Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 308, Issue 4, 2015, Pages L368-L377

  Kim, Francis Y ^a   Barnes, Elizabeth A ^a   Ying, Lihua ^a   Chen, Chihhsin ^a   Lee, Lori ^a   Alvira, Cristina M ^a   Cornfield, David N ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Pulmonary hypertension; Smooth muscle cells

Indexed keywords

CRE RECOMBINASE; ENDOTHELIN 1; ACTIN BINDING PROTEIN; MUSCLE PROTEIN; TAGLN PROTEIN, MOUSE; TRANSGELIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BLOOD VESSEL REACTIVITY; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; TRANSGENIC MOUSE; VASCULAR REMODELING; ANIMAL; ANOXIA; BIOSYNTHESIS; CELL CULTURE; CELL MOTION; CHRONIC DISEASE; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANOXIA; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHRONIC DISEASE; ENDOTHELIAL CELLS; ENDOTHELIN-1; GENE EXPRESSION REGULATION; GENE SILENCING; HUMANS; MICE; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; VASCULAR REMODELING;

EID: 84922991819     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00253.2014     Document Type: Article

References (41)

1. Benza RL, Miller DP, Gomberg-Maitland M, Frantz RP, Foreman AJ, Coffey CS, Frost A, Barst RJ, Badesch DB, Elliott CG, Liou TG, McGoon MD. Predicting survival in pulmonary arterial hypertension: Insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation 122: 164-172, 2010.
2. Bonvallet ST, Zamora MR, Hasunuma K, Sato K, Hanasato N, Anderson D, Sato K, Stelzner TJ. BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol 266: H1327-H1331, 1994.
3. Cassin S, Dawes GS, Mott JC, Ross BB, Strang LB. The vascular resistance of the fetal and newly ventilated lung of the lamb. J Physiol 171: 61-79, 1964.
4. Cassin S, Dawes Ross GS, BB. Pulmonary blood flow and vascular resistance in immature fetal lambs. J Physiol 171: 80-89, 1964.
5. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Acute hypoxia increases cytosolic calcium in fetal pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 265: L53-L56, 1993.
6. Dawes GS, Mott JC, Widdicombe JG, Wyatt DG. Changes in the lungs of the newborn lamb. J Physiol 121: 141-162, 1953.
7. Furchgott RF. Studies on relaxation of rabbit aorta by sodium nitrite: The basis for the proposal that the acid-activatable inhibitory factor from bovine retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide. In: Vasodilatation, edited by Vanhoutte PM. New York, NY: Raven, 1988, p. 410-414.
8. Girgis RE, Mozammel S, Champion HC, Li D, Peng X, Shimoda L, Tuder RM, Johns RA, Hassoun PM. Regression of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Lung Cell Mol Physiol 292: L1105-L1110, 2007.
9. Grotendorst GR, Seppa HE, Kleinman HK, Martin GR. Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor. Proc Natl Acad Sci USA 78: 3669-3672, 1981.
10. Hahn AW, Resink TJ, Scott-Burden T, Powell J, Dohi Y, Buhler FR. Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: A novel autocrine function. Cell Regul 1: 649-659, 1990.
11. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothe-lium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84: 9265-9269, 1987.
12. Ivy DD, Kinsella JP, Abman SH. Physiologic characterization of endo-thelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest 93: 2141-2148, 1994.
13. Ivy DD, Rosenzweig EB, Lemarie JC, Brand M, Rosenberg D, Barst RJ. Long-term outcomes in children with pulmonary arterial hypertension treated with bosentan in real-world clinical settings. Am J Cardiol 106: 1332-1338, 2010.
14. Jankov RP, Kantores C, Belcastro R, Yi M, Tanswell AK. Endothe-lin-1 inhibits apoptosis of pulmonary arterial smooth muscle in the neonatal rat. Pediatr Res 60: 245-251, 2006.
15. Jawien A, Bowen-Pope DF, Lindner V, Schwartz SM, Clowes AW. Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. J Clin Invest 89: 507-511, 1992.
16. Kawut SM, Taichman DB, Archer-Chicko CL, Palevsky HI, Kimmel SE. Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis. Chest 123: 344-350, 2003.
17. Kim YM, Barnes EA, Alvira CM, Ying L, Reddy S, Cornfield DN. Hypoxia-inducible factor-1alpha in pulmonary artery smooth muscle cells lowers vascular tone by decreasing Myosin light chain phosphorylation. Circ Res 112: 1230-1233, 2013.
18. Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M. Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions. Am J Pathol 179: 1560-1572, 2011.
19. Kirkby NS, Hadoke PW, Bagnall AJ, Webb DJ. The endothelin system as a therapeutic target in cardiovascular disease: Great expectations or bleak house? Br J Pharmacol 153: 1105-1119, 2008.
20. Kisanuki YY, Emoto N, Ohuchi T, Widyantoro B, Yagi K, Nakayama K, Kedzierski RM, Hammer RE, Yanagisawa H, Williams SC, Rich-ardson JA, Suzuki T, Yanagisawa M. Low blood pressure in endothelial cell-specific endothelin 1 knockout mice. Hypertension 56: 121-128, 2010.
21. Madden JA, Vadula Ms, Kurup VP. Effects of hypoxia and other vasoactive agents on pulmonary and cerebral artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 263: L384-L393, 1992.
22. McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J, American College of Cardiology Foundation Task Force on Expert Consensus Documents, American Heart Association, American College of Chest Physicians, American Thoracic Society, Pulmonary Hypertension Association. ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc, and the Pulmonary Hypertension Association. J Am Coll Cardiol 53: 1573-1619, 2009.
23. Meoli DF, White RJ. Endothelin-1 induces pulmonary but not aortic smooth muscle cell migration by activating ERK1/2 MAP kinase. Can J Physiol Pharmacol 88: 830-839, 2010.
24. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 329: 2002-2012, 1993.
25. Morin FC 3rd, Stenmark KR. Persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 151: 2010-2032, 1995.
26. Mourani PM, Abman SH. Pulmonary vascular disease in bronchopulmonary dysplasia: Pulmonary hypertension and beyond. Curr Opin Pediatr 25: 329-337, 2013.
27. Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. Am J Physiol Lung Cell Mol Physiol 304: L549-L561, 2013.
28. Rabinovitch M. Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 122: 4306-4313, 2012.
29. Resink TJ, Scott-Burden T, Boulanger C, Weber E, Buhler FR. Internalization of endothelin by cultured human vascular smooth muscle cells: characterization and physiological significance. Mol Pharmacol 38: 244-252, 1990.
30. Resink TJ, Scott-Burden T, Buhler FR. Activation of multiple signal transduction pathways by endothelin in cultured human vascular smooth muscle cells. Eur J Biochem 189: 415-421, 1990.
31. Rubanyi GM, Polokoff MA. Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev 46: 325-415, 1994.
32. Rubin LJ. Primary pulmonary hypertension. N Engl J Med 336: 111-117, 1997.
33. Rubin LJ, Badesch DB, Barst RJ, Galie N, Black CM, Keogh A, Pulido T, Frost A, Roux S, Leconte I, Landzberg M, Simonneau G. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 346: 896-903, 2002.
34. Saam JR, Gordon JI. Inducible gene knockouts in the small intestinal and colonic epithelium. J Biol Chem 274: 38071-38082, 1999.
35. Shimoda LA, Sylvester JT, Sham JS. Chronic hypoxia alters effects of endothelin and angiotensin on K currents in pulmonary arterial myo-cytes. Am J Physiol Lung Cell Mol Physiol 277: L431-L439, 1999.
36. Stelzner TJ, O’Brien RF, Yanagisawa M, Sakurai T, Sato K, Webb S, Zamora M, McMurtry IF, Fisher JH. Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 262: L614-L620, 1992.
37. Wort SJ, Woods M, Warner TD, Evans TW, Mitchell JA. Cyclooxy-genase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. Mol Pharmacol 62: 1147-1153, 2002.
38. Wort SJ, Woods M, Warner TD, Evans TW, Mitchell JA. Endoge-nously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: Relevance to pathogenesis of pulmonary hypertension and vascular remodeling. Am J Respir Cell Mol Biol 25: 104-110, 2001.
39. Yamashita K, Discher DJ, Hu J, Bishopric NH, Webster KA. Molecular regulation of the endothelin-1 gene by hypoxia: Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2 and p300/CBP. J Biol Chem 276: 12645-12653, 2001.
40. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415, 1988.
41. Zamora MR, Stelzner TJ, Webb S, Panos RJ, Ruff LJ, Dempsey EC. Overexpression of endothelin-1 and enhanced growth of pulmonary artery smooth muscle cells from fawn-hooded rats. Am J Physiol Lung Cell Mol Physiol 270: L101-L109, 1996.