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Volumn 62, Issue 9, 2009, Pages 471-481

Biosynthetic genes for aminoglycoside antibiotics

Author keywords

Aminocyclitol; Aminoglycoside antibiotics; Biosynthesis; Biosynthetic enzyme; Biosynthetic gene

Indexed keywords

2 DEOXYSTREPTAMINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; APRAMYCIN; ASTROMICIN; BLUENSOMYCIN; BUTIROSIN; FORTIMICIN; GENTAMICIN; HYGROMYCIN; ISTAMYCIN A; KANAMYCIN; KASUGAMYCIN; NEOMYCIN; SPECTINOMYCIN; STREPTOMYCIN;

EID: 70349596297     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2009.76     Document Type: Review
Times cited : (83)

References (44)
  • 1
    • 70349606300 scopus 로고    scopus 로고
    • Aminoglycoside Antibiotics
    • ed Arya, D.P. John Wiley & Sons Inc., Hoboken, NJ
    • Davies, J. in Aminoglycoside Antibiotics. In the beginning there was streptomycin (ed Arya, D.P.) 1-13 (John Wiley & Sons Inc., Hoboken, NJ, 2007).
    • (2007) In the Beginning There Was Streptomycin , pp. 1-13
    • Davies, J.1
  • 2
    • 0034699519 scopus 로고    scopus 로고
    • Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
    • Carter, A. P. et al. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature 407, 340-348 (2000).
    • (2000) Nature , vol.407 , pp. 340-348
    • Carter, A.P.1
  • 3
    • 0032828903 scopus 로고    scopus 로고
    • Aminoglycoside-modifying enzymes
    • Wright, G. D. Aminoglycoside-modifying enzymes. Curr. Opin. Microbiol. 2, 499-503 (1999).
    • (1999) Curr. Opin. Microbiol. , vol.2 , pp. 499-503
    • Wright, G.D.1
  • 4
    • 67649165917 scopus 로고    scopus 로고
    • Mechanisms of aminoglycoside antibiotic resistance
    • ed. Arya, D. P. John Wiley & Sons Inc., Hoboken, NJ
    • Shakya, T. & Wright, G. D. Mechanisms of aminoglycoside antibiotic resistance. in Aminoglycoside Antibiotics (ed. Arya, D. P.) 119-140 (John Wiley & Sons Inc., Hoboken, NJ, 2007).
    • (2007) Aminoglycoside Antibiotics , pp. 119-140
    • Shakya, T.1    Wright, G.D.2
  • 5
    • 0032892950 scopus 로고    scopus 로고
    • Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications
    • Kondo, S. & Hotta, K. Semisynthetic aminoglycoside antibiotics: development and enzymatic modifications. J. Infect. Chemother. 5, 1-9 (1999).
    • (1999) J. Infect. Chemother. , vol.5 , pp. 1-9
    • Kondo, S.1    Hotta, K.2
  • 6
    • 70349601881 scopus 로고    scopus 로고
    • Targeting HIV-1 RNA with Aminoglycoside antibiotics and their derivatives
    • ed. Arya, D. P. John Wiley & Sons Inc., Hoboken, NJ
    • Elson-Schwab, L. & Tor, Y. Targeting HIV-1 RNA with Aminoglycoside antibiotics and their derivatives. in Aminoglycoside Antibiotics (ed. Arya, D. P.) 267-287 (John Wiley & Sons Inc., Hoboken, NJ, 2007).
    • (2007) Aminoglycoside Antibiotics , pp. 267-287
    • Elson-Schwab, L.1    Tor, Y.2
  • 7
    • 9644281382 scopus 로고    scopus 로고
    • Combating drug-resistant bacteria: Small molecule mimics of plasmid incompatibility as antiplasmid compounds
    • Denap, J. C., Thomas, J. R., Musk, D. J. & Hergenrother, P. J. Combating drug-resistant bacteria: small molecule mimics of plasmid incompatibility as antiplasmid compounds. J. Am. Chem. Soc. 126, 15402-15404 (2004).
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 15402-15404
    • Denap, J.C.1    Thomas, J.R.2    Musk, D.J.3    Hergenrother, P.J.4
  • 8
    • 43149103943 scopus 로고    scopus 로고
    • Targeting RNA with small molecules
    • Thomas, J. R. & Hergenrother, P. J. Targeting RNA with small molecules. Chem. Rev. 108, 1171-1224 (2008).
    • (2008) Chem. Rev. , vol.108 , pp. 1171-1224
    • Thomas, J.R.1    Hergenrother, P.J.2
  • 9
    • 0016946294 scopus 로고
    • Biosynthesis of aminocyclitol antibiotics
    • Rinehart, Jr. K. L. & Stroshane, R. M. Biosynthesis of aminocyclitol antibiotics. J. Antibiot. 29, 319-353 (1976).
