-
1
-
-
84984999069
-
Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR
-
Braeuning A., Gavrilov A., Brown S., Wolf C.R., Henderson C.J., Schwarz M. Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. Toxicol. Sci 2014, 140:259-270.
-
(2014)
Toxicol. Sci
, vol.140
, pp. 259-270
-
-
Braeuning, A.1
Gavrilov, A.2
Brown, S.3
Wolf, C.R.4
Henderson, C.J.5
Schwarz, M.6
-
2
-
-
84899822044
-
Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action
-
Currie R.A., Peffer R.C., Goetz A.K., Omiecinski C.J., Goodman J.I. Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action. Toxicology 2014, 321:80-88.
-
(2014)
Toxicology
, vol.321
, pp. 80-88
-
-
Currie, R.A.1
Peffer, R.C.2
Goetz, A.K.3
Omiecinski, C.J.4
Goodman, J.I.5
-
3
-
-
0022990896
-
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice
-
Diwan B.A., Rice J.M., Ohshima M., Ward J.M. Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice. Carcinogenesis 1986, 7:215-220.
-
(1986)
Carcinogenesis
, vol.7
, pp. 215-220
-
-
Diwan, B.A.1
Rice, J.M.2
Ohshima, M.3
Ward, J.M.4
-
4
-
-
84891503154
-
Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: a case study with phenobarbital as a model constitutive androstane receptor (CAR) activator
-
Elcombe C.R., Peffer R.C., Wolf D.C., Bailey J., Bars R., Bell D., et al. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: a case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Crit. Rev. Toxicol 2014, 44:64-82.
-
(2014)
Crit. Rev. Toxicol
, vol.44
, pp. 64-82
-
-
Elcombe, C.R.1
Peffer, R.C.2
Wolf, D.C.3
Bailey, J.4
Bars, R.5
Bell, D.6
-
5
-
-
0032882718
-
Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
-
Ghannoum M.A., Rice L.B. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Rev 1999, 12:501-517.
-
(1999)
Clin. Microbiol. Rev
, vol.12
, pp. 501-517
-
-
Ghannoum, M.A.1
Rice, L.B.2
-
6
-
-
84867070577
-
Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes - conclusions from the 3rd International ESTP Expert Workshop
-
Hall A.P., Elcombe C.R., Foster J.R., Harada T., Kaufmann W., Knippel A., et al. Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes - conclusions from the 3rd International ESTP Expert Workshop. Toxicol. Pathol 2012, 40:971-994.
-
(2012)
Toxicol. Pathol
, vol.40
, pp. 971-994
-
-
Hall, A.P.1
Elcombe, C.R.2
Foster, J.R.3
Harada, T.4
Kaufmann, W.5
Knippel, A.6
-
7
-
-
29544450979
-
Mode of action in relevance of rodent liver tumors to human cancer risk
-
Holsapple M.P., Pitot H.C., Cohen S.M., Boobis A.R., Klaunig J.E., Pastoor T., et al. Mode of action in relevance of rodent liver tumors to human cancer risk. Toxicol. Sci 2006, 89:51-56.
-
(2006)
Toxicol. Sci
, vol.89
, pp. 51-56
-
-
Holsapple, M.P.1
Pitot, H.C.2
Cohen, S.M.3
Boobis, A.R.4
Klaunig, J.E.5
Pastoor, T.6
-
8
-
-
22344451423
-
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor
-
Huang W., Zhang J., Washington M., Liu J., Parant J.M., Lozano G., et al. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol. Endocrinol 2005, 19:1646-1653.
-
(2005)
Mol. Endocrinol
, vol.19
, pp. 1646-1653
-
-
Huang, W.1
Zhang, J.2
Washington, M.3
Liu, J.4
Parant, J.M.5
Lozano, G.6
-
9
-
-
29544433631
-
Phenobarbital and its sodium salt
-
International Agency for Research on Cancer (IARC) Phenobarbital and its sodium salt. IARC Monogr. Eval. Carcinog. Risks Hum 2001, 79.
-
(2001)
IARC Monogr. Eval. Carcinog. Risks Hum
, vol.79
-
-
-
10
-
-
84923208625
-
-
Propiconazole (Pesticide residues in food: 1987 evaluations Part II Toxicology), accessed 12.02.15
-
INCHEM Monograph 768 Propiconazole (Pesticide residues in food: 1987 evaluations Part II Toxicology), accessed 12.02.15. http://www.inchem.org/documents/jmpr/jmpmono/v87pr13.htm.
-
Monograph 768
-
-
-
11
-
-
84923208624
-
-
Myclobutanil (Pesticide residues in food: 1992 evaluations Part II Toxicology), accessed 12.02.15
-
INCHEM Monograph 847 Myclobutanil (Pesticide residues in food: 1992 evaluations Part II Toxicology), accessed 12.02.15. http://www.inchem.org/documents/jmpr/jmpmono/v92pr13.htm.
