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Volumn 15, Issue 1, 2014, Pages

A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity

Author keywords

5 fluorouracil; Cardiotoxicity; Pathophysiology; Systematic review

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; CAPECITABINE; ENDOTHELIN 1; FLUOROURACIL; GLUTATHIONE PEROXIDASE; SUPEROXIDE DISMUTASE; ANTINEOPLASTIC ANTIMETABOLITE;

EID: 84923025473     PISSN: None     EISSN: 20506511     Source Type: Journal    
DOI: 10.1186/2050-6511-15-47     Document Type: Article
Times cited : (185)

References (90)
  • 2
    • 84883550748 scopus 로고    scopus 로고
    • Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: A systematic review of incidence, manifestations and predisposing factors
    • Polk A, Vaage-Nilsen M, Vistisen K, Nielsen DL: Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: A systematic review of incidence, manifestations and predisposing factors. Cancer Treat Rev 2013, 39:974-84.
    • (2013) Cancer Treat Rev , vol.39 , pp. 974-984
    • Polk, A.1    Vaage-Nilsen, M.2    Vistisen, K.3    Nielsen, D.L.4
  • 6
    • 22144479717 scopus 로고    scopus 로고
    • The frequency and pattern of cardiotoxicity observed with capecitabine used in conjunction with oxaliplatin in patients treated for advanced colorectal cancer (CRC)
    • Ng M, Cunningham D, Norman AR: The frequency and pattern of cardiotoxicity observed with capecitabine used in conjunction with oxaliplatin in patients treated for advanced colorectal cancer (CRC). Eur J Cancer 2005, 41:1542-1546.
    • (2005) Eur J Cancer , vol.41 , pp. 1542-1546
    • Ng, M.1    Cunningham, D.2    Norman, A.R.3
  • 8
    • 84856757864 scopus 로고    scopus 로고
    • 5-fluorouracil-based therapy induces endovascular injury having potential significance to development of clinically overt cardiotoxicity
    • Jensen SA, Sorensen JB: 5-fluorouracil-based therapy induces endovascular injury having potential significance to development of clinically overt cardiotoxicity. Cancer Chemother Pharmacol 2012, 69:57-64.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 57-64
    • Jensen, S.A.1    Sorensen, J.B.2
  • 9
    • 0034937713 scopus 로고    scopus 로고
    • Antithrombotic treatment in protection against thrombogenic effects of 5-fluorouracil on vascular endothelium: a scanning microscopy evaluation
    • Kinhult S, Albertsson M, Eskilsson J, Cwikiel M: Antithrombotic treatment in protection against thrombogenic effects of 5-fluorouracil on vascular endothelium: a scanning microscopy evaluation. Scanning 2001, 23:1-8.
    • (2001) Scanning , vol.23 , pp. 1-8
    • Kinhult, S.1    Albertsson, M.2    Eskilsson, J.3    Cwikiel, M.4
  • 10
    • 0025060871 scopus 로고
    • Thrombogenicity of intravenous 5-fluorouracil alone or in combination with cisplatin
    • Kuzel T, Esparaz B, Green D, Kies M: Thrombogenicity of intravenous 5-fluorouracil alone or in combination with cisplatin. Cancer 1990, 65:885-889.
    • (1990) Cancer , vol.65 , pp. 885-889
    • Kuzel, T.1    Esparaz, B.2    Green, D.3    Kies, M.4
  • 11
    • 0026665811 scopus 로고
    • Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug
    • Lemaire L, Malet-Martino MC, De Forni M, Martino R, Lasserre B: Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug. Br J Cancer 1992, 66:119-127.
    • (1992) Br J Cancer , vol.66 , pp. 119-127
    • Lemaire, L.1    Malet-Martino, M.C.2    De Forni, M.3    Martino, R.4    Lasserre, B.5
  • 12
    • 0019298802 scopus 로고
    • Cardiotoxic effects of 5-fluorouracil in the guinea pig
    • Matsubara I, Kamiya J, Imai S: Cardiotoxic effects of 5-fluorouracil in the guinea pig. Jpn J Pharmacol 1980, 30:871-879.
