detection of early respiratory depression during therapeutic upper endoscopy. Gastrointest Endosc 2002; 55: 826-31
36. Tanaka PP, Tanaka M, Drover DR. Detection of respiratory compromise by acoustic monitoring, capnography, and brain function monitoring during monitored anesthesia care. J Clin Monit Comput Advance Access published on January 14, 2014
37. FuES,Downs JB,SchweigerJW, MiguelRV,SmithRA.Supplemental oxygen impairs detection of hypoventilation by pulse oximetry. CHEST 2004; 126: 1552-8
38. Arakawa H, Kaise M, Sumiyama K, Saito S, Suzuki T, Tajiri H. Does pulse oximetry accurately monitor a patient's ventilation during sedated endoscopy under oxygen supplementation? Singapore Med J 2013; 54: 212-5
39. Casati A, Gallioli G, Passaretta R, Scandroglio M, Bignami E, Torri G. End tidal carbon dioxide monitoring in spontaneously breathing, nonintubated patients. A clinical comparison between conventional sidestream and microstream capnometers. Minerva Anestesiol 2001; 67: 161-4
40. Lightdale JR,GoldmannDA, FeldmanHA,Newburg AR, DiNardoJA, Fox VL. Microstream capnography improves patient monitoring during moderate sedation: a randomized, controlled trial. Pediatrics 2006; 117: e1170-8
41. Cacho G, Pé rez-Calle JL, Barbado A, Lledó JL, Ojea R, Fernández-Rodŕguez CM. Capnography is superior to pulse oximetry for the detection of respiratory depression during colonoscopy. Rev Esp Enferm Dig 2010; 102: 86-9
42. Burton JH, Harrah JD, Germann CA, Dillon DC. Does end-tidal carbon dioxide monitoring detect respiratory events prior to current sedation monitoring practices? Acad Emerg Med 2006; 13: 500-4
43. Deitch K, Miner J, Chudnofsky CR, Dominici P, Latta D. Does end tidal CO2 monitoring during emergency department procedural sedation and analgesia with propofol decrease the incidence of hypoxic events? A randomized, controlled trial. Ann Emerg Med 2010; 55: 258-64
44. Qadeer MA, Vargo JJ, Dumot JA, et al. Capnographic monitoring of respiratory activity improves safety of sedation for endoscopic cholangiopancreatography and ultrasonography. Gastroenterology 2009; 136: 1568-76
45. Beitz A, Riphaus A, Meining A, et al. Capnographic monitoring reduces the incidence of arterial oxygen desaturation and hypoxemia during propofol sedation for colonoscopy: a randomized, controlled study (ColoCap Study). Am J Gastroenterol 2012; 107: 1205-12
46. Waugh JB, Epps CA, Khodneva YA. Capnography enhances surveillance of respiratory events during procedural sedation: a meta-Analysis. J Clin Anesth 2011; 23: 189-96
47. van Loon K, van Rheineck Leyssius AT, van Zaane B, Denteneer M, Kalkman CJ. Capnography during deep sedation with propofol by non-Anesthesiologists: a randomized controlled trial. Anesth Analg 2014; 119: 49-55
48. DeOliveira GS, Ahmad S, Fitzgerald PC, McCarthy RJ. Detection of hypoventilation during deep sedation in patients undergoing ambulatory gynaecological hysteroscopy: a comparison between transcutaneous and nasal end-tidal carbon dioxide measurements. Br J Anaesth 2010; 104: 774-8
49. Wilkinson JN, Thanawala VU. Thoracic impedance monitoring of respiratory rate during sedation-is it safe? Anaesthesia 2009; 64: 455-6
50. Voscopoulos C, Brayanov J, Ladd D, Lalli M, Panasyuk A, Freeman J. Special article: evaluation of a novel noninvasive respiration monitorproviding continuousmeasurementofminuteventilation in ambulatory subjects in a variety of clinical scenarios. Anesth Analg 2013; 117: 91-100
51. Goudra BG, Penugonda LC, Speck RM, Sinha AC. Comparison of acoustic respiration rate, impedance pneumography and capnometry monitors for respiration rate accuracy and apnea detection during GI endoscopy anesthesia. OJAnes 2013; 3: 74-9
52. Ramsay MA, Usman M, Lagow E, Mendoza M, Untalan E, De Vol E. The accuracy, precision and reliability of measuring ventilatory rate anddetecting ventilatorypause byrainbowacousticmonitoring and capnometry. Anesth Analg 2013; 117: 69-75
53. Yu L, Ting CK, Hill BE, et al. Using the entropy of tracheal sounds to detect apnea during sedation in healthy nonobese volunteers. Anesthesiology 2013; 118: 1341-9
