5-Fluorouracil-based therapy induces endovascular injury having potential significance to development of clinically overt cardiotoxicity

Cancer Chemotherapy and Pharmacology

Volumn 69, Issue 1, 2012, Pages 57-64

  Jensen, Søren Astrup ^a   Sørensen, Jens Benn ^a  

^a University of Copenhagen   (Denmark)

Author keywords

Cardiotoxicity; Coagulation activity; Colorectal neoplasms; Endothelial dysfunction; Fibrin D dimer; Fluorouracil; Glomerular damage; Plasma von Willebrand factor; Urine albumin

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; FIBRIN; FLUOROURACIL; FOLINIC ACID; GLYCERYL TRINITRATE; OXALIPLATIN; PROTHROMBIN; VON WILLEBRAND FACTOR;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CARDIOTOXICITY; CARDIOVASCULAR RISK; CLINICAL ASSESSMENT; COLORECTAL CANCER; CREATININE URINE LEVEL; DEEP VEIN THROMBOSIS; DRUG DOSE REDUCTION; DRUG EFFICACY; FEMALE; HEART FAILURE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SIDE EFFECT; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOLOGICAL MARKERS; CHEMOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; ENDOTHELIUM, VASCULAR; FEMALE; FLUOROURACIL; HUMANS; LEUCOVORIN; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; ORGANOPLATINUM COMPOUNDS; PROSPECTIVE STUDIES; RISK FACTORS; VON WILLEBRAND FACTOR;

EID: 84856757864     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-011-1669-x     Document Type: Article

References (48)

