DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: A population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort

Neuropathology and Applied Neurobiology

Volumn 40, Issue 7, 2014, Pages 802-814

  Garwood, Claire J ^a   Simpson, Julie E ^a   Al Mashhadi, Sufana ^a,d   Axe, Claire ^a   Wilson, Suzanna ^a   Heath, Pamela R ^a   Shaw, Pamela J ^a   Matthews, Fiona E ^b   Brayne, Carol ^c   Ince, Paul G ^a   Wharton, Stephen B ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b MRC BIOSTATISTICS UNIT   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d KING FAHAD MEDICAL CITY   (Saudi Arabia)

Author keywords

Ageing; Alzheimer's disease; DNA damage; Endothelial cells; Senes cence

Indexed keywords

AGED; ALZHEIMER DISEASE; BRAIN CORTEX; CELL AGING; DISEASE COURSE; DNA DAMAGE; ENDOTHELIUM CELL; FRONTAL LOBE; GENETICS; HUMAN; METABOLISM; MICROVASCULATURE; TEMPORAL LOBE; VASCULARIZATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CELL AGING; CEREBRAL CORTEX; DISEASE PROGRESSION; DNA DAMAGE; ENDOTHELIAL CELLS; FRONTAL LOBE; HUMANS; MICROVESSELS; TEMPORAL LOBE;

EID: 84911062720     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/nan.12156     Document Type: Article

References (33)

