Interpreting the significance of decreased cortical serotonin 2A receptors in schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 33, Issue 8, 2009, Pages 1583-1584

  Dean, Brian ^a  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; MUSCARINIC M1 RECEPTOR; SEROTONIN 2A RECEPTOR;

AUTOPSY; COHORT ANALYSIS; CORRELATION COEFFICIENT; HIGH RISK PATIENT; HUMAN; LETTER; NEUROIMAGING; NEUROPATHOLOGY; PREFRONTAL CORTEX; SCHIZOPHRENIA; TISSUE HOMOGENATE;

CEREBRAL CORTEX; DOWN-REGULATION; HUMANS; RECEPTOR, SEROTONIN, 5-HT2A; SCHIZOPHRENIA;

EID: 71549137122     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2009.08.006     Document Type: Letter

References (12)

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2. Dean B., Crossland N., Boer S., and Scarr E. Evidence for altered post-receptor modulation of the serotonin 2a receptor in schizophrenia. Schizophr Res 104 (2008) 185-197
3. Dean B., and Hayes W. Decreased frontal cortical serotonin2A receptors in schizophrenia. Schizophr Res 21 (1996) 133-139
4. Dean B., Hayes W., Opeskin K., Naylor L., Pavey G., Hill C., Keks N., and Copolov D.L. Serotonin2 receptors and the serotonin transporter in the schizophrenic brain. Behav Brain Res 73 (1996) 169-175
5. Dean B., Hussain T., Hayes W., Scarr E., Kitsoulis S., Hill C., Opeskin K., and Copolov D.L. Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex. J Neurochem 72 (1999) 1593-1599
6. Gliner J.A., Morgan G.A., and Harmon R.J. Basic associational designs: analysis and interpretation. J Am Acad Child Adolesc Psychiatry 41 (2002) 1256-1258
7. Hurlemann R., Boy C., Meyer P.T., Scherk H., Wagner M., Herzog H., Coenen H.H., Vogeley K., Falkai P., Zilles K., Maier W., and Bauer A. Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia. Anat Embryol (Berl) 210 (2005) 519-523
8. Hurlemann R., Matusch A., Kuhn K.U., Berning J., Elmenhorst D., Winz O., Kolsch H., Zilles K., Wagner M., Maier W., and Bauer A. 5-HT2A receptor density is decreased in the at-risk mental state. Psychopharmacology (Berl.) 195 (2008) 579-590
9. Kang K., Huang X.F., Wang Q., and Deng C. Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia-a postmortem study. Prog Neuropsychopharmacol Biol Psychiatry (2009)
10. Narayan S., Head S.R., Gilmartin T.J., Dean B., and Thomas E.A. Evidence for disruption of sphingolipid metabolism in schizophrenia. J Neurosci Res 87 (2009) 278-288
11. Pralong D., Tomaskovic-Crook E., Opeskin K., Copolov D., and Dean B. Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia. Schizophr Res 44 (2000) 35-45
12. Tang B., Chang W.L., Lanigan C.M., Dean B., Sutcliffe J.G., and Thomas E.A. Normal human aging and early-stage schizophrenia share common molecular profiles. Aging Cell 8 (2009) 339-342