Simultaneous inhibition of key growth pathways in melanoma cells and tumor regression by a designed bidentate constrained helical peptide

Biopolymers - Peptide Science Section

Volumn 102, Issue 4, 2014, Pages 344-358

  Dhar, Amlanjyoti ^a   Mallick, Shampa ^a   Ghosh, Piya ^a   Maiti, Atanu ^a   Ahmed, Israr ^a   Bhattacharya, Seemana ^a   Mandal, Tapashi ^a   Manna, Asit ^a   Roy, Koushik ^a   Singh, Sandeep ^b   Nayak, Dipak Kumar ^a   Wilder, Paul T ^c   Markowitz, Joseph ^c   Weber, David ^c   Ghosh, Mrinal K ^a   Chattopadhyay, Samit ^a   Guha, Rajdeep ^a   Konar, Aditya ^a   Bandyopadhyay, Santu ^a   Roy, Siddhartha ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b NATIONAL CENTRE FOR CELL SCIENCE   (India)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Antitumor; Helix; Inhibitor; Peptides; Protein protein interaction

Indexed keywords

CELL DEATH; DERMATOLOGY; DISSOCIATION; DRUG INTERACTIONS; MOLECULES; ONCOLOGY; SIGNALING; TUMORS; CELLS; CYTOLOGY; DRUG PRODUCTS; PEPTIDES;

ANTI-TUMORS; CELL-PENETRATING PEPTIDE; DESIGN AND DEVELOPMENT; DISSOCIATION CONSTANT; HELICAL CONFORMATION; HELIX; INHIBITOR; PROTEIN-PROTEIN INTERACTIONS;

PEPTIDES; PROTEINS;

2 AMINO 2 METHYLPROPIONIC ACID; ANTINEOPLASTIC AGENT; ARG BR AIB TRTK AA PEPTIDE; ARG BR AIB TRTK PEPTIDE; BINDING PROTEIN; CELL PENETRATING PEPTIDE; PROTEIN KINASE B; PROTEIN P53; PROTEIN S100B; STAT3 PROTEIN; UNCLASSIFIED DRUG; PEPTIDE FRAGMENT; PROTEIN BINDING; PROTEIN CAPZ; TRTK-12 PEPTIDE; BRANCHED AMINO ISOBUTYRIC ACID TRTK 15 PEPTIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PROTEIN MDM2; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG EFFICACY; FEMALE; GROWTH INHIBITION; MELANOMA; MELANOMA CELL; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; TUMOR REGRESSION; AMINO ACID SEQUENCE; ANIMAL; CELL SURVIVAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; PHASE CONTRAST MICROSCOPY; PROTEIN SECONDARY STRUCTURE; REMISSION; SIGNAL TRANSDUCTION; TEMPERATURE; TUMOR CELL LINE; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; BINDING AFFINITY; BINDING SITE; CANCER GROWTH; CANCER REGRESSION; CELL MIGRATION; CELL MOTILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CROSS LINKING; DOWN REGULATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REACTIVATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; GROWTH REGULATION; HUMAN CELL; IC50; MELANOMA CELL LINE; MOLECULAR WEIGHT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; PROTON NUCLEAR MAGNETIC RESONANCE; PTOSIS; UPREGULATION;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CAPZ ACTIN CAPPING PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; HUMANS; MELANOMA; MICE; MICROSCOPY, PHASE-CONTRAST; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; REMISSION INDUCTION; SIGNAL TRANSDUCTION; TEMPERATURE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84923102431     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22505     Document Type: Article

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