In vivo evaluation of thiolated chitosan tablets for oral insulin delivery

Journal of Pharmaceutical Sciences

Volumn 103, Issue 10, 2014, Pages 3165-3170

  Millotti, Gioconda ^a   Laffleur, Flavia ^a   Perera, Glen ^a   Vigl, Claudia ^a   Pickl, Karin ^b   Sinner, Frank ^b   Bernkop SCHNÜ Rch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Bioavailability; Chitosan; Drug release; In vivo in vitro corrlations (ivic); Mucoadhesion; Oral delivery of insulin in vivo studies; Oral drug delivery; Polymeric drug delivery systems; Solid dosage forms; Thiolated chitosan

Indexed keywords

CHITOSAN; CHITOSAN 6 MERCAPTONICOTINIC ACID; HUMAN INSULIN; INSULIN; POLYMER; THIOL GROUP; UNCLASSIFIED DRUG; TABLET; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS REACTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MUCOADHESION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; SUSTAINED DRUG RELEASE; TABLET; ANIMAL; CHEMISTRY; MALE; ORAL DRUG ADMINISTRATION; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; CHITOSAN; INSULIN; MALE; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; TABLETS;

EID: 84923362331     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24102     Document Type: Article

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