    • (1980) Jpn J Pharmacol , vol.30 , pp. 871-879
    • Matsubara, I.1    Kamiya, J.2    Imai, S.3
  • 14
    • 68049122102 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • Moher D, Liberati A, TetzlaffJ, Altman DG: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009, 6:e1000097.
    • (2009) PLoS Med , vol.6
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 15
    • 0029552268 scopus 로고
    • 5-fluorouracil induced cardiotoxicity in albino rats
    • Kumar S, Gupta RK, Samal N: 5-fluorouracil induced cardiotoxicity in albino rats. Mater Med Pol 1995, 27:63-66.
    • (1995) Mater Med Pol , vol.27 , pp. 63-66
    • Kumar, S.1    Gupta, R.K.2    Samal, N.3
  • 20
    • 0026523118 scopus 로고
    • The effects of 5-fluorouracil on contractility and oxygen uptake of the isolated perfused rat heart
    • Millart H, Brabant L, Lorenzato M, Lamiable D, Albert O, Choisy H: The effects of 5-fluorouracil on contractility and oxygen uptake of the isolated perfused rat heart. Anticancer Res 1992, 12:571-576.
    • (1992) Anticancer Res , vol.12 , pp. 571-576
    • Millart, H.1    Brabant, L.2    Lorenzato, M.3    Lamiable, D.4    Albert, O.5    Choisy, H.6
  • 21
    • 0020611278 scopus 로고
    • Effects of ftorafur and 5-fluorouracil on the canine sinoatrial node
    • Satoh H, Hashimoto K: Effects of ftorafur and 5-fluorouracil on the canine sinoatrial node. Jpn J Pharmacol 1983, 33:357-362.
    • (1983) Jpn J Pharmacol , vol.33 , pp. 357-362
    • Satoh, H.1    Hashimoto, K.2
  • 22
    • 0028879734 scopus 로고
    • The influence of 5-fluorouracil on the endothelium in small arteries. An electron microscopic study in rabbits
    • Cwikiel M, Zhang B, Eskilsson J, Wieslander JB, Albertsson M: The influence of 5-fluorouracil on the endothelium in small arteries. An electron microscopic study in rabbits. Scanning Microsc 1995, 9:561-576.
    • (1995) Scanning Microsc , vol.9 , pp. 561-576
    • Cwikiel, M.1    Zhang, B.2    Eskilsson, J.3    Wieslander, J.B.4    Albertsson, M.5
  • 23
    • 0030316464 scopus 로고    scopus 로고
    • The appearance of endothelium in small arteries after treatment with 5-fluorouracil. An electron microscopic study of late effects in rabbits
    • Cwikiel M, Eskilsson J, Wieslander JB, Stjernquist U, Albertsson M: The appearance of endothelium in small arteries after treatment with 5-fluorouracil. An electron microscopic study of late effects in rabbits. Scanning Microsc 1996, 10:805-818.
    • (1996) Scanning Microsc , vol.10 , pp. 805-818
    • Cwikiel, M.1    Eskilsson, J.2    Wieslander, J.B.3    Stjernquist, U.4    Albertsson, M.5
  • 24
    • 0037825850 scopus 로고    scopus 로고
    • Effects of probucol on endothelial damage by 5-fluorouracil
    • Kinhult S, Albertsson M, Eskilsson J, Cwikiel M: Effects of probucol on endothelial damage by 5-fluorouracil. Acta Oncol 2003, 42:304-308.
