A convergent synthetic platform for single-nanoparticle combination cancer therapy: Ratiometric loading and controlled release of cisplatin, doxorubicin, and camptothecin

Journal of the American Chemical Society

Volumn 136, Issue 16, 2014, Pages 5896-5899

  Liao, Longyan ^a   Liu, Jenny ^a   Dreaden, Erik C ^b   Morton, Stephen W ^b   Shopsowitz, Kevin E ^b   Hammond, Paula T ^b   Johnson, Jeremiah A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; DRUG DELIVERY; FUNCTIONAL POLYMERS; PLATINUM COMPOUNDS;

CAMPTOTHECIN (CPT); COMBINATION THERAPY; CONTROLLED RELEASE; POLYMER NANOPARTICLES; POLYMER THERAPEUTICS; SYNTHETIC APPROACH; SYNTHETIC POLYMERS; THERAPEUTIC AGENTS;

LOADING;

CAMPTOTHECIN; CISPLATIN; DOXORUBICIN; MONOMER; NANOPARTICLE; ANTINEOPLASTIC AGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER;

ARTICLE; CANCER CELL LINE; CANCER COMBINATION CHEMOTHERAPY; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOTOXICITY; FLUORESCENCE MICROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTERNALIZATION; MASS SPECTROMETRY; NANOFABRICATION; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET SPECTROSCOPY; CELL SURVIVAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; DRUG CARRIERS; HUMANS; NANOPARTICLES;

EID: 84899506759     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja502011g     Document Type: Article

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