The function of phosphatidylinositol 5-phosphate 4-kinase γ (Pi5p4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

Biochemical Journal

Volumn 466, Issue , 2015, Pages 359-367

  Clarke, Jonathan H ^a   Giudici, Maria Luisa ^a   Burke, John E ^b,d   Williams, Roger L ^b   Maloney, David J ^c   Marugan, Juan ^c   Irvine, Robin F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF VICTORIA   (Canada)

Author keywords

Phosphatidylinositol 5 phosphate (pi5p); Phosphatidylinositol 5 phosphate 4 kinase (pi5p4k); Phosphatidylinositol 5 phosphate 4 kinase (pi5p4k )

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AMINO ACID; PHOSPHATIDYLINOSITOL 5 PHOSPHATE 4 KINASE GAMMA; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; ISOENZYME; MUTANT PROTEIN; NIH-12848; PHOSPHATIDYLINOSITOL 5-PHOSPHATE; PIP4K2C PROTEIN, MOUSE; POLYPHOSPHOINOSITIDE; QUINAZOLINE DERIVATIVE; RECOMBINANT PROTEIN; THIOPHENE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL CULTURE; CELL FUNCTION; CELL GROWTH; CELL MEMBRANE; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVITY; ENZYME ISOLATION; IN VITRO STUDY; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; CELL LINE; CELL POLARITY; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; KIDNEY CORTEX; METABOLISM; PROTEIN CONFORMATION; PROTEIN TRANSPORT; RNA INTERFERENCE;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELL DIFFERENTIATION; CELL LINE; CELL MEMBRANE; CELL POLARITY; DEUTERIUM EXCHANGE MEASUREMENT; ENZYME INHIBITORS; ISOENZYMES; KIDNEY CORTEX; MICE; MODELS, MOLECULAR; MUTANT PROTEINS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN CONFORMATION; PROTEIN TRANSPORT; QUINAZOLINES; RECOMBINANT PROTEINS; RNA INTERFERENCE; THIOPHENES;

EID: 84923233768     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20141333     Document Type: Article

References (31)