54. Tatara T, Tsuzaki K. An apnea monitor using a rapid-response hygrometer. J Clin Monit 1997; 13: 5-9
55. Mason KP. Challenges in paediatric procedural sedation: political, economic, and clinical aspects. Br J Anaesth 2014; 113: ii48-ii62
56. Horiuchi A, NakayamaY, HidakaN, Ichise Y, KajiyamaM, TanakaN. Low-dose propofol sedation for diagnostic esophagogastroduodenoscopy: results in 10,662 adults. Am J Gastroenterol 2009; 104: 1650-5
57. Mertens MJ, Olofsen EM, Engbers FH, et al. Propofol reduces perioperative remifentanil requirements in a synergistic manner: response surface modeling of perioperative remifentanil-propofol Interactions. Anesthesiology 2003; 99: 347-59
58. Kern SE, Xie G, White JL, Egan TD. A response surface analysis of propofol-remifentanil pharmacodynamic interaction in volunteers. Anesthesiology 2004; 100: 1373-81
59. LaPierre CD, Johnson KB, Randall BR, White JL, Egan TD. An exploration of remifentanil-propofol combinations that lead to a loss of response to esophageal instrumentation, a loss of responsiveness, and/or onset of intolerable ventilatory depression. Anesth Analg 2011; 113: 490-9
60. Borrat X, Trocóniz IF, Valencia JF, et al. Modeling the influence of the A118G polymorphism in the OPRM1 gene and of noxious stimulation on the synergistic relation between propofol and remifentanil: sedation and analgesia in endoscopic procedures. Anesthesiology 2013; 118: 1395-407
61. Bennett J, Shafer DM, EfawD, Goupil M. Incremental bolus versus a continuous infusion of propofol for deep sedation/general anesthesia during dentoalveolar surgery. J Oral Maxillofac Surg 1998; 56: 1049-53
62. Brownlie GS, Baker JA, OggTW. Propofol: bolus or continuous infusion. A day case technique for the vaginal termination of pregnancy. Anaesthesia 1991; 46: 775-7
63. Grendelmeier P, Tamm M, Pflimlin E, Stolz D. Propofol sedation for flexible bronchoscopy: a randomised, noninferiority trial. Eur Respir J 2014; 43: 591-601
64. González-Santiago JM, Martn-Noguerol E, Vinagre-Rodŕguez G, et al. Intermittent boluses versus pump continuous infusion for endoscopist-directed propofol administration in colonoscopy. Rev Esp Enferm Dig 2013; 105: 378-84
65. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000; 93: 382-94
66. Scholz J, Tonner PH. a2-Adrenoceptor agonists in anaesthesia: a new paradigm. Curr Opin Anesthesiol 2000; 13: 437-42
67. Gupta P, Joshi S, JethavaD, Kumar A. Dexmedetomidine ameliorates monitored anaesthesia care. Indian J Anaesth 2014; 58: 154-9
68. Candiotti KA, Bergese SD, Bokesch PM, Feldman MA, WisemandleW, Bekker AY, MAC Study Group. Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial. Anesth Analg 2010; 110: 47-56
69. Alhashemi JA. Dexmedetomidine vs midazolam for monitored anaesthesiacare during cataract surgery. Br JAnaesth 2006; 96: 722-6
70. Jalowiecki P, Rudner R, Gonciarz M, Kawecki P, Petelenz M, Dziurdzik P. Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy. Anesthesiology 2005; 103: 269-73
71. Zeyneloglu P, Pirat A, Candan S, Kuyumcu S, Tekin I, Arslan G. Dexmedetomidine causes prolonged recovery when compared with midazolam/fentanyl combination in outpatient shock wave lithotripsy. Eur J Anaesthesiol 2008; 25: 961-7
72. Taghinia AH, Shapiro FE, Slavin SA. Dexmedetomidine in aesthetic facial surgery: improving anesthetic safety and efficacy. Plast Reconstr Surg 2008; 121: 269-76
73. ShenSL,ZhengJY,ZhangJ, et al.Comparisonofdexmedetomidine and propofol for conscious sedation in awake craniotomy: a prospective, double-blind, randomized, and controlled clinical trial. Ann Pharmacother 2013; 47: 1391-9
74. CheungCW, Ng KF, Liu J, Yuen MY, Ho MH, Irwin MG. Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia. Br J Anaesth 2011; 107: 430-7
75. White PF, Way WL, Trevor AJ. Ketamine-its pharmacology and therapeutic uses. Anesthesiology 1982; 56: 119-36
76. Green SM, Andolfatto G, Krauss B. Ketofol for procedural sedation? Pro and con. Ann Emerg Med 2011; 57: 444-8
