Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 361-371

  Ye, Qing ^a,b   Shen, Yanhong ^d   Zhou, Yubo ^c   Lv, Dan ^a   Gao, Jianrong ^b   Li, Jia ^c   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c National Center for Drug Screening   (China)

^d ANYANG INSTITUTE OF TECHNOLOGY   (China)

Author keywords

7 Azaindazolyl indolyl maleimides; Cellular activity; Enzymatic activity; GSK 3 inhibitors

Indexed keywords

1 AMINO 3 (1H INDOL 3 YL) 4 (1H PYRAZOLO[3,4 B]PYRIDINE 3 YL) 1H PYRROLE 2,5 DIONE; 1 FORMAMIDO 3 (1H INDOL 3 YL) 4 (1H PYRAZOLO[3,4 B]PYRIDINE 3 YL) 1H PYRROLE 2,5 DIONE; 3 (1 ALLYL 1H INDOL 3 YL) 4 [1 (3 MORPHOLINOPORPYL) 1H PYRAZOLO[3,4 B]PYRIDINE 3 YL] 1 PHENYL 1H PYRROLE 2,5 DIONE; 3 (1 BENZYL 1H INDOL 3 YL) 4 [1 (3 MORPHOLINOPROPYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL] 1H PYRROLE 2,5 DIONE; 3 (1 METHYL 1H INDOL 3 YL) 4 [1 (2 MORPHOLINOETHYL) 1H PYRAZOLO[3,4 B]PYRIDINE 3 YL] 1 PHENYL 1H PYRROLE 2,5 DIONE; 3 (1 METHYL 1H INDOL 3 YL) 4 [1 (2 MORPHOLINOETHYL) 1H PYRAZOLO[3,4 B]PYRIDINE 3 YL] 1H PYRROLE 2,5 DIONE; 3 (1 METHYL 1H INDOL 3 YL) 4 [1 (4 BROMOBUTYL) 1H PYRAZOLO[3,4 B]PYRIDINE 3 YL] 1 PHENYL 1H PYRROLE 2,5 DIONE; 3 (1 METHYL 1H INDOL 3 YL) 4 [1 (4 MORPHOLINOBUTYL) 1H PYRAZOLO[3,4 B]PYRIDINE 3 YL] 1 PHENYL 1H PYRROLE 2,5 DIONE; 3 (1 METHYL 1H INDOL 3 YL) 4 [1 (4 MORPHOLINOBUTYL) 1H PYRAZOLO[3,4 B]PYRIDINE 3 YL] 1H PYRROLE 2,5 DIONE; 3 (1H INDOL 3 YL) 1 ISOBUTYL 4 (1H PYRAZOLO[3,4 B]PYRIDINE 3 YL) 1H PYRROLE 2,5 DIONE; 3 (1H INDOL 3 YL) 1 METHYL 4 (1H PYRAZOLO[3,4 B]PYRIDINE 3 YL) 1H PYRROLE 2,5 DIONE; 3 (1H INDOL 3 YL) 1 PHENYL 4 (1H PYRAZOLO[3,4 B]PYRIDINE 3 YL) 1H PYRROLE 2,5 DIONE; 3 (1H INDOL 3 YL) 4 (1H PYRAZOLO[3,4 B]PYRIDINE 3 YL) 1 THIOUREIDO 1H PYRROLE 2,5 DIONE; 3 (1H INDOL 3 YL) 4 (1H PYRAZOLO[3,4 B]PYRIDINE 3 YL) 1 UREIDO 1H PYRROLE 2,5 DIONE; 3 (1H INDOL 3 YL) 4 (1H PYRAZOLO[3,4 B]PYRIDINE 3 YL) 1H PYRROLE 2,5 DIONE; 3 (1H INDOL 3 YL) 4 (1H PYRAZOLO[3,4 B]PYRIDINE 3 YL)FURAN 2,5 DIONE; 3 (1H INDOL 3 YL) 4 [1 (3 MORPHOLINOPROPYL) 1H PYRAZOLO[3,4 B]PYRIDINE) 3 YL] 1 PHENYL 1H PYRROLE 2,5 DIONE; 3 [1 (3 MORPHOLINOPORPYL) 1H PYRAZOLO[3,4 B]PYRIDINE 3 Y] 1 PHENYL 3 (1 VINYL 1H INDOL 3 YL) 1H PYRROLE 2,5 DIONE; 3 [1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL] 4 CHLORO 1 PHENYL 1H PYRROLE 2,5 DIONE; 3 [1 (TERT BUTYLOXYCARBONYL) 1H INDOL 3 YL] 1 PHENYL 4 [1 (3 MORPHOLINOPROPYL) 1H PYRAZOLO[3,4 B]PYRIDINE 3 YL] 1H PYRROLE 2,5 DIONE; 3 [1 (TERT BUTYLOXYCARBONYL) 1H INDOL 3 YL] 4 (1H PYRAZOLO[3,4 B] PYRIDINE 3 YL) 1H PYRROLE 2,5 DIONE; 7 AZAINDAZOLYL INDOLYLMALEIMIDE DERIVATIVE; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; METHYL 2 [3 (1H INDOL 3 YL) 2,5 DIOXO 4 (1H PYRAZOLO[3,4 B]PYRIDIN 3 YL) 2,5 DIHYDRO 1H PYRROL 1 YL]ACETATE; STAUROSPORINE; TAU PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALKYLATION; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; MELTING POINT; MOLECULAR MODEL; NEUROBLASTOMA; PHARMACOPHORE; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

7-AZAINDAZOLYL-INDOLYL-MALEIMIDES; CELLULAR ACTIVITY; ENZYMATIC ACTIVITY; GSK-3Β INHIBITORS;

AZA COMPOUNDS; BLOTTING, WESTERN; CELL LINE, TUMOR; DRUG DESIGN; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MALEIMIDES; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS;

EID: 84882758063     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.046     Document Type: Article

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