Sustained release of PTX-incorporated nanoparticles synergized by burst release of DOX·HCl from thermosensitive modified PEG/PCL hydrogel to improve anti-tumor efficiency

European Journal of Pharmaceutical Sciences

Volumn 62, Issue , 2014, Pages 267-273

  Xu, Shuxin ^a   Wang, Weiwei ^b   Li, Xijing ^c   Liu, Jianping ^a   Dong, Anjie ^a,d,e   Deng, Liandong ^a  

^a TIANJIN UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c Tianjin Institute of Medical and Pharmaceutical Science   (China)

^d BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^e Collaborative Innovation Center of Chemical Science and Engineering   (China)

Author keywords

Anti tumor; Dual drugs; Hydrogel; Nanoparticle; Synergy; Thermo sensitive

Indexed keywords

COPOLYMER; DOXORUBICIN; MACROGOL; NANOPARTICLE; PACLITAXEL; POLY(EPSILON CAPROLACTONE CO 1,4,8 TRIOXA[4.6]SPIRO 9 UNDECANONE)POLY(ETHYLENE GLYCOL)POLY(EPSILON CAPROLACTONE CO 1,4,8 TRIOXA[4.6]SPIRO 9 UNDECANONE); POLYCAPROLACTONE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER; HYDROGEL; MACROGOL DERIVATIVE; POLYESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; HEAT SENSITIVITY; HYDROGEL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; TEMPERATURE SENSITIVE MUTANT; ADMINISTRATION AND DOSAGE; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, EHRLICH TUMOR; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; DRUG RELEASE; PATHOLOGY; TEMPERATURE; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, EHRLICH TUMOR; CELL LINE, TUMOR; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; DRUG CARRIERS; DRUG LIBERATION; HYDROGELS; MICE, INBRED BALB C; NANOPARTICLES; PACLITAXEL; POLYESTERS; POLYETHYLENE GLYCOLS; TEMPERATURE; TUMOR BURDEN;

EID: 84903735371     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.06.002     Document Type: Article

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