77. Donnelly RF, Willman E, Andolfatto G. Stability of ketamine-propofol mixtures for procedural sedation and analgesia in the emergency department. Can J Hosp Pharm 2008; 61: 426-30
78. Arora S. Combining ketamine and propofol ("ketofol") for emergency department procedural sedation and analgesia: a review. West J Emerg Med 2008; 9: 20-3
79. David H, Shipp J.A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation. Ann Emerg Med 2011; 57: 435-41
80. Andolfatto G, Abu-Laban RB, Zed PJ, et al. Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial. Ann Emerg Med 2012; 59: 504-12
81. Dal T, Sazak H, Tunç M, Şahin Ş, Ylmaz A. A comparison of ketamine-midazolam and ketamine-propofol combinations used for sedation in the endobronchial ultrasoundguided transbronchial needle aspiration: a prospective, singleblind, randomized study. J Thorac Dis 2014; 6: 742-51
82. Friedberg BL. Propofol-ketamine technique: dissociative anesthesia for office surgery (a 5-year review of 1264 cases). Aesthetic Plast Surg 1999; 23: 70-5
83. Kogan A, Efrat R, Katz J, Vidne BA. Propofol-ketamine mixture for anesthesia in pediatric patients undergoing cardiac catheterization. J Cardiothorac Vasc Anesth 2003; 17: 691-3
84. Atkins JH, Mandel JE. Recent advances in patient-controlled sedation. Curr Opin Anaesthesiol 2008; 21: 759-65
85. Oei-Lim VL, Kalkman CJ, Makkes PC, Ooms WG. Patient-controlled versus anesthesiologist-controlled conscious sedation with propofol for dental treatment in anxious patients. Anesth Analg 1998; 86: 967-72
86. Herrick IA, GelbAW, Nichols B, Kirkby J. Patient-controlled propofol sedation for elderly patients: safety and patient attitude toward control. Can J Anaesth 1996; 43: 1014-8
87. Ekin A,Donmez F, TaspinarV,Dikmen B.Patient-controlled sedation inorthopedic surgeryunder regional anesthesia: a newapproachin procedural sedation. Braz J Anesthesiol 2013; 63: 410-4
88. Dell R, Cloote A. Patient-controlled sedation during transvaginal oocyte retrieval: an assessment of patient acceptance of patient-controlled sedation using a mixture of propofol and alfentanil. Eur J Anaesthesiol 1998; 15: 210-5
89. Bell A, Lipp T, Greenslade J, Chu K, Rothwell S, Duncan A. A randomized controlled trial comparing patient-controlled and physician-controlled sedation in the emergency department. Ann Emerg Med 2010; 56: 502-8
90. Mazanikov M,Udd M, KylänpaäL, et al. Patient-controlled sedation with propofol and remifentanil for ERCP: a randomized, controlled study. Gastrointest Endosc 2011; 73: 260-6
91. Mazanikov M,Udd M, KylänpaäL, et al. Patient-controlled sedation for ERCP: a randomized double-blind comparison of alfentanil and remifentanil. Endoscopy 2012; 44: 487-92
92. Mazanikov M, Udd M, KylänpaäL, et al. Dexmedetomidine impairs success of patient-controlled sedation in alcoholics during ERCP: a randomized, double-blind, placebo-controlled study. Surg Endosc 2013; 27: 2163-8
93. Mazanikov M, Udd M, KylänpaäL, et al. A randomized comparison of target-controlled propofol infusion and patient-controlled sedation during ERCP. Endoscopy 2013; 45: 915-9
94. Alhashemi JA, Kaki AM. Anesthesiologist-controlled versus patient-controlled propofol sedation for shockwave lithotripsy. Can J Anaesth 2006; 53: 449-55
95. Maurice-Szamburski A, Loundou A, Auquier P, Girard N, Bruder N. Effect of patient-controlled sedation with propofol on patient satisfaction: arandomizedstudy.AnnFrAnesthReanim2013;32:e171-5
96. Nilsson A, Steinvall I, Bak Z, Sjöberg F. Patient controlled sedation using a standard protocol for dressing changes in burns: Patients' preference, procedural details and a preliminary safety evaluation. Are studies always adequately powered and analyzed? Burns 2010; 36: 948-50
97. NgJM,KongCF,NyamD. Patient-controlled sedation with propofol for colonoscopy. Gastrointest Endosc 2001; 54: 8-13
98. Fanti L, Agostoni M, Casati A, et al. Target-controlled propofol infusion during monitored anesthesia in patients undergoing ERCP. Gastrointest Endosc 2004; 60: 361-6
