Delineating the biosynthesis of gentamicin X2, the common precursor of the gentamicin C antibiotic complex

Chemistry and Biology

Volumn 22, Issue 2, 2015, Pages 251-261

  Huang, Chuan ^a   Huang, Fanglu ^b   Moison, Eileen ^b   Guo, Junhong ^a   Jian, Xinyun ^a   Duan, Xiaobo ^a   Deng, Zixin ^a,c   Leadlay, Peter F ^b   Sun, Yuhui ^a  

^a WUHAN UNIVERSITY   (China)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Wuhan Institute of Biotechnology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMINE; AMINOTRANSFERASE; COBALAMIN; GENTAMICIN; GENTAMICIN A2; GENTAMICIN C; GENTAMICIN X2; KANAMYCIN B; METHYLTRANSFERASE; OXIDOREDUCTASE; S ADENOSYLMETHIONINE; TOBRAMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; GENTAMICIN A; GENTAMICIN X(2); RECOMBINANT PROTEIN;

AMINATION; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; DEAMINATION; DRUG SYNTHESIS; ESCHERICHIA COLI; GENE CLUSTER; GENE MUTATION; IN VITRO STUDY; METHYLATION; MOLECULAR WEIGHT; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROMOTER REGION; SOUTHERN BLOTTING; TRANSAMINATION; BIOCATALYSIS; BIOSYNTHESIS; CHEMISTRY; GENETICS; ISOLATION AND PURIFICATION; METABOLISM;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

ANTI-BACTERIAL AGENTS; BIOCATALYSIS; ESCHERICHIA COLI; GENTAMICINS; METHYLATION; METHYLTRANSFERASES; OXIDOREDUCTASES; RECOMBINANT PROTEINS; TRANSAMINASES;

EID: 84923190178     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.12.012     Document Type: Article

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