The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate

British Journal of Cancer

Volumn 77, Issue 1, 1998, Pages 79-86

  Arellano, M ^a   Malet Martino, M ^a   Martino, R ^a   Gires, P ^b  

^a Université Paul Sabatier   (France)

^b SANOFI   (France)

Author keywords

5 fluorouracil; 19F nuclear magnetic resonance; Fluoroacetate; Isolated perfused rat liver; Metabolism; Rat urine; fluoro alanine; fluoro hydroxypropionic acid

Indexed keywords

ALPHA FLUORO BETA ALANINE; ANTINEOPLASTIC AGENT; DRUG METABOLITE; FLUOROACETIC ACID; FLUOROURACIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG METABOLISM; DRUG TRANSFORMATION; ISOLATED LIVER; LIVER METABOLISM; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; URINE;

EID: 6844251612     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.12     Document Type: Article

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