99. Lin TY, Lo YL, Hsieh CH, et al. The potential regimen of targetcontrolled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial. PLoS One 2013; 8: e62744
100. Oei-Lim VL, Kalkman CJ, Makkes PC, Ooms WG, Hoogstraten J. Computer controlled infusion of propofol for conscious sedation in dental treatment. Br Dent J 1997; 183: 204-8
101. Chen L, Wang M, Xiang H, Lin X, Cao D, Ye L. Prediction of effect-site concentration of sufentanilby dose-response target controlled infusionof sufentanilandpropofol foranalgesicandsedation maintenance in burn dressing changes. Burns 2014; 40: 455-9
102. Yeganeh N, Roshani B, Azizi B, Almasi A. Target-controlled infusion of remifentanil to provide analgesia for awake nasotracheal fiberoptic intubations in cervical trauma patients. J Trauma 2010; 69: 1185-90
103. Moerman AT, Herregods LL, De Vos MM, Mortier EP, Struys MM. Manual versus target-controlled infusion remifentanil administration in spontaneously breathing patients. Anesth Analg 2009; 108: 828-34
104. Leslie K, Clavisi O, Hargrove J. Target-controlled infusion versus manually-controlled infusion of propofol for general anaesthesia or sedation in adults. Cochrane Database Syst Rev 2008; 3: CD006059
105. Sakaguchi M, Higuchi H, Maeda S, Miyawaki T. Dental sedation for patients with intellectual disability: a prospective study of manual control versus Bispectral Index-guided target-controlled infusion of propofol. J Clin Anesth 2011; 23: 636-42
106. Chiang MH, Wu SC, You CH, et al. Target-controlled infusion vs. manually controlled infusion of propofol with alfentanil for bidirectional endoscopy: a randomized controlled trial. Endoscopy 2013; 45: 907-14
107. Gillham MJ, Hutchinson RC, Carter R, Kenny GN. Patientmaintained sedation for ERCP with a target-controlled infusion of propofol: a pilot study. Gastrointest Endos 2001; 54: 14-7
108. Leitch JA, Sutcliffe N, Kenny GN. Patient-maintained sedation for oral surgery using a target-controlled infusion of propofol-A pilot study. Br Dent J 2003; 194: 43-5
109. Campbell L, Imrie G, Doherty P, et al. Patient maintained sedation for colonoscopy using a target controlled infusion of propofol. Anaesthesia 2004; 59: 127-32
110. Irwin MG, Thompson N, Kenny GN. Patient-maintained propofol sedation. Assessment of a target-controlled infusion system. Anaesthesia 1997; 52: 525-30
111. Stonell CA, Leslie K, Absalom AR. Effect-site targeted patientcontrolled sedation with propofol: comparison with anaesthetist administration for colonoscopy. Anaesthesia 2006; 61: 240-7
112. Maslekar S, Balaji P, Gardiner A, Culbert B, Monson JR, Duthie GS. Randomized controlled trial of patient-controlled sedation for colonoscopy: Entonox vs modified patient-maintained target-controlled propofol. Colorectal Dis 2011; 13: 48-57
113. Urman RD, Maurer WG. Computer computer-Assisted personalized sedation: friend or foe? Anesth Analg 2014; 119: 207-11
114. Pambianco DJ, Whitten CJ, Moerman A, Struys MM, Martin JF. An assessment of computer-Assisted personalized sedation: a sedation delivery system to administer propofol for gastrointestinal endoscopy. Gastrointest Endosc 2008; 68: 542-7
115. Pambianco DJ, Vargo JJ, Pruitt RE, Hardi R, Martin JF. Computerassisted personalized sedation for upper endoscopy and colonoscopy: a comparative, multicenter randomized study. Gastrointest Endosc 2011; 73: 765-72
116. Leslie K, Absalom A, Kenny GN. Closed loop control of sedation for colonoscopy using the Bispectral Index. Anaesthesia 2002; 57: 693-7
117. Sakai T,Matsuki A, White PF, Giesecke AH. Use of an EEG-bispectral closed-loop delivery system for administering propofol. Acta Anaesthesiol Scand 2000; 44: 1007-10
118. Gambús PL, JensenEW, Jospin M, et al. Modeling the effect of propofol and remifentanil combinations for sedation-Analgesia in endoscopic procedures using an Adaptive Neuro Fuzzy Inference System (ANFIS). Anesth Analg 2011; 112: 331-9
119. Luginbühl M, Schumacher PM, Vuilleumier P, et al. Noxious stimulation response index: a novel anesthetic state index based on hypnotic-opioid interaction. Anesthesiology 2010; 112: 872-80