1. Clarke, J.H., Wang, M. and Irvine, R.F. (2010) Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases. Adv. Enzyme Regul. 50, 12-18 CrossRef PubMed
2. Clarke, J.H. and Irvine, R.F. (2012) The activity, evolution and association of phosphatidylinositol 5-phosphate 4-kinases. Adv. Biol. Regul. 52, 40-45 CrossRef PubMed
3. Shah, Z.H., Jones, D.R., Sommer, L., Foulger, R., Bultsma, Y., D'Santos, C. and Divecha, N. (2013) Nuclear phosphoinositides and their impact on nuclear functions. FEBS J. 280, 6295-6310 CrossRef PubMed
4. Gelato, K.A., Tauber, M., Ong, M.S., Winter, S., Hiragami-Hamada, K., Sindlinger, J., Lemak, A., Bultsma, Y., Houliston, S., Schwarzer, D. et al. (2014) Accessibility of different histone H3-binding domains of UHRF1 Is allosterically regulated by phosphatidylinositol 5-phosphate. Mol. Cell 54, 905-919 CrossRef PubMed
5. Keune, W.J., Jones, D.R. and Divecha, N. (2013) PtdIns5P and Pin1 in oxidative stress signaling. Adv. Enzyme Regul. 53, 179-189 CrossRef
6. Lamia, K.A., Peroni, O.D., Kim, Y.B., Rameh, L.E., Kahn, B.B. and Cantley, L.C. (2004) Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol. Cell. Biol. 24, 5080-5087 CrossRef PubMed
7. Emerling, B.M., Hurov, J.B., Poulogiannis, G., Tsukazawa, K.S., Choo-Wing, R., Wulf, G.M., Bell, E.L., Shim, H.S., Lamia, K.A., Rameh, L.E. et al. (2013) Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell 155, 844-857 CrossRef PubMed
8. Jude, J.G., Spencer, G.J., Huang, X., Somerville, T.D., Jones, D.R., Divecha, N. and Somervaille, T.C. (2014) A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival. Oncogene, doi: 10.1038/onc.2014.77
9. Clarke, J.H., Emson, P.C. and Irvine, R.F. (2008) Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron. Am. J. Physiol. Renal Physiol. 295, F1422-F1430 CrossRef PubMed
10. Clarke, J.H., Emson, P.C. and Irvine, R.F. (2009) Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIγ in the mouse brain. J. Comp. Neurol. 517, 296-312 CrossRef PubMed
11. Yih, L.H., Wu, Y.C., Hsu, N.C. and Kuo, H.H. (2012) Arsenic trioxide induces abnormal mitotic spindles through a PIP4KIIgamma/Rho pathway. Toxicol. Sci. 128, 115-125 CrossRef PubMed
12. Clarke, J.H. and Irvine, R.F. (2013) Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization. Biochem. J. 454, 49-57 CrossRef PubMed
13. Wang, M., Bond, N.J., Letcher, A.J., Richardson, J.P., Lilley, K.S., Irvine, R.F. and Clarke, J.H. (2010) Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIα and IIβ and a partial nuclear localisation of the IIα isoform. Biochem. J. 430, 215-221 CrossRef PubMed
14. Bultsma, Y., Keune, W.J. and Divecha, N. (2010) PIP4Kβ interacts with and modulates nuclear localisation of the high activity PtdIns5P-4-kinase isoform, PIP4Kα. Biochem. J. 430, 223-235 CrossRef PubMed
15. Davis, M.I., Sasaki, A.T., Shen, M., Emerling, B.M., Thorne, N., Michael, S., Pragani, R., Boxer, M., Sumita, K., Takeuchi, K. et al. (2013) A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. PLoS One 8, e54127 CrossRef PubMed
16. Voss, M.D., Czechtizky, W., Li, Z., Rudolph, C., Petry, S., Brummerhop, H., Langer, T., Schiffer, A. and Schaefer, H.L. (2014) Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta. Biochem. Biophys. Res. Commun. 449, 327-331 CrossRef PubMed
17. Berndt, A., Miller, S., Williams, O., Le, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.C., Liu, Y., Rommel, C. et al. (2010) The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat. Chem. Biol. 6, 117-124 CrossRef PubMed
18. Adrian, F.J., Ding, Q., Sim, T., Velentza, A., Sloan, C., Liu, Y., Zhang, G., Hur, W., Ding, S., Manley, P. et al. (2006) Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat. Chem. Biol. 2, 95-102 CrossRef PubMed
19. Bligh, E.G. and Dyer, W.J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917 CrossRef PubMed
20. Vadas, O., Dbouk, H.A., Shymanets, A., Perisic, O., Burke, J.E., Abi Saab, W.F., Khalil, B.D., Harteneck, C., Bresnick, A.R., Nurnberg, B. et al. (2013) Molecular determinants of PI3Kgamma-mediated activation downstream of G-protein-coupled receptors (GPCRs). Proc. Natl. Acad. Sci. U.S.A. 110, 18862-18867 CrossRef PubMed
21. Burke, J.E., Perisic, O., Masson, G.R., Vadas, O. and Williams, R.L. (2012) Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110alpha (PIK3CA). Proc. Natl. Acad. Sci. U.S.A. 109, 15259-15264 CrossRef PubMed
22. Duong Van Huyen, J., Bens, M. and Vandewalle, A. (1998) Differential effects of aldosterone and vasopressin on chloride fluxes in transimmortalized mouse cortical collecting duct cells. J. Memb. Biol. 164, 79-90 CrossRef
23. Duong Van Huyen, J.P., Bens, M., Teulon, J. and Vandewalle, A. (2001) Vasopressin-stimulated chloride transport in transimmortalized mouse cell lines derived from the distal convoluted tubule and cortical and inner medullary collecting ducts. Nephrol. Dial. Transplant. 16, 238-245 CrossRef PubMed
24. Liang, Q., Dexheimer, T.S., Zhang, P., Rosenthal, A.S., Villamil, M.A., You, C., Zhang, Q., Chen, J., Ott, C.A., Sun, H. et al. (2014) A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat. Chem. Biol. 10, 298-304 CrossRef PubMed
25. Burke, J.E., Vadas, O., Berndt, A., Finegan, T., Perisic, O. and Williams, R.L. (2011) Dynamics of the phosphoinositide 3-kinase p110delta interaction with p85alpha and membranes reveals aspects of regulation distinct from p110alpha. Structure 19, 1127-1137 CrossRef PubMed
26. Kunz, J., Wilson, M.P., Kisseleva, M., Hurley, J.H., Majerus, P.W. and Anderson, R.A. (2000) The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol. Cell 5, 1-11 CrossRef PubMed
27. Kunz, J., Fuelling, A., Kolbe, L. and Anderson, R.A. (2002) Stereo-specific substrate recognition by phosphatidylinositol phosphate kinases is swapped by changing a single amino acid residue. J. Biol. Chem. 277, 5611-5619 CrossRef PubMed
28. Rao, V.D., Misra, S., Boronenkov, I.V., Anderson, R.A. and Hurley, J.H. (1998) Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell 94, 829-839 CrossRef PubMed
29. Gonin, S., Deschenes, G., Roger, F., Bens, M., Martin, P.Y., Carpentier, J.L., Vandewalle, A., Doucet, A. and Feraille, E. (2001) Cyclic AMP increases cell surface expression of functional Na, K-ATPase units in mammalian cortical collecting duct principal cells. Mol. Biol. Cell 12, 255-264 CrossRef PubMed
30. Maeda, A., Amano, M., Fukata, Y. and Kaibuchi, K. (2002) Translocation of Na(+),K(+)-ATPase is induced by Rho small GTPase in renal epithelial cells. Biochem. Biophys. Res. Commun. 297, 1231-1237 CrossRef PubMed
31. Ngok, S.P., Lin, W.H. and Anastasiadis, P.Z. (2014) Establishment of epithelial polarity-GEF who's minding the GAP? J. Cell Sci. 127, 3205-3215 CrossRef PubMed