The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction

Nature Communications

Volumn 5, Issue , 2014, Pages

  Park, L ^a   Wang, G ^a   Moore, J ^a   Girouard, H ^a   Zhou, P ^a   Anrather, J ^a   Iadecola, C ^a  

^a FEIL FAMILY BRAIN AND MIND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; AMYLOID BETA PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; CALCIUM; ENZYME INHIBITOR; GLYCOSIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PEROXYNITROUS ACID; POLY ADP-RIBOSE GLYCOHYDROLASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, RAT;

BRAIN; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE; NERVOUS SYSTEM DISORDER; NEUROLOGY; PATHOLOGY; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DYSFUNCTION; CALCIUM CELL LEVEL; CONTROLLED STUDY; DNA DAMAGE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; IN VIVO STUDY; MALE; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; ADRENERGIC SYSTEM; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; BRAIN CIRCULATION; CHANNEL GATING; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; MICROVASCULATURE; NERVOUS SYSTEM; NITROSATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; TRANSGENIC MOUSE; VASCULARIZATION;

AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; CALCIUM; CEREBROVASCULAR CIRCULATION; DNA DAMAGE; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; ION CHANNEL GATING; MICE, TRANSGENIC; MICROVESSELS; NERVOUS SYSTEM; NITROSATION; PEROXYNITROUS ACID; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; POLY(ADP-RIBOSE) POLYMERASES; STRESS, PHYSIOLOGICAL; TRPM CATION CHANNELS; VASOMOTOR SYSTEM;

EID: 84923301658     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6318     Document Type: Article

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