    • (1976) J. Antibiot. , vol.29 , pp. 319-353
    • Rinehart Jr., K.L.1    Stroshane, R.M.2
  • 10
    • 0018590824 scopus 로고
    • Biosynthesis and mutasynthesis of aminocyclitol antibiotics
    • Rinehart, Jr. K. L. Biosynthesis and mutasynthesis of aminocyclitol antibiotics. J. Antibiot. 32, S32-S46 (1979).
    • (1979) J. Antibiot. , vol.32
    • Rinehart Jr., K.L.1
  • 11
    • 0018626275 scopus 로고
    • Biosynthesis of butirosins. II. Biosynthetic pathway of butirosins elucidated from cosynthesis and feeding experiments
    • Furumai, T., Takeda, K., Kinumaki, A., Ito, Y. & Okuda, T. Biosynthesis of butirosins. II. Biosynthetic pathway of butirosins elucidated from cosynthesis and feeding experiments. J. Antibiot. 32, 891-899 (1979).
    • (1979) J. Antibiot. , vol.32 , pp. 891-899
    • Furumai, T.1    Takeda, K.2    Kinumaki, A.3    Ito, Y.4    Okuda, T.5
  • 12
    • 0028936482 scopus 로고
    • Enzymic synthesis of aminocyclitol moieties of aminoglycoside antibiotics from inositol by Streptomyces spp.: Detection of glutamine-aminocyclitol aminotrans-ferase and diaminocyclitol aminotransferase activities in a spectinomycin producer
    • Walker, J. B. Enzymic synthesis of aminocyclitol moieties of aminoglycoside antibiotics from inositol by Streptomyces spp.: detection of glutamine-aminocyclitol aminotrans-ferase and diaminocyclitol aminotransferase activities in a spectinomycin producer. J. Bacteriol. 177, 818-822 (1995).
    • (1995) J. Bacteriol. , vol.177 , pp. 818-822
    • Walker, J.B.1
  • 13
    • 0023355091 scopus 로고
    • Gene cluster for streptomycin biosynthesis in Streptomyces griseus: Analysis of a central region including the major resistance gene
    • Distler, J., Braun, C., Ebert, A. & Piepersberg, W. Gene cluster for streptomycin biosynthesis in Streptomyces griseus: analysis of a central region including the major resistance gene. Mol. Gen. Genet. 208, 204-210 (1987).
    • (1987) Mol. Gen. Genet. , vol.208 , pp. 204-210
    • Distler, J.1    Braun, C.2    Ebert, A.3    Piepersberg, W.4
  • 14
    • 0026656737 scopus 로고
    • Streptomycin biosynthesis and its regulation in Streptomycetes
    • Distler, J., Mansouri, K., Mayer, G., Stockmann, M. & Piepersberg, W. Streptomycin biosynthesis and its regulation in Streptomycetes. Gene 115, 105-111 (1992).
    • (1992) Gene , vol.115 , pp. 105-111
    • Distler, J.1    Mansouri, K.2    Mayer, G.3    Stockmann, M.4    Piepersberg, W.5
  • 15
    • 0030814692 scopus 로고    scopus 로고
    • Identification of stsC, the gene encoding the L-glutamine:scyllo-inosose aminotransferase from streptomycin-producing Streptomycetes
    • Ahlert, J., Distler, J., Mansouri, K. & Piepersberg, W. Identification of stsC, the gene encoding the L-glutamine:scyllo-inosose aminotransferase from streptomycin-producing Streptomycetes. Arch. Microbiol. 168, 102-113 (1997).
    • (1997) Arch. Microbiol. , vol.168 , pp. 102-113
    • Ahlert, J.1    Distler, J.2    Mansouri, K.3    Piepersberg, W.4
  • 16
    • 0032559012 scopus 로고    scopus 로고
    • Crystal structure of L-arginine:inosamine-phosphate amidinotransferase StrB1 from Streptomyces griseus: An enzyme involved in streptomycin biosynthesis
    • Fritsche, E., Bergner, A., Humm, A., Piepersberg, W. & Huber, R. Crystal structure of L-arginine:inosamine-phosphate amidinotransferase StrB1 from Streptomyces griseus: an enzyme involved in streptomycin biosynthesis. Biochemistry 37, 17664-17672 (1998).
