Analysis of the resistance of hepatitis C virus NS5B polymerase inhibitors via docking and molecular dynamics simulation

Molecular Informatics

Volumn 34, Issue 2-3, 2015, Pages 78-83

  Uengwetwanit, Tanaporn ^a   Robaa, Dina ^a   Sippl, Wolfgang ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Binding free energy; Hepatitis; MM GB SA; Mutation; NS5B polymerase

Indexed keywords

AMIDE; BENZIMIDAZOLE DERIVATIVE; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 5B; NONSTRUCTURAL PROTEIN 5B INHIBITOR; RNA DIRECTED RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; ENZYME INHIBITOR; NS-5 PROTEIN, HEPATITIS C VIRUS; VIRAL PROTEIN;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HEPATITIS C VIRUS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; WILD TYPE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYMOLOGY; GENETICS; HEPACIVIRUS; HUMAN; MUTATION;

HEPATITIS C VIRUS;

ANTIVIRAL AGENTS; BENZIMIDAZOLES; ENZYME INHIBITORS; HEPACIVIRUS; HUMANS; MUTATION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84923567004     PISSN: 18681743     EISSN: 18681751     Source Type: Journal    
DOI: 10.1002/minf.201400048     Document Type: Article

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