1. SA Jensen JB Sorensen 2006 Risk factors and prevention of cardiotoxicity induced by 5-fluorouracil or capecitabine Cancer Chemother Pharmacol 58 487 493 16418875 10.1007/s00280-005-0178-1 1:CAS:528:DC%2BD28XmsVShtL4%3D (Pubitemid 43999797)
2. A Wacker C Lersch U Scherpinski L Reindl M Seyfarth 2003 High incidence of angina pectoris in patients treated with 5-fluorouracil. A planned surveillance study with 102 patients Oncology 65 108 112 12931015 10.1159/000072334 1:CAS:528:DC%2BD3sXmsFaqurY%3D (Pubitemid 37025969)
3. N Tsavaris C Kosmas M Vadiaka M Efremidis A Zinelis D Beldecos D Sakelariou C Koufos G Stamatelos 2002 Cardiotoxicity following different doses and schedules of 5-fluorouracil administration for malignancy-a survey of 427 patients Med Sci Monit 8 I51 I57
4. C Schober E Papageorgiou A Harstrick C Bokemeyer A Mugge M Stahl H Wilke H Poliwoda W Hiddemann CH Kohne-Wompner 1993 Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer Cancer 72 2242 2247 8374883 10.1002/1097-0142(19931001)72:7<2242::AID- CNCR2820720730>3.0.CO;2-E 1:STN:280:DyaK3szos1Kmug%3D%3D (Pubitemid 23280155)
5. NC Robben AW Pippas JO Moore 1993 The syndrome of 5-fluorouracil cardiotoxicity. An elusive cardiopathy Cancer 71 493 509 8422644 10.1002/1097-0142(19930115)71:2<493::AID-CNCR2820710235>3.0.CO;2-C 1:STN:280:DyaK3s7jslWquw%3D%3D (Pubitemid 23021241)
6. M De Forni MC Malet-Martino P Jaillais RE Shubinski JM Bachaud L Lemaire P Canal C Chevreau D Carrie P Soulie 1992 Cardiotoxicity of high-dose continuous infusion fluorouracil: a prospective clinical study J Clin Oncol 10 1795 1801 1403060 (Pubitemid 23059959)
7. M Mosseri HJ Fingert L Varticovski S Chokshi JM Isner 1993 In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle Cancer Res 53 3028 3033 8391384 1:CAS:528:DyaK3sXltVymtLo%3D (Pubitemid 23210307)
8. C Porta M Moroni S Ferrari G Nastasi 1998 Endothelin-1 and 5-fluorouracil-induced cardiotoxicity Neoplasma 45 81 82 9687887 1:CAS:528:DyaK1cXjsFKisro%3D (Pubitemid 28247448)
9. CH Kohne P Thuss-Patience M Friedrich PT Daniel A Kretzschmar T Benter B Bauer R Dietz B Dorken 1998 Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity Br J Cancer 77 973 977 9528843 10.1038/bjc.1998.160 1:CAS:528:DyaK1cXisVSqsbo%3D (Pubitemid 28101788)
10. T Kuzel B Esparaz D Green M Kies 1990 Thrombogenicity of intravenous 5-fluorouracil alone or in combination with cisplatin Cancer 65 885 889 2297659 10.1002/1097-0142(19900215)65:4<885::AID-CNCR2820650410>3.0.CO;2-H 1:STN:280:DyaK3c7isVWmsg%3D%3D (Pubitemid 20063490)
11. I Matsubara J Kamiya S Imai 1980 Cardiotoxic effects of 5-fluorouracil in the guinea pig Jpn J Pharmacol 30 871 879 7241861 10.1254/jjp.30.871 1:CAS:528:DyaL3MXlvVegsg%3D%3D (Pubitemid 11162895)
12. L Lemaire MC Malet-Martino S Longo R Martino M De Forni M Carton 1991 Fluoroacetaldehyde as cardiotoxic impurity in fluorouracil (Roche) Lancet 337 560 1671927 10.1016/0140-6736(91)91353-V 1:STN:280:DyaK3M7lsFGmsQ%3D%3D
13. S Kinhult M Albertsson J Eskilsson M Cwikiel 2001 Antithrombotic treatment in protection against thrombogenic effects of 5-fluorouracil on vascular endothelium: a scanning microscopy evaluation Scanning 23 1 8 11272331 10.1002/sca.4950230101 1:CAS:528:DC%2BD3MXhs1Smsrg%3D (Pubitemid 32655510)
14. M Cwikiel J Eskilsson JB Wieslander U Stjernquist M Albertsson 1996 The appearance of endothelium in small arteries after treatment with 5-fluorouracil. An electron microscopic study of late effects in rabbits Scanning Microsc 10 805 818 9813641 1:CAS:528:DyaK1cXnt1Whu7s%3D
15. M Cwikiel B Zhang J Eskilsson JB Wieslander M Albertsson 1995 The influence of 5-fluorouracil on the endothelium in small arteries. An electron microscopic study in rabbits Scanning Microsc 9 561 576 8714749 1:CAS:528:DyaK28XisFGjtg%3D%3D
16. AY Chow C Chin G Dahl DN Rosenthal 2006 Anthracyclines cause endothelial injury in pediatric cancer patients: a pilot study J Clin Oncol 24 925 928 16484703 10.1200/JCO.2005.03.5956 1:CAS:528:DC%2BD28Xitl2qt78%3D (Pubitemid 46638846)