    • (1998) Biochemistry , vol.37 , pp. 17664-17672
    • Fritsche, E.1    Bergner, A.2    Humm, A.3    Piepersberg, W.4    Huber, R.5
  • 17
    • 0032535353 scopus 로고    scopus 로고
    • The StrQ protein encoded in the gene cluster for 5¢- hydroxystreptomycin of Streptomyces glaucescens GLA.0 is a alpha-D-glucose-1- phosphate cytidylyltransferase (CDP-D-glucose synthase)
    • Beyer, S., Mayer, G. & Piepersberg, W. The StrQ protein encoded in the gene cluster for 5¢-hydroxystreptomycin of Streptomyces glaucescens GLA.0 is a alpha-D-glucose-1-phosphate cytidylyltransferase (CDP-D-glucose synthase). Eur. J. Biochem. 258, 1059-1067 (1998).
    • (1998) Eur. J. Biochem. , vol.258 , pp. 1059-1067
    • Beyer, S.1    Mayer, G.2    Piepersberg, W.3
  • 18
    • 0034645602 scopus 로고    scopus 로고
    • Engineering a hybrid sugar biosynthetic pathway: Production of L-rhamnose and its implication on dihydrostreptose biosynthesis
    • Yamase, H., Zhao, L. & Liu, H.-w. Engineering a hybrid sugar biosynthetic pathway: production of L-rhamnose and its implication on dihydrostreptose biosynthesis. J. Am. Chem. Soc. 122, 12397-12398 (2000).
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 12397-12398
    • Yamase, H.1    Zhao, L.2    Liu, H.-W.3
  • 19
    • 0033055677 scopus 로고    scopus 로고
    • Purification and characterization of 2-deoxy-scyllo-inosose synthase derived from Bacillus circulans. A crucial carbocycli-zation enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics
    • Kudo, F., Hosomi, Y., Tamegai, H. & Kakinuma, K. Purification and characterization of 2-deoxy-scyllo-inosose synthase derived from Bacillus circulans. A crucial carbocycli-zation enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics. J. Antibiot. 52, 81-88 (1999).
    • (1999) J. Antibiot. , vol.52 , pp. 81-88
    • Kudo, F.1    Hosomi, Y.2    Tamegai, H.3    Kakinuma, K.4
  • 20
    • 0032854187 scopus 로고    scopus 로고
    • Molecular cloning of the gene for the key carbocycle-forming enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics and its comparison with dehydroquinate synthase
    • Kudo, F. et al. Molecular cloning of the gene for the key carbocycle-forming enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics and its comparison with dehydroquinate synthase. J. Antibiot. 52, 559-571 (1999).
    • (1999) J. Antibiot. , vol.52 , pp. 559-571
    • Kudo, F.1
  • 21
    • 0033762284 scopus 로고    scopus 로고
    • Butirosin-biosynthetic gene cluster from Bacillus circulans
    • Ota, Y. et al. Butirosin-biosynthetic gene cluster from Bacillus circulans. J. Antibiot. 53, 1158-1167 (2000).
    • (2000) J. Antibiot. , vol.53 , pp. 1158-1167
    • Ota, Y.1
  • 22
    • 64049089984 scopus 로고    scopus 로고
    • Biosynthetic enzymes for the aminoglycosides butirosin and neomycin
    • Kudo, F. & Eguchi, T. Biosynthetic enzymes for the aminoglycosides butirosin and neomycin. Methods Enzymol. 459, 493-519 (2009).
    • (2009) Methods Enzymol. , vol.459 , pp. 493-519
    • Kudo, F.1    Eguchi, T.2
  • 23
    • 64049109362 scopus 로고    scopus 로고
    • The biochemistry and genetics of aminoglycoside producers
    • ed. Arya, D. P. John Wiley & Sons Inc., Hoboken, NJ
    • Piepersberg, W., Aboshanab, K. M., Schmidt-Beissner, H. & Wehmeier, U. F. The biochemistry and genetics of aminoglycoside producers. in Aminoglycoside Antibiotics (ed. Arya, D. P.) 15-118 (John Wiley & Sons Inc., Hoboken, NJ, 2007).
    • (2007) Aminoglycoside Antibiotics , pp. 15-118
    • Piepersberg, W.1    Aboshanab, K.M.2    Schmidt-Beissner, H.3    Wehmeier, U.F.4
  • 25
    • 0036436618 scopus 로고    scopus 로고
    • Biosynthesis of aminoglycoside antibiotics: Cloning, expression and characterization of an aminotransferase involved in the pathway to 2-deoxystreptamine
    • Huang, F., Li, Y., Yu, J. & Spencer, J. B. Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterization of an aminotransferase involved in the pathway to 2-deoxystreptamine. Chem. Commun. 2860-2861 (2002).
