Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma

Oncotarget

Volumn 6, Issue 5, 2015, Pages 3359-3374

  Diaz, Roberto Jose ^a,b   Golbourn, Brian ^a   Faria, Claudia ^a   Picard, Daniel ^a   Shih, David ^a   Raynaud, Denis ^a   Leadly, Michael ^a   MacKenzie, Danielle ^a   Bryant, Melissa ^a   Bebenek, Matthew ^a   Smith, Christian A ^a   Taylor, Michael D ^a,b   Huang, Annie ^a   Rutka, James T ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Aurora kinase; Cell cycle; Medulloblastoma; Molecular therapy; Tumor biology

Indexed keywords

AURORA B KINASE; BARASERTIB; MESSENGER RNA; ANTINEOPLASTIC AGENT; AURKB PROTEIN, HUMAN; AZD 1152-HQPA; MYC PROTEIN; MYC PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DNA REPLICATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG SENSITIVITY; EMBRYO; ENDOREDUPLICATION; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MEDULLOBLASTOMA; MEDULLOBLASTOMA CELL LINE; MOUSE; NONHUMAN; ONCOGENE MYC; PROTEIN EXPRESSION; SURVIVAL TIME; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CEREBELLAR NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR CELL LINE; TUMOR VOLUME; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AURORA KINASE B; CELL LINE, TUMOR; CELL PROLIFERATION; CEREBELLAR NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEDULLOBLASTOMA; MICE, NUDE; MOLECULAR TARGETED THERAPY; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MYC; QUINAZOLINES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84923315705     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3245     Document Type: Article

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