Opioid-hypnotic synergy: A response surface analysis of propofol-remifentanil pharmacodynamic interaction in volunteers

Anesthesiology

Volumn 100, Issue 6, 2004, Pages 1373-1381

  Kern, Steven E ^a,c   Xie, Guoming ^b   White, Julia L ^c   Egan, Talmage D ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c Department of Pharmaceutics ^*

Author keywords

[No Author keywords available]

Indexed keywords

HYPNOTIC SEDATIVE AGENT; OPIATE; PROPOFOL; REMIFENTANIL; NARCOTIC AGENT; PIPERIDINE DERIVATIVE;

ADULT; ALERTNESS; ANESTHESIA MECHANISM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CROSS REACTIVITY; DRUG DETERMINATION; DRUG EFFECT; FEMALE; GRECO INTERACTION MODEL; HUMAN; HUMAN EXPERIMENT; HYPNOSIS; MALE; MATHEMATICAL MODEL; NOCICEPTIVE STIMULATION; NORMAL HUMAN; PRESSURE MEASUREMENT; PRIORITY JOURNAL; RESPONSE SURFACE ANALYSIS; SCORING SYSTEM; SEDATION; STIMULUS RESPONSE; SURFACE PROPERTY; TETANY; TIBIA; VALIDATION PROCESS; ADOLESCENT; BIOLOGICAL MODEL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DOSE RESPONSE; DRUG COMBINATION; DRUG INTERACTION; DRUG POTENTIATION; LARYNGOSCOPY; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG INTERACTIONS; DRUG SYNERGISM; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; LARYNGOSCOPY; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NARCOTICS; PIPERIDINES; PROPOFOL;

EID: 2542491044     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200406000-00007     Document Type: Article

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