17. R Hayward R Ruangthai CM Schneider RM Hyslop R Strange KC Westerlind 2004 Training enhances vascular relaxation after chemotherapy-induced vasoconstriction Med Sci Sports Exerc 36 428 434 15076784 10.1249/01.MSS. 0000117130.91142.38 1:CAS:528:DC%2BD2cXjtFGjtrY%3D (Pubitemid 38298694)
18. M Sudoh Y Kishimoto A Marumoto M Inoue A Sano N Miura Y Horie J Hasegawa K Ryoke 2004 A new animal model of continuous catheterization for investigating mechanisms of arteritis associated with chemotherapy Life Sci 74 3025 3032 15051425 10.1016/j.lfs.2003.11.017 1:CAS:528:DC%2BD2cXisF2msb4%3D (Pubitemid 38402298)
19. CJ Allegra G Yothers MJ O'Connell S Sharif LH Colangelo SH Lopa NJ Petrelli RM Goldberg JN Atkins TE Seay L Fehrenbacher S O'Reilly L Chu CA Azar N Wolmark 2009 Initial safety report of NSABP C-08: a randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer J Clin Oncol 27 3385 3390 19414665 10.1200/JCO.2009.21.9220 1:CAS:528:DC%2BD1MXpvFejtL4%3D
20. E Van Cutsem F Rivera S Berry A Kretzschmar M Michael M DiBartolomeo MA Mazier JL Canon V Georgoulias M Peeters J Bridgewater D Cunningham 2009 Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study Ann Oncol 20 1842 1847 19406901 10.1093/annonc/mdp233
21. F Kabbinavar HI Hurwitz L Fehrenbacher NJ Meropol WF Novotny G Lieberman S Griffing E Bergsland 2003 Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer J Clin Oncol 21 60 65 12506171 10.1200/JCO.2003.10. 066 1:CAS:528:DC%2BD2cXpsVWru7Y%3D
22. JI Zwicker HA Liebman D Neuberg R Lacroix KA Bauer BC Furie B Furie 2009 Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy Clin Cancer Res 15 6830 6840 19861441 10.1158/1078-0432.CCR-09-0371 1:CAS:528:DC%2BD1MXhtl2ktLzJ
23. Bazo IG, Gonzales VC, Gutierrez AA, Rodriguez JR, Fernandez JAP, Gomez JC, Lizoain JLH, Lopez JG (2005) Impact of surgery and chemotherapy on von Willebrand factor and vascular endothelial growth factor levels in colorectal cancer. Clin Transl Oncol 7:150-155
24. EM van Duijnhoven FA Lustermans JW van Wersch 1993 Evaluation of the coagulation/fibrinolysis balance in patients with colorectal cancer Haemostasis 23 168 172 8276320 (Pubitemid 23308551)
25. Mochizuki S, Yoshino T, Kojima T, Fuse N, Ikematsu H, Minashi K, Yano T, Tahara M, Kaneko K, Doi T, Koike K, Ohtsu A (2010) Therapeutic significance of a D-dimer cut-off level of >3 {micro}g/ml in colorectal cancer patients treated with standard chemotherapy plus bevacizumab. Jpn J Clin Oncol 40:933-937
26. G Xu YL Zhang W Huang 2004 Relationship between plasma D-dimer levels and clinicopathologic parameters in resectable colorectal cancer patients World J Gastroenterol 10 922 923 15040048 1:CAS:528:DC%2BD2cXjtl2hu7w%3D (Pubitemid 38418377)
27. M Oya Y Akiyama T Okuyama H Ishikawa 2001 High preoperative plasma D-dimer level is associated with advanced tumor stage and short survival after curative resection in patients with colorectal cancer Jpn J Clin Oncol 31 388 394 11574632 10.1093/jjco/hye075 1:STN:280:DC%2BD3MrivVGhsg%3D%3D
28. K Blackwell H Hurwitz G Lieberman W Novotny S Snyder M Dewhirst C Greenberg 2004 Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma Cancer 101 77 82 15221991 10.1002/cncr.20336 1:CAS:528:DC%2BD2cXlvFCnu7s%3D (Pubitemid 38812425)
29. DC Damin MA Rosito P Gus I Roisemberg E Bandinelli G Schwartsmann 2002 Von Willebrand factor in colorectal cancer Int J Colorectal Dis 17 42 45 12018453 10.1007/s003840100345 (Pubitemid 41398990)
30. WS Wang JK Lin TC Lin TJ Chiou JH Liu CC Yen PM Chen 2005 Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma World J Gastroenterol 11 2166 2170 15810086 1:CAS:528:DC%2BD2MXktlWrtrg%3D
31. SA Jensen P Hasbak J Mortensen JB Sorensen 2010 Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle J Clin Oncol 28 5280 5286 10.1200/JCO.2009.27.3953 21079148 10.1200/JCO.2009.27.3953 1:CAS:528: DC%2BC3MXhtVKqsL4%3D
