Similarity between obesity and drug addiction as assessed by neurofunctional imaging: A concept review

Journal of Addictive Diseases

Volumn 23, Issue 3, 2004, Pages 39-53

  Wang, Gene Jack ^a   Volkow, Nora D ^a,b   Thanos, Panayotis K ^a   Fowler, Joanna S ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Dopamine receptor; Drug abuse; Obesity; Positron emission tomography; Somatosensory cortex

Indexed keywords

DOPAMINE 2 RECEPTOR; RACLOPRIDE C 11; TRACER; UNCLASSIFIED DRUG;

BEHAVIOR; BODY MASS; BRAIN TOMOGRAPHY; COMPULSION; DISEASE PREDISPOSITION; DRUG DEPENDENCE; FOOD INTAKE; HUMAN; IMAGE ANALYSIS; NONHUMAN; OBESITY; OVERNUTRITION; POSITRON EMISSION TOMOGRAPHY; REVIEW; REWARD; SOMATOSENSORY CORTEX; STRIATE CORTEX;

BRAIN; COCAINE; HUMANS; METHAMPHETAMINE; OBESITY; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, DOPAMINE D2; SUBSTANCE-RELATED DISORDERS;

EID: 3843146436     PISSN: 10550887     EISSN: None     Source Type: Journal    
DOI: 10.1300/J069v23n03_04     Document Type: Review

References (69)

