Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta

Biochemical and Biophysical Research Communications

Volumn 449, Issue 3, 2014, Pages 327-331

  Voss, Marc D ^a   Czechtizky, Werngard ^a   Li, Ziyu ^a   Rudolph, Christine ^a   Petry, Stefan ^a   Brummerhop, Harm ^a   Langer, Thomas ^a   Schiffer, Alexander ^a   Schaefer, Hans Ludwig ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Diabetes; Phosphatidylinositol 5 phosphate 4 kinase, type II, beta; PIP5K2B inhibitor; SAR088

Indexed keywords

ADIPONECTIN; CHOLESTEROL; ENZYME INHIBITOR; GLUCOSE; INSULIN; LEPTIN; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 5 PHOSPHATE 4 KINASE TYPE 2 BETA; PYRIMIDINE DERIVATIVE; SAR 088; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL ASSAY; CELL MEMBRANE PERMEABILITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYMATIC ASSAY; ENZYME INHIBITION; FLUORESCENCE POLARIZATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HIGH THROUGHPUT SCREENING; HYPERGLYCEMIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; MALE; METHYLATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION; TRIACYLGLYCEROL BLOOD LEVEL;

RATTUS;

DIABETES; PHOSPHATIDYLINOSITOL-5-PHOSPHATE 4-KINASE, TYPE II, BETA; PIP5K2B INHIBITOR; SAR088;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; IMIDAZOLIDINES; INSULIN RESISTANCE; MALE; MICE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PYRIMIDINES; RATS, ZUCKER; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902164849     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.05.024     Document Type: Article

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