    • (2003) Acta Oncol , vol.42 , pp. 304-308
    • Kinhult, S.1    Albertsson, M.2    Eskilsson, J.3    Cwikiel, M.4
  • 25
    • 0029810892 scopus 로고    scopus 로고
    • The influence of 5-fluorouracil and methotrexate on vascular endothelium. An experimental study using endothelial cells in the culture
    • Cwikiel M, Eskilsson J, Albertsson M, Stavenow L: The influence of 5-fluorouracil and methotrexate on vascular endothelium. An experimental study using endothelial cells in the culture. Ann Oncol 1996, 7:731-737.
    • (1996) Ann Oncol , vol.7 , pp. 731-737
    • Cwikiel, M.1    Eskilsson, J.2    Albertsson, M.3    Stavenow, L.4
  • 26
    • 0027202039 scopus 로고
    • In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle
    • Mosseri M, Fingert HJ, Varticovski L, Chokshi S, Isner JM: In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle. Cancer Res 1993, 53:3028-3033.
    • (1993) Cancer Res , vol.53 , pp. 3028-3033
    • Mosseri, M.1    Fingert, H.J.2    Varticovski, L.3    Chokshi, S.4    Isner, J.M.5
  • 29
    • 0030726255 scopus 로고    scopus 로고
    • The antineoplastic drug 5-fluorouracil produces echinocytosis and affects blood rheology
    • Baerlocher GM, Beer JH, Owen GR, Meiselman HJ, Reinhart WH: The antineoplastic drug 5-fluorouracil produces echinocytosis and affects blood rheology. Br J Haematol 1997, 99:426-432.
    • (1997) Br J Haematol , vol.99 , pp. 426-432
    • Baerlocher, G.M.1    Beer, J.H.2    Owen, G.R.3    Meiselman, H.J.4    Reinhart, W.H.5
  • 30
    • 28944432545 scopus 로고    scopus 로고
    • Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: membrane structure and functioning
    • Spasojevic I, Maksimovic V, Zakrzewska J, Bacic G: Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: membrane structure and functioning. J Chem Inf Model 2005, 45:1680-1685.
    • (2005) J Chem Inf Model , vol.45 , pp. 1680-1685
    • Spasojevic, I.1    Maksimovic, V.2    Zakrzewska, J.3    Bacic, G.4
  • 31
    • 25144480370 scopus 로고    scopus 로고
    • 31P NMR spectroscopy and polarographic combined study of erythrocytes treated with 5-fluorouracil: cardiotoxicity-related changes in ATP, 2,3-BPG, and O2metabolism
    • Spasojevic I, Zakrzewska J, Bacic GG: 31P NMR spectroscopy and polarographic combined study of erythrocytes treated with 5-fluorouracil: cardiotoxicity-related changes in ATP, 2,3-BPG, and O2metabolism. Ann N Y Acad Sci 2005, 1048:311-320.
    • (2005) Ann N Y Acad Sci , vol.1048 , pp. 311-320
    • Spasojevic, I.1    Zakrzewska, J.2    Bacic, G.G.3
  • 32
    • 58949088362 scopus 로고    scopus 로고
    • Decreased oxygen transfer capacity of erythrocytes as a cause of 5-fluorouracil related ischemia
    • Spasojevic I, Jelic S, Zakrzewska J, Bacic G: Decreased oxygen transfer capacity of erythrocytes as a cause of 5-fluorouracil related ischemia. Molecules 2009, 14:53-67.
    • (2009) Molecules , vol.14 , pp. 53-67
    • Spasojevic, I.1    Jelic, S.2    Zakrzewska, J.3    Bacic, G.4
  • 33
    • 0028966197 scopus 로고
    • Changes of blood viscosity in patients treated with 5-fluorouracil-a link to cardiotoxicity?
    • Cwikiel M, Persson SU, Larsson H, Albertsson M, Eskilsson J: Changes of blood viscosity in patients treated with 5-fluorouracil-a link to cardiotoxicity? Acta Oncol 1995, 34:83-85.
