A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness

Nature Communications

Volumn 5, Issue , 2014, Pages

  Russell, Theron A ^a   Blizinsky, Katherine D ^a   Cobia, Derin J ^a   Cahill, Michael E ^a   Xie, Zhong ^a   Sweet, Robert A ^b   Duan, Jubao ^c,d   Gejman, Pablo V ^c,d   Wang, Lei ^a   Csernansky, John G ^a   Penzes, Peter ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAC1 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; KALRN PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; RAC1 PROTEIN, HUMAN;

AMINO ACID; GENE EXPRESSION; HUMAN GEOGRAPHY; NEUROLOGY; POLYMORPHISM; PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CATALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICAL THICKNESS (BRAIN); DENDRITIC SPINE; ENZYME ACTIVE SITE; EXON; FEMALE; GENE; HUMAN; HUMAN CELL; KALRN GENE; MAJOR DEPRESSION; MALE; MOUSE; NEUROPIL; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCHIZOPHRENIA; SUPERIOR TEMPORAL SULCUS; AMINO ACID SUBSTITUTION; ANIMAL; ANIMAL EMBRYO; CASE CONTROL STUDY; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PRIMARY CELL CULTURE; RAT; SIBLING; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE;

MUS; RODENTIA;

ADULT; AMINO ACID SUBSTITUTION; ANIMALS; CASE-CONTROL STUDIES; CEREBRAL CORTEX; DEPRESSIVE DISORDER, MAJOR; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION REGULATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, TRANSGENIC; NEURONS; NEUROPIL; PRIMARY CELL CULTURE; PROTEIN-SERINE-THREONINE KINASES; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; SCHIZOPHRENIA; SEQUENCE ANALYSIS, DNA; SIBLINGS; SIGNAL TRANSDUCTION;

EID: 84923250088     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5858     Document Type: Article

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