    • (2002) Chem. Commun. , pp. 2860-2861
    • Huang, F.1    Li, Y.2    Yu, J.3    Spencer, J.B.4
  • 26
    • 31444455929 scopus 로고    scopus 로고
    • Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773
    • Kudo, F., Yamamoto, Y., Yokoyama, K., Eguchi, T. & Kakinuma, K. Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773. J. Antibiot. 58, 766-774 (2005).
    • (2005) J. Antibiot. , vol.58 , pp. 766-774
    • Kudo, F.1    Yamamoto, Y.2    Yokoyama, K.3    Eguchi, T.4    Kakinuma, K.5
  • 27
    • 17744378979 scopus 로고    scopus 로고
    • Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis
    • Yokoyama, K. et al. Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis. J. Am. Chem. Soc. 127, 5869-5874 (2005).
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 5869-5874
    • Yokoyama, K.1
  • 28
    • 44049095529 scopus 로고    scopus 로고
    • Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis
    • Yokoyama, K., Yamamoto, Y., Kudo, F. & Eguchi, T. Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis. Chembiochem. 9, 865-869 (2008).
    • (2008) Chembiochem. , vol.9 , pp. 865-869
    • Yokoyama, K.1    Yamamoto, Y.2    Kudo, F.3    Eguchi, T.4
  • 29
    • 34547562892 scopus 로고    scopus 로고
    • Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin
    • Huang, F. et al. Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. Chembiochem. 8, 283-288 (2007).
    • (2007) Chembiochem. , vol.8 , pp. 283-288
    • Huang, F.1
  • 30
    • 34248652943 scopus 로고    scopus 로고
    • Unique O-ribosylation in the biosynthesis of butirosin
    • Kudo, F., Fujii, T., Kinoshita, S. & Eguchi, T. Unique O-ribosylation in the biosynthesis of butirosin. Bioorg. Med. Chem. 15, 4360-4368 (2007).
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 4360-4368
    • Kudo, F.1    Fujii, T.2    Kinoshita, S.3    Eguchi, T.4
  • 31
    • 24944561674 scopus 로고    scopus 로고
    • Biosynthesis of the unique amino acid side chain of butirosin: Possible protective-group chemistry in an acyl carrier protein-mediated pathway
    • Li, Y., Llewellyn, N. M., Giri, R., Huang, F. & Spencer, J. B. Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway. Chem. Biol. 12, 665-675 (2005).
    • (2005) Chem. Biol. , vol.12 , pp. 665-675
    • Li, Y.1    Llewellyn, N.M.2    Giri, R.3    Huang, F.4    Spencer, J.B.5
  • 32
    • 34247198471 scopus 로고    scopus 로고
    • Biosynthesis of butirosin: Transfer and deprotection of the unique amino acid side chain
    • Llewellyn, N. M., Li, Y. & Spencer, J. B. Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain. Chem. Biol. 14, 379-386 (2007).
    • (2007) Chem. Biol. , vol.14 , pp. 379-386
    • Llewellyn, N.M.1    Li, Y.2    Spencer, J.B.3
  • 33
    • 37049024768 scopus 로고    scopus 로고
    • Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin
    • Yokoyama, K., Numakura, M., Kudo, F., Ohmori, D. & Eguchi, T. Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin. J. Am. Chem. Soc. 129, 15147-15155 (2007).
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 15147-15155
    • Yokoyama, K.1    Numakura, M.2    Kudo, F.3    Ohmori, D.4    Eguchi, T.5
  • 34
    • 58549102566 scopus 로고    scopus 로고
    • Expanding substrate specificity of GT-B fold glycosyltransferase via domain swapping and high-throughput screening
    • Park, S. H. et al. Expanding substrate specificity of GT-B fold glycosyltransferase via domain swapping and high-throughput screening. Biotechnol. Bioeng. 102, 988-994 (2009).
    • (2009) Biotechnol. Bioeng. , vol.102 , pp. 988-994
    • Park, S.H.1
  • 35
    • 66649109099 scopus 로고    scopus 로고
    • Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853
    • Nepal, K. K., Oh, T. J. & Sohng, J. K. Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853. Mol. Cells 27, 601-608 (2009).
    • (2009) Mol. Cells , vol.27 , pp. 601-608
    • Nepal, K.K.1    Oh, T.J.2    Sohng, J.K.3
  • 36
    • 59149095036 scopus 로고    scopus 로고
    • Molecular cloning and sequence analysis of the sisomicin bio-synthetic gene cluster from Micromonospora inyoensis
    • Hong, W. R. et al. Molecular cloning and sequence analysis of the sisomicin bio-synthetic gene cluster from Micromonospora inyoensis. Biotechnol. Lett. 31, 449-455 (2009).