    • (1995) Acta Oncol , vol.34 , pp. 83-85
    • Cwikiel, M.1    Persson, S.U.2    Larsson, H.3    Albertsson, M.4    Eskilsson, J.5
  • 34
    • 79951907915 scopus 로고    scopus 로고
    • Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle
    • Jensen SA, Hasbak P, Mortensen J, Sorensen JB: Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. J Clin Oncol 2010, 28:5280-5286.
    • (2010) J Clin Oncol , vol.28 , pp. 5280-5286
    • Jensen, S.A.1    Hasbak, P.2    Mortensen, J.3    Sorensen, J.B.4
  • 36
    • 0021738428 scopus 로고
    • A model system for measuring comparative toxicities of cardiotoxic drugs for cultured rat heart myocytes, endothelial cells and fibroblasts. II. Doxorubicin, 5-fluorouracil and cyclophosphamide
    • Wenzel DG, Cosma GN: A model system for measuring comparative toxicities of cardiotoxic drugs for cultured rat heart myocytes, endothelial cells and fibroblasts. II. Doxorubicin, 5-fluorouracil and cyclophosphamide. Toxicology 1984, 33:117-128.
    • (1984) Toxicology , vol.33 , pp. 117-128
    • Wenzel, D.G.1    Cosma, G.N.2
  • 37
    • 0021288031 scopus 로고
    • 31P-topical nuclear magnetic resonance (31P-TMR) studies of cardiotoxic effects of 5-fluorouracil (5-FU) and 5'-deoxy-5-fluorouridine (5'-DFUR)
    • Tamatsu H, Nakazawa M, Imai S, Watari H: 31P-topical nuclear magnetic resonance (31P-TMR) studies of cardiotoxic effects of 5-fluorouracil (5-FU) and 5'-deoxy-5-fluorouridine (5'-DFUR). Jpn J Pharmacol 1984, 34:375-379.
    • (1984) Jpn J Pharmacol , vol.34 , pp. 375-379
    • Tamatsu, H.1    Nakazawa, M.2    Imai, S.3    Watari, H.4
  • 39
    • 0345306160 scopus 로고    scopus 로고
    • The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin
    • HasinoffBB, Patel D, Wu X: The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin. Free Radic Biol Med 2003, 35:1469-1479.
    • (2003) Free Radic Biol Med , vol.35 , pp. 1469-1479
    • Hasinoff, B.B.1    Patel, D.2    Wu, X.3
  • 40
    • 0027489682 scopus 로고
    • The role of iron and iron chelators in anthracycline cardiotoxicity
    • Hershko C, Link G, Tzahor M, Pinson A: The role of iron and iron chelators in anthracycline cardiotoxicity. Leuk Lymphoma 1993, 11:207-214.
    • (1993) Leuk Lymphoma , vol.11 , pp. 207-214
    • Hershko, C.1    Link, G.2    Tzahor, M.3    Pinson, A.4
  • 41
    • 0034608083 scopus 로고    scopus 로고
    • Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases
    • Kang YJ, Zhou ZX, Wang GW, Buridi A, Klein JB: Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases. J Biol Chem 2000, 275:13690-13698.
    • (2000) J Biol Chem , vol.275 , pp. 13690-13698
    • Kang, Y.J.1    Zhou, Z.X.2    Wang, G.W.3    Buridi, A.4    Klein, J.B.5
  • 42
    • 24344438247 scopus 로고    scopus 로고
    • Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase
    • Kim DS, Kim HR, Woo ER, Hong ST, Chae HJ, Chae SW: Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase. Biochem Pharmacol 2005, 70:1066-1078.
    • (2005) Biochem Pharmacol , vol.70 , pp. 1066-1078
    • Kim, D.S.1    Kim, H.R.2    Woo, E.R.3    Hong, S.T.4    Chae, H.J.5    Chae, S.W.6
  • 43
    • 0036784362 scopus 로고    scopus 로고
    • Unexpected anthracycline-mediated alterations in iron-regulatory protein-RNA-binding activity: the iron and copper complexes of anthracyclines decrease RNA-binding activity
    • Kwok JC, Richardson DR: Unexpected anthracycline-mediated alterations in iron-regulatory protein-RNA-binding activity: the iron and copper complexes of anthracyclines decrease RNA-binding activity. Mol Pharmacol 2002, 62:888-900.