-
Monograph 847
-
-
-
12
-
-
84923208623
-
-
Tebuconazole (Pesticide residues in food: 1994 evaluations Part II Toxicology), accessed 12.02.15
-
INCHEM Monograph 884 Tebuconazole (Pesticide residues in food: 1994 evaluations Part II Toxicology), accessed 12.02.15. http://www.inchem.org/documents/jmpr/jmpmono/v94pr10.htm.
-
Monograph 884
-
-
-
13
-
-
84923208622
-
-
Fenbuconazole (Pesticide residues in food: 1997 evaluations Part II Toxicological & Environmental), accessed 12.02.15
-
INCHEM Monograph 930 Fenbuconazole (Pesticide residues in food: 1997 evaluations Part II Toxicological & Environmental), accessed 12.02.15. http://www.inchem.org/documents/jmpr/jmpmono/v097pr07.htm.
-
Monograph 930
-
-
-
14
-
-
84923208621
-
-
In JMPR Monographs 2001, accessed 12.02.15
-
INCHEM Toxicological evaluations IMAZILIL (Addendum) In JMPR Monographs 2001, accessed 12.02.15. http://www.inchem.org/documents/jmpr/jmpmono/2001pr06.htm.
-
Toxicological evaluations IMAZILIL (Addendum)
-
-
-
15
-
-
80054789575
-
The role of a novel CAR-induced gene TUBA8 in hepatocellular carcinoma cell lines
-
Kamino H., Moore R., Negishi M. The role of a novel CAR-induced gene TUBA8 in hepatocellular carcinoma cell lines. Cancer Genet 2011, 204:382-391.
-
(2011)
Cancer Genet
, vol.204
, pp. 382-391
-
-
Kamino, H.1
Moore, R.2
Negishi, M.3
-
17
-
-
4444246000
-
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes
-
Kodama S., Koike C., Negishi M., Yamamoto Y. Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. Mol. Cell. Biol 2004, 24:7931-7940.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 7931-7940
-
-
Kodama, S.1
Koike, C.2
Negishi, M.3
Yamamoto, Y.4
-
18
-
-
84889257393
-
A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer
-
La Vecchia C., Negri E. A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer. Eur. J. Cancer Prev 2014, 23:1-7.
-
(2014)
Eur. J. Cancer Prev
, vol.23
, pp. 1-7
-
-
La Vecchia, C.1
Negri, E.2
-
19
-
-
0036245244
-
Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients
-
Lamminpää A., Pukkala E., Teppo L., Neuvonen P.J. Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients. Eur. J. Clin. Pharmacol 2002, 58:137-141.
-
(2002)
Eur. J. Clin. Pharmacol
, vol.58
, pp. 137-141
-
-
Lamminpää, A.1
Pukkala, E.2
Teppo, L.3
Neuvonen, P.J.4
-
20
-
-
84899944047
-
Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors
-
Luisier R., Lempiäinen H., Scherbichler N., Braeuning A., Geissler M., Dubost V., et al. Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors. Toxicol. Sci 2014, 139:501-511.
-
(2014)
Toxicol. Sci
, vol.139
, pp. 501-511
-
-
Luisier, R.1
Lempiäinen, H.2
Scherbichler, N.3
Braeuning, A.4
Geissler, M.5
Dubost, V.6
-
21
-
-
67649224671
-
Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression
-
Nesnow S., Ward W., Moore T., Ren H., Hester S.D. Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression. Toxicol. Sci 2009, 110:68-83.
-
(2009)
Toxicol. Sci
, vol.110
, pp. 68-83
-
-
Nesnow, S.1
Ward, W.2
Moore, T.3
Ren, H.4
Hester, S.D.5
-
22
-
-
80053479216
-
Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats
-
Ozawa S., Gamou T., Habano W., Inoue K., Yoshida M., Nishikawa A., et al. Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats. J. Toxicol. Sci 2011, 36:613-623.
-
(2011)
J. Toxicol. Sci
, vol.36
, pp. 613-623
-
-
Ozawa, S.1
Gamou, T.2
Habano, W.3
Inoue, K.4
Yoshida, M.5
Nishikawa, A.6
-
23
-
-
1642602694
-
Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2
-
Papa S., Zazzeroni F., Bubici C., Jayawardena S., Alvarez K., Matsuda S., et al. Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. Nat. Cell Biol 2004, 6:146-153.
-
(2004)
Nat. Cell Biol
, vol.6
, pp. 146-153
-
-
Papa, S.1
Zazzeroni, F.2
Bubici, C.3
Jayawardena, S.4
Alvarez, K.5
Matsuda, S.6
-
24
-
-
34547102525
-
Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2
-
Papa S., Monti S.M., Vitale R.M., Bubici C., Jayawardena S., Alvarez K., et al. Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2. J. Biol. Chem 2007, 282:19029-19041.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 19029-19041
-
-
Papa, S.1
Monti, S.M.2
Vitale, R.M.3
Bubici, C.4
Jayawardena, S.5
Alvarez, K.6
-
25
-
-
34547895454
-
Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor
-
Peffer R.C., Moggs J.G., Pastoor T., Currie R.A., Wright J., Milburn G., et al. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol. Sci 2007, 99:315-325.
