Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization

Biochemical Journal

Volumn 454, Issue 1, 2013, Pages 49-57

  Clarke, Jonathan H ^a   Irvine, Robin F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Dimerization; Lipid kinase activity; Phosphatidylinositol 5 phosphate (ptdins5p); Phosphatidylinositol 5 phosphate 4 kinase (PI5P4K)

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DNA; PHOSPHATIDYLINOSITOL 5 PHOSPHATE 4 KINASE; PHOSPHATIDYLINOSITOL 5 PHOSPHATE 4 KINASE ALPHA; PHOSPHATIDYLINOSITOL 5 PHOSPHATE 4 KINASE BETA; PHOSPHATIDYLINOSITOL 5 PHOSPHATE 4 KINASE GAMMA; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; COMPUTER MODEL; DIMERIZATION; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME STRUCTURE; HUMAN; MAMMAL; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; EVOLUTION, MOLECULAR; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN MULTIMERIZATION;

EID: 84880913208     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130488     Document Type: Article

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