    • (2002) Mol Pharmacol , vol.62 , pp. 888-900
    • Kwok, J.C.1    Richardson, D.R.2
  • 44
    • 0035576817 scopus 로고    scopus 로고
    • Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy
    • Minotti G, Ronchi R, Salvatorelli E, Menna P, Cairo G: Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy. Cancer Res 2001, 61:8422-8428.
    • (2001) Cancer Res , vol.61 , pp. 8422-8428
    • Minotti, G.1    Ronchi, R.2    Salvatorelli, E.3    Menna, P.4    Cairo, G.5
  • 45
    • 0035201297 scopus 로고    scopus 로고
    • Anthracycline-induced cardiac injury using a cardiac cell line: potential for gene therapy studies
    • L'Ecuyer T, Horenstein MS, Thomas R, Vander HR: Anthracycline-induced cardiac injury using a cardiac cell line: potential for gene therapy studies. Mol Genet Metab 2001, 74:370-379.
    • (2001) Mol Genet Metab , vol.74 , pp. 370-379
    • L'Ecuyer, T.1    Horenstein, M.S.2    Thomas, R.3    Vander, H.R.4
  • 46
    • 0033014821 scopus 로고    scopus 로고
    • Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane
    • Sawyer DB, Fukazawa R, Arstall MA, Kelly RA: Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. Circ Res 1999, 84:257-265.
    • (1999) Circ Res , vol.84 , pp. 257-265
    • Sawyer, D.B.1    Fukazawa, R.2    Arstall, M.A.3    Kelly, R.A.4
  • 47
    • 84871802129 scopus 로고    scopus 로고
    • Takotsubo syndrome: an underdiagnosed complication of 5-fluorouracil mimicking acute myocardial infarction
    • Ozturk MA, Ozveren O, Cinar V, Erdik B, Oyan B: Takotsubo syndrome: an underdiagnosed complication of 5-fluorouracil mimicking acute myocardial infarction. Blood Coagul Fibrinolysis 2013, 24:90-94.
    • (2013) Blood Coagul Fibrinolysis , vol.24 , pp. 90-94
    • Ozturk, M.A.1    Ozveren, O.2    Cinar, V.3    Erdik, B.4    Oyan, B.5
  • 49
  • 50
    • 80052581636 scopus 로고    scopus 로고
    • Ventricular fibrillation as a likely consequence of capecitabine-induced coronary vasospasm
    • Shah NR, Shah A, Rather A: Ventricular fibrillation as a likely consequence of capecitabine-induced coronary vasospasm. J Oncol Pharm Pract 2012, 18:132-135.
    • (2012) J Oncol Pharm Pract , vol.18 , pp. 132-135
    • Shah, N.R.1    Shah, A.2    Rather, A.3
  • 52
    • 81755187740 scopus 로고    scopus 로고
    • Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis
    • Calik AN, Celiker E, Velibey Y, Cagdas M, Guzelburc O: Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis. Am J Emerg Med 2012, 30:257-3.
    • (2012) Am J Emerg Med , vol.30 , pp. 257-263
    • Calik, A.N.1    Celiker, E.2    Velibey, Y.3    Cagdas, M.4    Guzelburc, O.5
  • 53
    • 78049352774 scopus 로고    scopus 로고
    • Two cases of coronary vasospasm induced by 5-fluorouracil
    • Atar A, Korkmaz ME, Ozin B: Two cases of coronary vasospasm induced by 5-fluorouracil. Anadolu Kardiyol Derg 2010, 10:461-462.