1. Serdula MK, Mokdad AH, Williamson DF, et al. Prevalence of attempting weight loss and strategies for controlling weight. JAMA 1999; 282:1353-1358.
2. Hill JO, Peters JC. Environmental contributions to the obesity epidemic. Science 1998; 280:1371-1374.
3. Smith GP, Schneider LH. Relationships between mesolimbic dopamine function and eating behavior. Ann N Y Acad Sci 1988; 537:254-261.
4. Greeno CG, Wing RR. Stress-induced eating. Psychol Bull 1994; 115:444-464.
5. Bray GA, Tartaglia LA. Medicinal strategies in the treatment of obesity. Nature 2000; 404:672-677.
6. Schwartz MW, Woods SC, Porte D Jr, et al. Central nervous system control of food intake. Nature 2000; 404:661-671.
7. Blum K, Braverman ER, Holder JM, et al. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. J Psychoactive Drugs 2000;32 Suppl: 1-112.
8. Clifton PG, Rusk IN, Cooper SJ. Effects of dopamine D1 and dopamine D2 antagonists on the free feeding and drinking patterns of rats. Behav Neurosci 1991; 105:272-281.
9. Baptista T, Parada M, Hernandez L. Long term administration of some antipsychotic drugs increases body weight and feeding in rats. Are D2 dopamine receptors involved? Pharmacol Biochem Behav 1987;27:399-405.
10. Allison DB, Casey DE. Antipsychotic-induced weight gain: a review of the literature. J Clin Psychiatry 2001;62 Suppl 7:22-31.
11. Wetterling T. Bodyweight gain with atypical antipsychotics. A comparative review. Drug Saf 2001;24:59-73.
12. Scislowski PW, Tozzo E, Zhang Y, et al. Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists. Int J Obes Relat Metab Disord 1999;23:425-431.
13. Thanos PK, Volkow ND, Freimuth P, et al. Overexpression of dopamine D2 receptors reduces alcohol self-administration. J Neurochem 2001;78:1094-103.
14. Thanos PK, Taintor N, Hitzemann R, et al. The effect on ethanol drinking preference of D2 upregulation in the Nucleus Accumbens of the alcohol Preferring (P) and Non Preferring (NP) rats. Alcohol Clin Exp Res 2001;25 Suppl:56A.
15. Berger SP, Hall S, Mickalian JD, et al. Haloperidol antagonism of cue-elicited cocaine craving. Lancet 1996;347:504-508.
16. Farde L. The advantage of using positron emission tomography in drug research. Trends Neurosci 1996;19: 211-214.
17. 11C]Raclopride in the human brain. Synapse 1994;16: 255-262.
18. Volkow ND, Wang G-J, Fowler JS, et al. Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D2 receptors. J Pharmacol Exp Ther 1999;291:409-415.
19. Fischman MW, Schuster CR, Javaid J, et al. Acute tolerance development to the cardiovascular and subjective effects of cocaine. J Pharmacol Exp Ther 1985;235: 677-682.
20. Koob GF, Bloom FE. Cellular and molecular mechanisms of drug dependence. Science 1988;242:715-723.
21. Bradberry CW. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. J Neurosci 2000;20:7109-7115.
22. Moore RJ, Vinsant SL, Nader MA, et al. Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeys. Synapse 1998;30:88-96.
23. Volkow ND, Fowler JS, Wang G-J, et al. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse 1993; 14:169-177.
24. Volkow ND, Chang L, Wang G-J, et al. Decreased brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in orbitofrontal cortex. Am J Psychiatry 2001;158:2015-2021.
25. Volkow ND, Wang G-J, Fowler JS, et al. Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin Exp Res 1996;20:1594-1598.
26. Wang G-J, Volkow ND, Fowler JS, et al. Dopamine D2 receptors availability in opiate-dependent subjects before and after naloxone-precipitated withdrawal. Neuropsychopharmacology 1997;16:174-182.
27. Blum K, Cull JG, Braverman ER, et al. Reward deficiency syndrome. American Scientist 1996;84:132-145.
28. Salamone JD, Cousins MS, Snyder BJ. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci Biobehav Rev 1997;21:341-359.
29. Meguid MM, Fetissov SO, Varma M, et al. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition 2000; 16:843-857.
30. Tong Y, Pelletier G. Role of dopamine in the regulation of proopiomelanocortin (POMC) mRNA levels in the arcuate nucleus and pituitary gland of the female rat as studied by in situ hybridization. Brain Res Mol Brain Res 1992; 15:27-32.
31. Gillard ER, Dang DQ, Stanley BG. Evidence that neuropeptide Y and dopamine in the perifornical hypothalamus interact antagonistically in the control of food intake. Brain Res 1993;628:128-136.
32. Baskin DG, Figlewicz Lattemann D, et al. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res 1999;848:114-123.
33. Meguid MM, Fetissov SO, Blaha V, et al. Dopamine and serotonin VMN release is related to feeding status in obese and lean Zucker rats. Neuroreport 2000; 11:2069-2072.
34. Balcioglu A, Wurtman RJ. Effects of phentermine on striatal dopamine and serotonin release in conscious rats: in vivo microdialysis study. Int J Obes Relat Metab Disord 1998;22:325-328.
35. Martel P, Fantino M. Mesolimbic dopaminergic system activity as a function of food reward: a microdialysis study. Pharmacol Biochem Behav 1996;53:221-226.