1. Zlokovic B. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008; 57: 178-201
2. Brown W, Thore C. Cerebral microvascular pathology in ageing and neurodegeneration. Neuropathol Appl Neurobiol 2011; 37: 56-74
3. Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 2011; 12: 723-738. PubMed PMID: 22048062, Epub 4 November 2011
4. Farrall A, Wardlaw J. Blood-brain barrier: ageing and microvascular disease - systematic review and meta-analysis. Neurobiol Aging 2009; 30: 337-352
5. Viggars A, Wharton S, Simpson J, Matthews F, Brayne C, Savva G, Garwood C, Drew D, Shaw PJ, Ince PG. Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort. Neurosci Lett 2011; 505: 25-30
6. Simpson J, Ince P, Lace G, Forster G, Shaw P, Matthews F, Savva G, Brayne C, Wharton SB, on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group. Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain. Neurobiol Aging 2010; 31: 578-590
7. Simpson J, Ince P, Shaw P, Heath P, Raman R, Garwood C, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB, on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group. Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and APOE genotype. Neurobiol Aging 2011; 32: 1795-1807
8. Merlini M, Meyer E, Ulmann-Schuler A, Nitsch R. Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAb mice. Acta Neuropathol 2011; 122: 293-311
9. Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG. Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience. J Alzheimers Dis 2011; 25: 359-372. PubMed PMID: 21422529, Epub 23 March 2011
10. Stephan BCM, Wharton SB, Simpson J, Matthews FE, Ince P, Brayne C. The epidemiological neuropathology of dementia and the implications for drug development. Neurodegener Dis Manag 2012; 2: 471-482
11. Cognitive function and dementia in six areas of England and Wales: the distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Psychol Med 1998; 28: 319-335. PubMed PMID: 9572090, Epub 8 May 1998
12. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 2001; 357: 169-175. PubMed PMID: 11213093, Epub 24 February 2001
13. Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C. Age, neuropathology, and dementia. N Engl J Med 2009; 360: 2302-2309. PubMed PMID: 19474427, Epub 29 May 2009
14. Simpson J, Ince P, Haynes L, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE, Savva GM, Brayne C, Wharton SB, on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group. Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol 2010; 36: 25-40
15. Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 2009; 118: 103-113. Pubmed Central PMCID: PMC2853006, PubMed PMID: 19319544, Epub 26 March 2009
16. Breteler MM. Vascular involvement in cognitive decline and dementia. Epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study. Ann N Y Acad Sci 2000; 903: 457-465. PubMed PMID: 10818538, Epub 20 May 2000
17. de la Torre JC. Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol 2004; 3: 184-190. PubMed PMID: 14980533, Epub 26 February 2004
18. de la Torre JC, Mussivand T. Can disturbed brain microcirculation cause Alzheimer's disease? Neurol Res 1993; 15: 146-153. PubMed PMID: 8103579, Epub 1 June 1993
19. Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE, Savva GM, Brayne C, Wharton SB. Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol 2010; 36: 25-40. PubMed PMID: 19422529, Epub 9 May 2009
20. Faraco G, Iadecola C. Hypertension: a harbinger of stroke and dementia. Hypertension 2013; 62: 810-817. PubMed PMID: 23980072, Epub 28 August 2013
21. Smith GC, Jackson SP. The DNA-dependent protein kinase. Genes Dev 1999; 13: 916-934. PubMed PMID: 10215620, Epub 24 April 1999
22. Love S, Barber R, Wilcock GK. Neuronal death in brain infarcts in man. Neuropathol Appl Neurobiol 2000; 26: 55-66. PubMed PMID: 10736067, Epub 29 March 2000
23. Li B, Shang ZF, Yin JJ, Xu QZ, Liu XD, Wang Y, Zhang SM, Guan H, Zhou PK. PIG3 functions in DNA damage response through regulating DNA-PKcs homeostasis. Int J Biol Sci 2013; 9: 425-434. Pubmed Central PMCID: PMC3654439, PubMed PMID: 23678292, Epub 17 May 2013
24. Hemnani T, Parihar MS. Reactive oxygen species and oxidative DNA damage. Indian J Physiol Pharmacol 1998; 42: 440-452. PubMed PMID: 10874342, Epub 30 June 2000
25. Rizzo M, Leaver H. Brain endothelial cell death: modes, signaling pathways, and relevance to neural development, homeostasis, and disease. Mol Neurobiol 2010; 42: 52-63
26. Wolburg H, Noell S, Wolburg-Buchholz K, Mack A, Fallier-Becker P. Agrin, aquaporin-4, and astrocyte polarity as an important feature of the blood-brain barrier. Neuroscientist 2009; 15: 180-193. PubMed PMID: 19307424, Epub 25 March 2009
27. Chong ZZ, Li F, Maiese K. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol 2005; 75: 207-246. PubMed PMID: 15882775, Epub 11 May 2005
28. Coomber BL, Stewart PA. Morphometric analysis of CNS microvascular endothelium. Microvasc Res 1985; 30: 99-115. PubMed PMID: 4021842, Epub 1 July 1985
29. Jurk D, Wang C, Miwa S, Maddick M, Korolchuk V, Tsolou A, Gonos ES, Thrasivoulou C, Saffrey MJ, Cameron K, von Zglinicki T. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 2012; 11: 996-1004. Pubmed Central PMCID: PMC3533793, PubMed PMID: 22882466, Epub 14 August 2012
30. Bhat R, Crowe EP, Bitto A, Moh M, Katsetos CD, Garcia FU, Johnson FB, Trojanowski JQ, Sell C, Torres C. Astrocyte senescence as a component of Alzheimer's disease. PLoS ONE 2012; 7: e45069. Pubmed Central PMCID: PMC3440417, PubMed PMID: 22984612, Epub 18 September 2012
31. Freund A, Orjalo AV, Desprez PY, Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010; 16: 238-246. Pubmed Central PMCID: PMC2879478, PubMed PMID: 20444648, Epub 7 May 2010
32. Kalaria RN. The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease. Ann N Y Acad Sci 1999; 893: 113-125. PubMed PMID: 10672233, Epub 15 February 2000
33. Hawkes CA, Gatherer M, Sharp MM, Dorr A, Yuen HM, Kalaria R, Weller RO, Carare RO. Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-beta from the mouse brain. Aging Cell 2013; 12: 224-236. PubMed PMID: 23413811, Epub 19 February 2013