    • (2010) Anadolu Kardiyol Derg , vol.10 , pp. 461-462
    • Atar, A.1    Korkmaz, M.E.2    Ozin, B.3
  • 54
    • 84856173818 scopus 로고    scopus 로고
    • Angina induced by 5-fluorouracil infusion in a patient with normal coronaries
    • Tajik R, Saadat H, Taherkhani M, Movahed MR: Angina induced by 5-fluorouracil infusion in a patient with normal coronaries. Am Heart Hosp J 2010, 8:E111-E112.
    • (2010) Am Heart Hosp J , vol.8 , pp. E111-E112
    • Tajik, R.1    Saadat, H.2    Taherkhani, M.3    Movahed, M.R.4
  • 55
    • 70349293928 scopus 로고    scopus 로고
    • Acute chest pain in a patient treated with capecitabine
    • Camaro C, Danse PW, Bosker HA: Acute chest pain in a patient treated with capecitabine. Neth Heart J 2009, 17:288-291.
    • (2009) Neth Heart J , vol.17 , pp. 288-291
    • Camaro, C.1    Danse, P.W.2    Bosker, H.A.3
  • 56
    • 67649556029 scopus 로고    scopus 로고
    • 5 flourouracil-induced apical ballooning syndrome: a case report
    • Gianni M, Dentali F, Lonn E: 5 flourouracil-induced apical ballooning syndrome: a case report. Blood Coagul Fibrinolysis 2009, 20:306-308.
    • (2009) Blood Coagul Fibrinolysis , vol.20 , pp. 306-308
    • Gianni, M.1    Dentali, F.2    Lonn, E.3
  • 58
    • 55349114018 scopus 로고    scopus 로고
    • Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction
    • Scott PA, Ferchow L, Hobson A, Curzen NP: Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction. Emerg Med J 2008, 25:699-700.
    • (2008) Emerg Med J , vol.25 , pp. 699-700
    • Scott, P.A.1    Ferchow, L.2    Hobson, A.3    Curzen, N.P.4
  • 60
    • 33645796920 scopus 로고    scopus 로고
    • Acute coronary syndrome induced by oral capecitabine
    • Cardinale D, Colombo A, Colombo N: Acute coronary syndrome induced by oral capecitabine. Can J Cardiol 2006, 22:251-253.
    • (2006) Can J Cardiol , vol.22 , pp. 251-253
    • Cardinale, D.1    Colombo, A.2    Colombo, N.3
  • 61
    • 2142813823 scopus 로고    scopus 로고
    • Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases
    • Mafrici A, Alberti A, Corrada E, Ferrari S, Marenna B: Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases. Ital Heart J 2003, 4:895-899.
    • (2003) Ital Heart J , vol.4 , pp. 895-899
    • Mafrici, A.1    Alberti, A.2    Corrada, E.3    Ferrari, S.4    Marenna, B.5
  • 62
    • 3042640715 scopus 로고    scopus 로고
    • 5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
    • McGlinchey PG, Webb ST, Campbell NP: 5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report. BMC Cardiovasc Disord 2001, 1:3.
    • (2001) BMC Cardiovasc Disord , vol.1 , pp. 3
    • McGlinchey, P.G.1    Webb, S.T.2    Campbell, N.P.3
  • 65
    • 0029738919 scopus 로고    scopus 로고
    • Fibrin and fibrinogen degradation products in plasma of patients with colorectal adenocarcinoma
    • Okholm M, Iversen LH, Thorlacius-Ussing O, Ejlersen E, Boesby S: Fibrin and fibrinogen degradation products in plasma of patients with colorectal adenocarcinoma. Dis Colon Rectum 1996, 39:1102-1106.
    • (1996) Dis Colon Rectum , vol.39 , pp. 1102-1106
    • Okholm, M.1    Iversen, L.H.2    Thorlacius-Ussing, O.3    Ejlersen, E.4    Boesby, S.5
  • 66
    • 0034792951 scopus 로고    scopus 로고
    • High preoperative plasma D-dimer level is associated with advanced tumor stage and short survival after curative resection in patients with colorectal cancer
    • Oya M, Akiyama Y, Okuyama T, Ishikawa H: High preoperative plasma D-dimer level is associated with advanced tumor stage and short survival after curative resection in patients with colorectal cancer. Jpn J Clin Oncol 2001, 31:388-394.