36. Pothos E, Creese I, Hoebel B. Restricted eating with weight loss selectively decreases extracellular dopamine in the nucleus accumbens and alters dopamine response to amphetamine, morphine, and food intake. J Neurosci 1995; 15;6640-6650.
37. Berridge KC, Robinson TE. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 1998;28: 309-369.
38. Schwartz MW, Baskin DG, Kaiyala KJ, et al. Model for the regulation of energy balance and adiposity by the central nervous system. Am J Clin Nutr 1999;69:584-596.
39. Szczypka MS, Kwok K, Brot MD, et al. Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron 2001;30:819-828.
40. Bassareo V, Di Chiara G. Modulation of feeding-induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state. Eur J Neurosci 1999;11:4389-4397.
41. Volkow ND, Wang G-J, Fowler JS, et al. "Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect. Synapse 2002;44:175-180.
42. Spitzer RL, Yanovski S, Wadden T, et al. Binge eating disorder: its further validation in a multisite study. Int J Eat Disord 1993;13:137-153.
43. Goldfein JA, Walsh BT, LaChaussee JL, et al. Eating behavior in binge eating disorder. Int J Eat Disord 1993;14:427-431.
44. Yanovski SZ, Nelson JE, Dubbert BK, et al. Association of binge eating disorder and psychiatric comorbidity in obese subjects. Am J Psychiatry 1993;150:1472-1479.
45. Hsu LK, Sullivan SP, Benotti PN. Eating disturbances and outcome of gastric bypass surgery: a pilot study. Int J Eat Disord 1997;21:385-390.
46. Kalarchian MA, Wilson GT, Brolin RE, et al. Binge eating in bariatric surgery patients. Int J Eat Disord 1998;23:89-92.
47. Powers PS, Perez A, Boyd F, et al. Eating pathology before and after bariatric surgery: a prospective study. Int J Eat Disord 1999;25:293-300.
48. Saunders R. Binge eating in gastric bypass patients before surgery. Obes Surg 1999;9:72-76.
49. Dymek MP, le Grange D, Neven K, et al. Quality of life and psychosocial adjustment in patients after Roux-en-Y gastric bypass: a brief report. Obes Surg 2001; 11:32-39.
50. Kaye WH, Ballenger JC, Lydiard RB, et al. CSF monoamine levels in normal-weight bulimia: evidence for abnormal noradrenergic activity. Am J Psychiatry 1990;147:225-229.
51. Jimerson DC, Lesem MD, Kaye WH, et al. Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes. Arch Gen Psychiatry 1992;49:132-138.
52. Noble EP, Noble RE, Ritchie T, et al. D2 dopamine receptor gene and obesity. Int J Eat Disord 1994;15:205-217.
53. Laruelle M, Gelernter J, Innis RB. D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene. Mol Psychiatry, 1998;3:261-265.
54. Noble EP, Blum K, Ritchie T, et al. Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 1991;48:648-654.
55. Comings DE, Gade R, MacMurray JP, et al. Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric symptoms, and interaction with the dopamine D2 receptor (DRD2) gene. Mol Psychiatry 1996;1:325-335.
56. Noble EP, Fitch RJ, Ritchie T, et al. The D2 dopamine receptor gene: obesity, smoking and mood. In: St. Jeor ST, ed. Obesity Assessment. Chapman and Hall; New York; 1997;pp522-533.
57. Scislowski PW, Tozzo E, Zhang Y, et al. Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists. Int J Obes Relat Metab Disord 1999;23:425-431.
58. Allison DB, Casey DE. Antipsychotic-induced weight gain: a review of the literature. J Clin Psychiatry 2001;62Suppl7:22-31.
59. Wang G-J, Volkow ND, Logan J, et al. Brain dopamine and obesity. Lancet 2001;357:354-357.
60. Volkow ND, Wang G-J, Fowler JS, et al. Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. Am J Psychiatry 1999;156:1440-1443.
61. Volkow ND, Wang G-J, Fowler JS, et al. Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication study. Synapse. 2002;46:79-82.
62. Patel KA, Schlundt DG. Impact of moods and social context on eating behavior. Appetite 2001;36:111-118.
63. Volkow ND, Fowler JS. Neuropsychiatric disorders: Investigation of schizophrenia and substance abuse. Sem Nucl Med 1992;12:254-267.
64. Wang G-J, Volkow ND, Fowler JS, et al. Enhanced Metabolism in Oral Regions of Somatosensory Cortex in Obese Individuals. NeuroReport 2002;13:1151-1155.
65. Urasaki E, Uematsu S, Gordon B, Lesser RP. Cortical tongue area studied by chronically implanted subdural electrodes-with special reference to parietal motor and frontal sensory responses. Brain 1994;117(Pt 1):117-132.
66. Drewnowski A. Intense sweeteners and energy density of foods: implications for weight control. Eur J Clin Nutr 1999;53:757-763.
67. Yeomans MR. Palatability and the micro-structure of feeding in humans: the appetizer effect. Appetite 1996;27:119-133.
68. Cooper SJ. Beta-carbolines characterized as benzodiazepine receptor agonists and inverse agonists produce bi-directional changes in palatable food consumption. Brain Res Bull 1986;17:627-37.
69. Yeomans MR, Gray RW. Effects of naltrexone on food intake and changes in subjective appetite during eating: evidence for opioid involvement in the appetizer effect. Physiol Behav 1997;62:15-21.