32. Guidelines Subcommittee 1999 1999 World Health Organization-international society of hypertension guidelines for the management of hypertension J Hypertens 17 151 183
33. American Diabetes Association (2007) Diagnosis and classification of diabetes mellitus Diabetes Care 30(Suppl 1):S42-S47
34. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) JAMA 285:2486-2497
35. JJ Dignam BN Polite G Yothers P Raich L Colangelo MJ O'Connell N Wolmark 2006 Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer J Natl Cancer Inst 98 1647 1654 17105987 10.1093/jnci/djj442 (Pubitemid 44811647)
36. JS Jensen P Clausen K Borch-Johnsen G Jensen B Feldt-Rasmussen 1997 Detecting microalbuminuria by urinary albumin/creatinine concentration ratio Nephrol Dial Transplant 12 Suppl 2 6 9 9269691 (Pubitemid 27331296)
37. H Millart L Brabant M Lorenzato D Lamiable O Albert H Choisy 1992 The effects of 5-fluorouracil on contractility and oxygen uptake of the isolated perfused rat heart Anticancer Res 12 571 576 1580574 1:CAS:528: DyaK38Xks1ansb8%3D
38. J Feliu MJ Safont A Salud F Losa C Garcia-Giron C Bosch P Escudero R Lopez C Madronal M Bolanos M Gil A Llombart J Castro-Carpeno M Gonzalez-Baron 2010 Capecitabine and bevacizumab as first-line treatment in elderly patients with metastatic colorectal cancer Br J Cancer 102 1468 1473 20424611 10.1038/sj.bjc.6605663 1:CAS:528:DC%2BC3cXlvVOgsb0%3D
39. MT Stender JB Frokjaer TB Larsen S Lundbye-Christensen O Thorlacius-Ussing 2009 Preoperative plasma D-dimer is a predictor of postoperative deep venous thrombosis in colorectal cancer patients: a clinical, prospective cohort study with one-year follow-up Dis Colon Rectum 52 446 451 19333044 10.1007/DCR.0b013e318197e2b2
40. JA Heit MD Silverstein DN Mohr TM Petterson WM O'Fallon LJ Melton III 2000 Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study Arch Intern Med 160 809 815 10737280 10.1001/archinte.160.6.809 1:STN:280:DC%2BD3c7pvFGnsw%3D%3D (Pubitemid 30165241)
41. LL Swystun LY Shin S Beaudin PC Liaw 2009 Chemotherapeutic agents doxorubicin and epirubicin induce a procoagulant phenotype on endothelial cells and blood monocytes J Thromb Haemost 7 619 626 19187077 10.1111/j.1538-7836. 2009.03300.x 1:CAS:528:DC%2BD1MXltFyntro%3D
42. SG Gordon BA Cross 1981 A factor X-activating cysteine protease from malignant tissue J Clin Invest 67 1665 1671 7016920 10.1172/JCI110203 1:CAS:528:DyaL3MXkslGqtL4%3D (Pubitemid 11127557)
43. A Varki 2007 Trousseau's syndrome: multiple definitions and multiple mechanisms Blood 110 1723 1729 17496204 10.1182/blood-2006-10-053736 1:CAS:528:DC%2BD2sXhtVGjtLfJ (Pubitemid 47443881)
44. G Hron M Kollars H Weber V Sagaster P Quehenberger S Eichinger PA Kyrle A Weltermann 2007 Tissue factor-positive microparticles: cellular origin and association with coagulation activation in patients with colorectal cancer Thromb Haemost 97 119 123 17200778 1:CAS:528:DC%2BD2sXhvVOjsLg%3D (Pubitemid 46242392)
45. M Ozturk N Sengul M Dagli A Kosar N Bavbek 2003 Global fibrinolytic capacity in colorectal cancer: a new clue to occult fibrinolysis Clin Appl Thromb Hemost 9 151 154 12812385 10.1177/107602960300900210 (Pubitemid 36665983)
46. C Kockar O Kockar M Ozturk M Dagli N Bavbek A Kosar 2005 Global fibrinolytic capacity increased exponentially in metastatic colorectal cancer Clin Appl Thromb Hemost 11 227 230 15821831 10.1177/107602960501100214 1:CAS:528:DC%2BD2MXktlWqtrg%3D (Pubitemid 40548008)
47. J Frielingsdorf P Kaufmann T Suter R Hug OM Hess 1998 Percutaneous transluminal coronary angioplasty reverses vasoconstriction of stenotic coronary arteries in hypertensive patients Circulation 98 1192 1197 9743510 1:STN:280:DyaK1cvhs1Wntw%3D%3D (Pubitemid 28436169)
48. D Lechner M Kollars A Gleiss PA Kyrle A Weltermann 2007 Chemotherapy-induced thrombin generation via procoagulant endothelial microparticles is independent of tissue factor activity J Thromb Haemost 5 2445 2452 17922809 10.1111/j.1538-7836.2007.02788.x 1:CAS:528:DC%2BD1cXivFGh (Pubitemid 350154355)