Brain delivery of intranasal in situ gel of nanoparticulated polymeric carriers containing antidepressant drug: Behavioral and biochemical assessment

Journal of Drug Targeting

Volumn 23, Issue 3, 2015, Pages 275-286

  Kaur, Prabhjot ^a   Garg, Tarun ^a   Vaidya, Bhuvaneshwar ^a   Prakash, Atish ^a   Rath, Goutam ^a   Goyal, Amit K ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

Brain delivery; Depression; Intranasal drug delivery; Nanoparticles; Tramadol HCl

Indexed keywords

CATALASE; CHITOSAN NANOPARTICLE; DRUG CARRIER; GLUTATHIONE; MALONALDEHYDE; NITRITE; POLOXAMER; SUCROSE; TRAMADOL; ANTIDEPRESSANT AGENT; GEL; NANOPARTICLE; POLYMER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BIOCHEMISTRY; BODY WEIGHT; CONTROLLED STUDY; DEPRESSION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG ENTRAPMENT EFFICIENCY; DRUG RELEASE; FEMALE; FORCED SWIM TEST; GEL; GELATION; IMMOBILITY; IONIC GELATION; LIPID PEROXIDATION; LOCOMOTION; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; RAT; SUGAR INTAKE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; BRAIN; CHEMISTRY; DRUG EFFECTS; INTRANASAL DRUG ADMINISTRATION; METABOLISM; MOTOR ACTIVITY; TONIC IMMOBILITY;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIDEPRESSIVE AGENTS; BODY WEIGHT; BRAIN; CATALASE; DRUG CARRIERS; FEMALE; GELS; GLUTATHIONE; IMMOBILITY RESPONSE, TONIC; MOTOR ACTIVITY; NANOPARTICLES; NITRITES; POLYMERS; RATS; TRAMADOL;

EID: 84923370916     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2014.994097     Document Type: Article

References (45)