-
(2007)
Toxicol. Sci
, vol.99
, pp. 315-325
-
-
Peffer, R.C.1
Moggs, J.G.2
Pastoor, T.3
Currie, R.A.4
Wright, J.5
Milburn, G.6
-
26
-
-
67650735625
-
The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors
-
Phillips J.M., Burgoon L.D., Goodman J.I. The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors. Toxicol. Sci 2009, 110:319-333.
-
(2009)
Toxicol. Sci
, vol.110
, pp. 319-333
-
-
Phillips, J.M.1
Burgoon, L.D.2
Goodman, J.I.3
-
27
-
-
85010175361
-
Summary of toxicological studies on cyproconazole
-
Regulatory Affairs Department, SDS Biotech K.K. Summary of toxicological studies on cyproconazole. J. Pest. Sci 1997, 22:263-268.
-
(1997)
J. Pest. Sci
, vol.22
, pp. 263-268
-
-
-
28
-
-
77955084537
-
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo
-
Ross J., Plummer S.M., Rode A., Scheer N., Bower C.C., Vogel O., et al. Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. Toxicol. Sci 2010, 116:452-466.
-
(2010)
Toxicol. Sci
, vol.116
, pp. 452-466
-
-
Ross, J.1
Plummer, S.M.2
Rode, A.3
Scheer, N.4
Bower, C.C.5
Vogel, O.6
-
29
-
-
84887589918
-
Different pathways of constitutive androstane receptor-mediated liver hypertrophy and hepatocarcinogenesis in mice treated with piperonyl butoxide or decabromodiphenyl ether
-
Sakamoto Y., Inoue K., Takahashi M., Taketa Y., Kodama Y., Nemoto K., et al. Different pathways of constitutive androstane receptor-mediated liver hypertrophy and hepatocarcinogenesis in mice treated with piperonyl butoxide or decabromodiphenyl ether. Toxicol. Pathol 2013, 41:1078-1092.
-
(2013)
Toxicol. Pathol
, vol.41
, pp. 1078-1092
-
-
Sakamoto, Y.1
Inoue, K.2
Takahashi, M.3
Taketa, Y.4
Kodama, Y.5
Nemoto, K.6
-
30
-
-
33646114052
-
Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice
-
Sun G., Thai S.F., Lambert G.R., Wolf D.C., Tully D.B., Goetz A.K., et al. Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice. Toxicol. Lett 2006, 164:44-53.
-
(2006)
Toxicol. Lett
, vol.164
, pp. 44-53
-
-
Sun, G.1
Thai, S.F.2
Lambert, G.R.3
Wolf, D.C.4
Tully, D.B.5
Goetz, A.K.6
-
31
-
-
84879758415
-
Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides
-
Tamura K., Inoue K., Takahashi M., Matsuo S., Irie K., Kodama Y., et al. Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides. Toxicol. Lett 2013, 221:47-56.
-
(2013)
Toxicol. Lett
, vol.221
, pp. 47-56
-
-
Tamura, K.1
Inoue, K.2
Takahashi, M.3
Matsuo, S.4
Irie, K.5
Kodama, Y.6
-
32
-
-
79751488721
-
Proliferative and nonneoplastic lesions of the rat and mouse hepatobiliary system
-
Thoolen B., Maronpot R.R., Harada T., Nyska A., Rousseaux C., Nolte T., et al. Proliferative and nonneoplastic lesions of the rat and mouse hepatobiliary system. Toxicol. Pathol 2010, 38(7 Suppl.):5S-81S.
-
(2010)
Toxicol. Pathol
, vol.38
, Issue.7
, pp. 5S-81S
-
-
Thoolen, B.1
Maronpot, R.R.2
Harada, T.3
Nyska, A.4
Rousseaux, C.5
Nolte, T.6
-
33
-
-
0034687397
-
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
-
Wei P., Zhang J., Egan-Hafley M., Liang S., Moore D.D. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 2000, 407:920-923.
-
(2000)
Nature
, vol.407
, pp. 920-923
-
-
Wei, P.1
Zhang, J.2
Egan-Hafley, M.3
Liang, S.4
Moore, D.D.5
-
34
-
-
46449119368
-
The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription
-
Yamamoto Y., Negishi M. The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription. Drug Metab. Dispos 2008, 36:1189-1193.
-
(2008)
Drug Metab. Dispos
, vol.36
, pp. 1189-1193
-
-
Yamamoto, Y.1
Negishi, M.2
-
35
-
-
5644295430
-
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobabital in mice
-
Yamamoto Y., Moore R., Goldsworthy T.L., Negishi M., Maronpot R.R. The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobabital in mice. Cancer Res 2004, 64:7197-7200.
-
(2004)
Cancer Res
, vol.64
, pp. 7197-7200
-
-
Yamamoto, Y.1
Moore, R.2
Goldsworthy, T.L.3
Negishi, M.4
Maronpot, R.R.5
|