    • (2001) Jpn J Clin Oncol , vol.31 , pp. 388-394
    • Oya, M.1    Akiyama, Y.2    Okuyama, T.3    Ishikawa, H.4
  • 67
    • 3042529038 scopus 로고    scopus 로고
    • Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma
    • Blackwell K, Hurwitz H, Lieberman G, Novotny W, Snyder S, Dewhirst M, Greenberg C: Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma. Cancer 2004, 101:77-82.
    • (2004) Cancer , vol.101 , pp. 77-82
    • Blackwell, K.1    Hurwitz, H.2    Lieberman, G.3    Novotny, W.4    Snyder, S.5    Dewhirst, M.6    Greenberg, C.7
  • 68
    • 0029806415 scopus 로고    scopus 로고
    • Pre-and postoperative state of coagulation and fibrinolysis in plasma of patients with benign and malignant colorectal disease-a preliminary study
    • Iversen LH, Okholm M, Thorlacius-Ussing O: Pre-and postoperative state of coagulation and fibrinolysis in plasma of patients with benign and malignant colorectal disease-a preliminary study. Thromb Haemost 1996, 76:523-528.
    • (1996) Thromb Haemost , vol.76 , pp. 523-528
    • Iversen, L.H.1    Okholm, M.2    Thorlacius-Ussing, O.3
  • 72
    • 17444368101 scopus 로고    scopus 로고
    • Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma
    • Wang WS, Lin JK, Lin TC, Chiou TJ, Liu JH, Yen CC, Chen PM: Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma. World J Gastroenterol 2005, 11:2166-2170.
    • (2005) World J Gastroenterol , vol.11 , pp. 2166-2170
    • Wang, W.S.1    Lin, J.K.2    Lin, T.C.3    Chiou, T.J.4    Liu, J.H.5    Yen, C.C.6    Chen, P.M.7
  • 73
    • 9444268893 scopus 로고
    • Cardiac toxicity of 5-fluorouracil in rabbits
    • Ref Type: Abstract.
    • Suzuki T, Nakanishi H, Hayashi A: Cardiac toxicity of 5-fluorouracil in rabbits. Jpn J Pharmacol 1977, 27 s:137. Ref Type: Abstract.
    • (1977) Jpn J Pharmacol , vol.27s , pp. 137
    • Suzuki, T.1    Nakanishi, H.2    Hayashi, A.3
  • 74
    • 84873836880 scopus 로고    scopus 로고
    • Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection
    • Sterba M, Popelova O, Vavrova A, Jirkovsky E, Kovarikova P, Gersl V, Simunek T: Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal 2013, 18:899-929.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 899-929
    • Sterba, M.1    Popelova, O.2    Vavrova, A.3    Jirkovsky, E.4    Kovarikova, P.5    Gersl, V.6    Simunek, T.7
  • 75
    • 0034648298 scopus 로고    scopus 로고
    • The Haber-Weiss reaction and mechanisms of toxicity
    • Kehrer JP: The Haber-Weiss reaction and mechanisms of toxicity. Toxicology 2000, 149:43-50.
    • (2000) Toxicology , vol.149 , pp. 43-50
    • Kehrer, J.P.1
  • 76
    • 0030838509 scopus 로고    scopus 로고
    • Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors
    • Nielsen F, Mikkelsen BB, Nielsen JB, Andersen HR, Grandjean P: Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clin Chem 1997, 43:1209-1214.
