Mutational studies to understand the structure-function relationship in multidrug efflux transporters: Applications for distinguishing mutants with high specificity

International Journal of Biological Macromolecules

Volumn 75, Issue , 2015, Pages 218-224

  Gromiha, M Michael ^a   Anoosha, P ^a   Velmurugan, D ^b   Fukui, Kazuhiko ^c  

^a INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

^b UNIVERSITY OF MADRAS   (India)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Amino acid properties; Membrane protein; Multidrug efflux transporter; Multiple regression technique

Indexed keywords

AMINO ACID; MULTIDRUG RESISTANCE PROTEIN; ANTIPORTER; CARRIER PROTEIN; MUTANT PROTEIN; VINCRISTINE;

ACCURACY; AMINO ACID SUBSTITUTION; ARTICLE; EC50; IC50; MINIMUM INHIBITORY CONCENTRATION; MUTATION; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MULTIDRUG RESISTANCE;

AMINO ACIDS; ANTIPORTERS; DRUG RESISTANCE, MULTIPLE; INHIBITORY CONCENTRATION 50; KINETICS; MEMBRANE TRANSPORT PROTEINS; MUTANT PROTEINS; MUTATION; P-GLYCOPROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; VINCRISTINE;

EID: 84923361015     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2015.01.028     Document Type: Article

References (34)

1. Gromiha M.M., Yabuki Y., Suresh M.X., Thangakani A.M., Suwa M., Fukui K. Nucl. Acids Res. 2009, 37:D201-D204.
2. Yang R.Y., Scavetta R., Chang X.B. Biochemistry 2008, 47:8456-8464.
3. Zhang D.W., Cole S.P., Deeley R.G. J. Biol. Chem. 2002, 277:20934-20941.
4. Yang Y.Y., Chen Q., Zhang J.T. J. Biol. Chem. 2002, 277:44268-44277.
5. Storm J., O'Mara M.L., Crowley E.H., Peall J., Tieleman D.P., Kerr I.D., Callaghan R. Biochemistry 2007, 46:9899-9910.
6. Storm J., Modok S., O'Mara M.L., Tieleman D.P., Kerr I.D., Callaghan R. Biochemistry 2008, 47:3615-3624.
7. Otsuka M., Yasuda M., Morita Y., Otsuka C., Tsuchiya T., Omote H., Moriyama Y. J. Bacteriol. 2005, 187:1552-1558.
8. Adler J., Bibi E. J. Biol. Chem. 2004, 279:8957-8965.
9. Zhang D.W., Gu H.M., Situ D., Haimeur A., Cole S.P.C., Deeley R.G. J. Biol. Chem. 2003, 278:46052-46063.
10. Koike K., Conseil G.L., Leslie E.M., Deeley R.G., Cole S.P.C. J. Biol. Chem. 2004, 279:12325-12336.
11. Sharom F.J. Essays Biochem. ABC Transp. 2011, 50:161-178.
12. Bhardwaj A.K., Mohanty P. Recent Pat. Antiinfect. Drug Discov. 2012, 7:73-89.
13. Murakami S., Nakashima R., Yamashita E., Matsumoto T., Yamaguchi A. Nature 2006, 443:173-179.
14. Baker J., Wright S.H., Tama F. Proteins Struct. Funct. Bioinform. 2012, 80:1620-1632.
15. Ma J., Biggin P.C. Proteins 2013, 81:1653-1668.
16. Liu M., Hou T., Feng Z., Li Y. J. Biomol. Struct. Dyn. 2013, 31:612-629.
17. Ward A.B., Szewczyk P., Grimard V., Lee C.W., Martinez L., Doshi R., Caya A., Villaluz M., Pardon E., Cregger C., Swartz D.J., Falson P.G., Urbatsch I.L., Govaerts C., Steyaert J., Chang G. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:13386-13391.
18. Martinez L., Arnaud O., Henin E., Tao H., Chaptal V., Doshi R., Andrieu T., Dussurgey S., Tod M., Di Pietro A., Zhang Q., Chang G., Falson P. FEBS J. 2014, 281:673-682.
19. Gromiha M.M., Yabuki Y. BMC Bioinform. 2008, 9:135.
20. Li H.Q., Dai X.B., Zhao X.C. Bioinformatics 2008, 24:1129-1136.
21. Li H.Q., Benedito V.A., Udvardi M.K., Zhao P.X. BMC Bioinform. 2009, 10:418.
22. Ou Y.Y., Chen S.A., Gromiha M.M. Proteins Struct. Funct. Bioinform. 2010, 78:1789-1797.
23. Ou Y.Y., Chen S.A., Chang Y.M., Velmurugan D., Fukui K., Gromiha M.M. Proteins Struct. Funct. Bioinform. 2013, 81:1634-1643.
24. Dolghih E., Bryant C., Renslo A.R., Jacobson M.P. PLoS Comput. Biol. 2011, 7:e1002083.
25. Bikadi Z., Hazai I., Malik D., Jemnitz K., Veres Z., Hari P., Ni Z.L., Loo T.W., Clarke D.M., Hazai E., Mao Q.C. PLoS ONE 2011, 6:e25815.
26. Chen S.A., Ou Y.Y., Lee T.Y., Gromiha M.M. Bioinformatics 2011, 27:2062-2067.
27. Gromiha M.M., Ou Y.Y. Brief Bioinform. 2014, 15:155-168.
28. Gromiha M.M., Harini K., Sowdhamini R., Fukui K. BMC Bioinform. 2012, 13(Suppl. 7):S1.
29. Gromiha M.M. J. Chem. Inf. Model. 2005, 45:494-501.
30. Gromiha M.M., Oobatake M., Kono H., Uedaira H., Sarai A. Protein Eng. 1999, 12:549-555.
31. Grewal P.S. Numerical Methods of Statistical Analysis 1987, Sterling Publishers, New Delhi.
32. Witten I.H., Frank E. Data Mining: Practical Machine Learning Tools and Techniques 2005, Morgan Kaufmann, San Francisco. 2nd ed.
33. Gromiha M.M., Suwa M. Proteins 2006, 63:1031-1037.
34. Gromiha M.M. Protein Bioinformatics: From Sequence to Function 2010, Elseiver/Academic Press, New Delhi.