Synthesis and biological evaluation of 3-benzisoxazolyl-4-indolylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3β

Molecules

Volumn 18, Issue 5, 2013, Pages 5498-5516

  Ye, Qing ^a   Li, Meng ^a   Zhou, Yubo ^b   Pang, Tao ^b   Xu, Lei ^b   Cao, Jiayi ^b   Han, Liang ^a   Li, Yujin ^a   Wang, Weisi ^c   Gao, Jianrong ^a   Li, Jia ^b  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^b National Center for Drug Screening   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

3 benzisoxazolyl 4 indolylmaleimides; Biological activity; Docking; GSK 3 ; SAR; Synthesis

Indexed keywords

AMYLOID BETA PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MAPT PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; TAU PROTEIN;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MOLECULAR DOCKING; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; CELL LINE, TUMOR; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MOLECULAR DOCKING SIMULATION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TAU PROTEINS;

EID: 84878285428     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18055498     Document Type: Article

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