    • (1997) Clin Chem , vol.43 , pp. 1209-1214
    • Nielsen, F.1    Mikkelsen, B.B.2    Nielsen, J.B.3    Andersen, H.R.4    Grandjean, P.5
  • 77
    • 0034126304 scopus 로고    scopus 로고
    • Effects of probucol on changes of antioxidant enzymes in adriamycin-induced cardiomyopathy in rats
    • Li T, Danelisen I, Bello-Klein A, Singal PK: Effects of probucol on changes of antioxidant enzymes in adriamycin-induced cardiomyopathy in rats. Cardiovasc Res 2000, 46:523-530.
    • (2000) Cardiovasc Res , vol.46 , pp. 523-530
    • Li, T.1    Danelisen, I.2    Bello-Klein, A.3    Singal, P.K.4
  • 78
    • 0028275840 scopus 로고
    • Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats
    • Siveski-Iliskovic N, Kaul N, Singal PK: Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation 1994, 89:2829-2835.
    • (1994) Circulation , vol.89 , pp. 2829-2835
    • Siveski-Iliskovic, N.1    Kaul, N.2    Singal, P.K.3
  • 79
    • 0029584562 scopus 로고
    • Probucol improves antioxidant activity and modulates development of diabetic cardiomyopathy
    • Kaul N, Siveski-Iliskovic N, Thomas TP, Hill M, Khaper N, Singal PK: Probucol improves antioxidant activity and modulates development of diabetic cardiomyopathy. Nutrition 1995, 11:551-554.
    • (1995) Nutrition , vol.11 , pp. 551-554
    • Kaul, N.1    Siveski-Iliskovic, N.2    Thomas, T.P.3    Hill, M.4    Khaper, N.5    Singal, P.K.6
  • 83
    • 77949659465 scopus 로고    scopus 로고
    • The endothelial cell in health and disease: its function, dysfunction, measurement and therapy
    • Schwartz BG, Economides C, Mayeda GS, Burstein S, Kloner RA: The endothelial cell in health and disease: its function, dysfunction, measurement and therapy. Int J Impot Res 2010, 22:77-90.
    • (2010) Int J Impot Res , vol.22 , pp. 77-90
    • Schwartz, B.G.1    Economides, C.2    Mayeda, G.S.3    Burstein, S.4    Kloner, R.A.5
  • 84
    • 0023052241 scopus 로고
    • Studies and perspectives of protein kinase C
    • Nishizuka Y: Studies and perspectives of protein kinase C. Science 1986, 233:305-312.
    • (1986) Science , vol.233 , pp. 305-312
    • Nishizuka, Y.1
  • 85
    • 0029116310 scopus 로고
    • Endothelins
    • Levin ER: Endothelins. N Engl J Med 1995, 333:356-363.
    • (1995) N Engl J Med , vol.333 , pp. 356-363
    • Levin, E.R.1
  • 86
    • 77955659816 scopus 로고    scopus 로고
    • Endothelin-biology and disease
    • Khimji AK, Rockey DC: Endothelin-biology and disease. Cell Signal 2010, 22:1615-1625.
    • (2010) Cell Signal , vol.22 , pp. 1615-1625
    • Khimji, A.K.1    Rockey, D.C.2
  • 87
    • 0035169004 scopus 로고    scopus 로고
    • The physiological role of endogenous endothelin in the regulation of human coronary vasomotor tone
    • MacCarthy PA, Pegge NC, Prendergast BD, Shah AM, Groves PH: The physiological role of endogenous endothelin in the regulation of human coronary vasomotor tone. J Am Coll Cardiol 2001, 37:137-143.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 137-143
    • MacCarthy, P.A.1    Pegge, N.C.2    Prendergast, B.D.3    Shah, A.M.4    Groves, P.H.5
  • 89
    • 6844251612 scopus 로고    scopus 로고
    • The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate
    • Arellano M, Malet-Martino M, Martino R, Gires P: The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate. Br J Cancer 1998, 77:79-86.
    • (1998) Br J Cancer , vol.77 , pp. 79-86
    • Arellano, M.1    Malet-Martino, M.2    Martino, R.3    Gires, P.4
  • 90


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