GenK-catalyzed C-6′ methylation in the biosynthesis of gentamicin: Isolation and characterization of a cobalamin-dependent radical SAM enzyme

Journal of the American Chemical Society

Volumn 135, Issue 22, 2013, Pages 8093-8096

  Kim, Hak Joong ^a   McCarty, Reid M ^a   Ogasawara, Yasushi ^a   Liu, Yung Nan ^a   Mansoorabadi, Steven O ^a,b   Levieux, Jake ^a   Liu, Hung Wen ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTICS; AMINOGLYCOSIDES; BIOINFORMATIC ANALYSIS; ISOLATION AND CHARACTERIZATION; METHYLATION REACTION; METHYLTRANSFERASES; REACTION MECHANISM; S ADENOSYL L METHIONINES;

ALKYLATION; AMINO ACIDS; BIOCHEMISTRY; BIOINFORMATICS; BIOSYNTHESIS; CATALYSIS; EXPERIMENTS; FUNCTIONAL GROUPS; ISOTOPES; METHYLATION; STOICHIOMETRY;

ENZYMES;

ADENOSINE DERIVATIVE; ADENOSYLHOMOCYSTEINASE; COBALAMIN; GENTAMICIN; METHYLTRANSFERASE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL REACTION; ISOTOPE LABELING; METHYLATION; MOLECULAR MECHANICS; STOICHIOMETRY;

BIOCATALYSIS; FREE RADICALS; GENTAMICINS; METHYLATION; METHYLTRANSFERASES; S-ADENOSYLMETHIONINE; VITAMIN B 12;

EID: 84878651511     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja312641f     Document Type: Article

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