1. Yu ZF, Kong LD, Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. J Ethnopharmacol 2002;83: 161-5.
2. Sharma R, Singh H, Joshi M, et al. Recent advances in polymeric electrospun nanofibers for drug delivery. Crit Rev Ther Drug Carrier Syst 2014b;31:187-217.
3. Sharma A, Garg T, Aman A, et al. Nanogel-an advanced drug delivery tool: current and future. Artif Cells Nanomed Biotechnol 2014a;1-13.
4. Rohilla R, Garg T, Goyal AK, Rath G. Herbal and polymeric approaches for liver-targeting drug delivery: novel strategies and their significance. Drug Deliv 2014;1-17.
5. Morie A, Garg T, Goyal AK, Rath G. Nanofibers as novel drug carrier-an overview. Artif Cells Nanomed Biotechnol 2014;1-9.
6. Modgill V, Garg T, Goyal AK, Rath G. Permeability study of ciprofloxacin from ultra-thin nanofibrous film through various mucosal membranes. Artif Cells Nanomed Biotechnol 2014;1-6.
7. Marwah H, Garg T, Goyal AK, Rath G. Permeation enhancer strategies in transdermal drug delivery. Drug Deliv 2014;1-15.
8. Singh B, Garg T, Goyal AK, Rath G. Recent advancements in the cardiovascular drug carriers. Artif Cells Nanomed Biotechnol 2014a;1-10.
9. Kaur R, Garg T, Das Gupta U, et al. Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs. Artif Cells Nanomed Biotechnol 2014d;1-6.
10. Kaur R, Garg T, Malik B, et al. Development and characterization of spray-dried porous nanoaggregates for pulmonary delivery of anti-tubercular drugs. Drug Deliv 2014e;1-6.
11. Kaur M, Garg T, Rath G, Goyal AK. Current nanotechnological strategies for effective delivery of bioactive drug molecules in the treatment of tuberculosis. Crit Rev Ther Drug Carrier Syst 2014a; 31:49-88.
12. Kaur M, Malik B, Garg T, et al. Development and characterization of guar gum nanoparticles for oral immunization against tuberculosis. Drug Deliv 2014b.
13. Kaur P, Garg T, Rath G, et al. Surfactant-based drug delivery systems for treating drug-resistant lung cancer. Drug Deliv 2014c; 1-12.
14. Barber J. Examining the use of tramadol hydrochloride as an antidepressant. Exp Clin Psychopharmacol 2011;19:123-30.
15. Kilts CD. Potential new drug delivery systems for antidepressants: an overview. J Clin Psychiatry 2003;64:31-3.
16. Misra A, Ganesh S, Shahiwala A, Shah SP. Drug delivery to the central nervous system: a review. J Pharm Pharm Sci 2003;6: 252-73.
17. Alam MI, Beg S, Samad A, et al. Strategy for effective brain drug delivery. Eur J Pharm Sci 2010;40:385-403.
18. Thorne RG, Pronk GJ, Padmanabhan V, Frey II WH. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004;127:481-96.
19. Johal HS, Garg T, Rath G, Goyal AK. Advanced topical drug delivery system for the management of vaginal candidiasis. Drug Deliv 2014;1-14.
20. Joshi D, Garg T, Goyal AK, Rath G. Advanced drug delivery approaches against periodontitis. Drug Deliv 2014;1-15.
21. Goyal G, Garg T, Malik B, et al. Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug Deliv 2013.
22. Goyal G, Garg T, Rath G, Goyal AK. Current nanotechnological strategies for an effective delivery of drugs in treatment of periodontal disease. Crit Rev Ther Drug Carrier Syst 2014;31: 89-119.
23. Garg T, Goyal AK. Biomaterial-based scaffolds-current status and future directions. Expert Opin Drug Deliv 2014;11:767-89.
24. Merkus FW, Verhoef JC, Schipper NG, Marttin E. Nasal mucociliary clearance as a factor in nasal drug delivery. Adv Drug Deliv Rev 1998;29:13-38.
25. Critchley H, Davis SS, Farraj NF, Illum L. Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system. J Pharm Pharmacol 1994;46:651-6.
26. Garg T, Singh O, Arora S, Murthy R. Scaffold: a novel carrier for cell and drug delivery. Crit Rev Ther Drug Carrier Syst 2012;29: 1-63.
27. Garg T, Singh S, Goyal AK. Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery. Crit Rev Ther Drug Carrier Syst 2013;30:369-409.
28. Gagandeep G, Garg T, Malik B, et al. Development and characterization of nano-fiber patch for the treatment of glaucoma. Eur J Pharm Sci 2014;53:10-16.
29. Garg T, Rath G, Goyal AK. Ancient and advanced approaches for the treatment of an inflammatory autoimmune disease-psoriasis. Crit Rev Ther Drug Carrier Syst 2014;31:331-64.
30. Gupta S, Samanta MK, Raichur AM. Dual-drug delivery system based on in situ gel-forming nanosuspension of forskolin to enhance antiglaucoma efficacy. AAPS PharmSciTech 2010;11: 322-35.
31. Chaudhary S, Garg T, Murthy RS, et al. Recent approaches of lipid-based delivery system for lymphatic targeting via oral route. J Drug Target 2014;22:871-82.
32. Gupta H, Aqil M, Khar RK, et al. Nanoparticles laden in situ gel of levofloxacin for enhanced ocular retention. Drug Deliv 2013;20: 306-9.
33. Katas H, Alpar HO. Development and characterisation of chitosan nanoparticles for siRNA delivery. J Control Release 2006;115: 216-25.
34. Ibrahim el-SA, Ismail S, Fetih G, et al. Development and characterization of thermosensitive pluronic-based metronidazole in situ gelling formulations for vaginal application. Acta Pharm 2012; 62: 59-70.
35. Geng H, Song H, Qi J, Cui D. Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix. Nanoscale Res Lett 2011;6:312-320.
36. Singh H, Sharma R, Joshi M, et al. Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofibers. Artif Cells Nanomed Biotechnol 2014b.
37. Venkatesan P, Puvvada N, Dash R, et al. The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer. Biomaterials 2011;32:3794-806.
38. Sharma S, Lohan S, Murthy RS. Formulation and characterization of intranasal mucoadhesive nanoparticulates and thermo-reversible gel of levodopa for brain delivery. Drug Dev Ind Pharm 2014c;40: 869-78.
39. Chenu F, Guiard BP, Bourin M, Gardier AM. Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test. Behav Brain Res 2006;172:256-63.
40. Barefoot JC, Heitmann BL, Helms MJ, et al. Symptoms of depression and changes in body weight from adolescence to mid-life. Int J Obes Relat Metab Disord 1998;22:688-94.
41. Brenes Saenz JC, Villagra OR, Fornaguera Trias J. Factor analysis of forced swimming test, sucrose preference test and open field test on enriched, social and isolated reared rats. Behav Brain Res 2006; 169:57-65.
42. Wills ED. Mechanisms of lipid peroxide formation in tissues. Role of metals and haematin proteins in the catalysis of the oxidation unsaturated fatty acids. Biochim Biophys Acta 1965;98:238-51.
43. Wills ED. Mechanisms of lipid peroxide formation in animal tissues. Biochem J 1966;99:667-76.
44. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70-7.
45. Green LC, Wagner DA, Glogowski J, et al. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982; 126:131-8.