    • (2009) Biotechnol. Lett. , vol.31 , pp. 449-455
    • Hong, W.R.1
  • 37
    • 46149125940 scopus 로고    scopus 로고
    • Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set
    • Park, J. W. et al. Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set. Proc. Natl Acad. Sci. USA 105, 8399-8404 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 8399-8404
    • Park, J.W.1
  • 38
    • 45449088302 scopus 로고    scopus 로고
    • Gene inactivation study of gntE reveals its role in the first step of pseudotrisaccharide modifications in gentamicin biosynthesis
    • Kim, J. Y. et al. Gene inactivation study of gntE reveals its role in the first step of pseudotrisaccharide modifications in gentamicin biosynthesis. Biochem. Biophys. Res. Commun. 372, 730-734 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.372 , pp. 730-734
    • Kim, J.Y.1
  • 39
    • 0028858189 scopus 로고
    • Nucleotide sequence of fortimicin KL1 methyltransferase gene isolated from Micromonospora olivasterospora, and comparison of its deduced amino acid sequence with those of methyltransferases involved in the biosynthesis of bialaphos and fosfomycin
    • Kuzuyama, T., Seki, T., Dairi, T., Hidaka, T. & Seto, H. Nucleotide sequence of fortimicin KL1 methyltransferase gene isolated from Micromonospora olivasterospora, and comparison of its deduced amino acid sequence with those of methyltransferases involved in the biosynthesis of bialaphos and fosfomycin. J. Antibiot. 48, 1191-1193 (1995).
    • (1995) J. Antibiot. , vol.48 , pp. 1191-1193
    • Kuzuyama, T.1    Seki, T.2    Dairi, T.3    Hidaka, T.4    Seto, H.5
  • 40
    • 50249136542 scopus 로고    scopus 로고
    • The gene cluster for spectinomycin biosynthesis and the aminoglycoside-resistance function of spcM in Streptomyces spectabilis
    • Kim, K. R., Kim, T. J. & Suh, J. W. The gene cluster for spectinomycin biosynthesis and the aminoglycoside-resistance function of spcM in Streptomyces spectabilis. Curr. Microbiol. 57, 371-374 (2008).
    • (2008) Curr. Microbiol. , vol.57 , pp. 371-374
    • Kim, K.R.1    Kim, T.J.2    Suh, J.W.3
  • 41
    • 69949123857 scopus 로고    scopus 로고
    • DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus
    • Hara, H., Ohnishi, Y. & Horinouchi, S. DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus. Microbiology 155, 2197-2210 (2009).
    • (2009) Microbiology , vol.155 , pp. 2197-2210
    • Hara, H.1    Ohnishi, Y.2    Horinouchi, S.3
  • 42
    • 33644519643 scopus 로고    scopus 로고
    • DNA sequencing and transcriptional analysis of the kasugamycin biosynthetic gene cluster from Strepto-myces kasugaensis M338-M1
    • Ikeno, S., Aoki, D., Hamada, M., Hori, M. & Tsuchiya, K. S. DNA sequencing and transcriptional analysis of the kasugamycin biosynthetic gene cluster from Strepto-myces kasugaensis M338-M1. J. Antibiot. 59, 18-28 (2006).
    • (2006) J. Antibiot. , vol.59 , pp. 18-28
    • Ikeno, S.1    Aoki, D.2    Hamada, M.3    Hori, M.4    Tsuchiya, K.S.5
  • 43
    • 0016412359 scopus 로고
    • Pathways of biosynthesis of the guanidinated inositol moieties of streptomycin and bluensomycin
    • Walker, J. B. Pathways of biosynthesis of the guanidinated inositol moieties of streptomycin and bluensomycin. Methods Enzymol. 43, 429-433 (1975).
    • (1975) Methods Enzymol. , vol.43 , pp. 429-433
    • Walker, J.B.1
  • 44
    • 44849132618 scopus 로고    scopus 로고
    • Biosynthesis of spectinomycin: Heterologous production of spectinomycin and spectinamine in an aminoglycoside-deficient host, Streptomyces venezuelae YJ003
    • Thapa, L. P., Oh, T. J., Liou, K. & Sohng, J. K. Biosynthesis of spectinomycin: heterologous production of spectinomycin and spectinamine in an aminoglycoside-deficient host, Streptomyces venezuelae YJ003. J. Appl. Microbiol. 105, 300-308 (2008).
    • (2008) J. Appl. Microbiol. , vol.105 , pp. 300-308
    • Thapa, L.P.1    Oh, T.J.2    Liou, K.3    Sohng, J.K.4


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