A hotspot in the glucocorticoid receptor DNA-binding domain susceptible to loss of function mutation

Steroids

Volumn 96, Issue , 2015, Pages 115-120

  Banuelos, Jesus ^a   Shin, Soon Cheon ^a   Lu, Nick Z ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Glucocorticoid; Glucocorticoid receptor; Glucocorticoid receptor mutation; Glucocorticoid resistance

Indexed keywords

ANDROGEN RECEPTOR; ARGININE; CELL NUCLEUS RECEPTOR; CYSTEINE; DEXAMETHASONE; DNA; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; LUCIFERASE; MINERALOCORTICOID RECEPTOR; TRANSCRIPTION FACTOR AP 1; ZINC FINGER PROTEIN; MUTANT PROTEIN;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHROMOSOME 18; CONTROLLED STUDY; CYTOPLASM; DNA BINDING; DRUG RESISTANCE; GENE CONTROL; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNOHISTOCHEMISTRY; JURKAT CELL LINE; LIGAND BINDING; LOSS OF FUNCTION MUTATION; LUCIFERASE ASSAY; MOUSE; MUTANT; NONHUMAN; POINT MUTATION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; STABLE EXPRESSION; START CODON; THYMOMA; THYMOMA CELL LINE; TRANSACTIVATION; TRANSIENT TRANSFECTION; UPREGULATION; WILD TYPE; ZYGOSITY; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN TERTIARY STRUCTURE; RAT; TUMOR CELL LINE;

MOUSE MAMMARY TUMOR VIRUS;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; DNA; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTION, GENETIC;

EID: 84923542543     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2015.01.022     Document Type: Article

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