Lead nitrate induced testicular toxicity in diabetic and non-diabetic rats: Protective role of sodium selenite

Brazilian Archives of Biology and Technology

Volumn 58, Issue 1, 2015, Pages 68-74

  Apaydin, Fatma Gokce ^a   Kalender, Suna ^a   Bas, Hatice ^b   Demir, Filiz ^c   Kalender, Yusuf ^a  

^a GAZI UNIVERSITY   (Turkey)

^b BOZOK UNIVERSITY   (Turkey)

^c GAZIOSMANPASA UNIVERSITY   (Turkey)

Author keywords

Histopathology; Lead nitrate; Oxidative stress; Sodium selenite; Streptozotocin; Testicular toxicity

Indexed keywords

EID: 84922985167     PISSN: 15168913     EISSN: 16784324     Source Type: Journal    
DOI: 10.1590/S1516-8913201400025     Document Type: Article

References (43)

1. Acharya UR, Rathore RM, Mishra M. Role of vitamin C on lead acetate induced spermatogenesis in Swiss mice. Environ Toxicol Pharmacol. 2003; 13: 9-14.
2. Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105: 121-126.
3. Afridi HI., Kazi TG., Kazi N, Jamali MK, Arain MB, Jalbani N, et al. Evaluation of status of toxic metals in biological samples of diabetes mellitus patients. Diabetes Res Clin Pr. 2008; 80: 280-288.
4. Ahmed YF, Eldebaky HAA, Mahmoud KGhM, Nawito M. Effects of lead exposure on DNA damage and apoptosis in reproductive and vital organs in female rabbits. Global Veterinaria. 2012; 9: 401-408.
5. Chen YW, Yang CY, Huang CF, Hung DZ, Leung YM, Liu SH. Heavy metals, islet function and diabetes development. Islets. 2009; 1: 169-176.
6. Degirmenci I, Ustuner MC, Kalender Y, Kalender S, Gunes HV. The effects of acarbose and Rumex patientia L. on ultrastructural and biochemical changes of pancreatic B cells in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2005; 97:555-559.
7. Demir F, Uzun FG, Durak D, Kalender Y. Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin. Pestic Biochem Phys. 2011; 99: 77-81.
8. Dirican EK, Kalender Y. Dichlorvos induced testicular toxicity in male rats and the protective role of vitamins C and E. Exp Toxicol Pathol. 2012; 64: 821-830.
9. Durak D, Kalender S, Uzun FG, Demir F, Kalender Y. Mercury chloride-induced oxidative stress and the protective effect of vitamins C and E in human erythrocytes in vitro. Afr J Biotechnol. 2010; 9 (4): 488- 495.
10. Duzguner V, Kaya S. Effect of zinc on the lipid peroxidation and the antioxidant defense systems of the alloxan-induced diabetic rabbits. Free Radical Bio Med. 2007; 42: 1481-1486.
11. El-Sokkary GH, Abdel-Rahman GH, Kamel ES. Melatonin protects against lead-induced hepatic and renal toxicity in male rats. Toxicology. 2005; 213: 25-33.
12. Eraslan G, Saygi S, Essiz D, Aksoy A, Gul H, Macit E. Evaluation of aspect of some oxidative stress parameters using vitamin E, proanthocyanidin and N-acetylcysteine against exposure to cyfluthrin in mice. Pestic Biochem Phys. 2007; 88: 43-49.
13. Fahim MA, Tariq S, Adeghate E. Vitamin E modifies the ultrastructure of testis and epididymis in mice exposed to lead intoxication. Ann Anat. 2013; 195: 272-277.
14. Farmand F, Ehdaie A, Roberts CK, Sindhu RK. Leadinduced dysregulation of superoxide dismutases, catalase, glutathione peroxidase, and guanylate cyclase. Environ Res. 2005; 98: 33-39.
15. Flora SJS, Pande M, Bhadauria S, Kannan GM. Combined administration of taurine and meso 2,3- dimercaptosuccinic acid in the treatment of chronic lead intoxication in rats. Hum Exp Toxicol. 2004a; 23: 157- 166.
16. Flora SJS, Pande M, Kannan GM, Mehta A. Lead induced oxidative stress and its recovery following coadministration ofmelatonin or n-acetylcysteine during chelation with succimer in male rats. Cell Mol Biol. 2004b; 50: 543-551.
17. Habig WH, Pabst MJ, Jakoby WB. Glutathione-Stransferases: the first enzymatic step in mercapturic acid formation. J Biol Chem. 1974; 249: 7130-7139.
18. Jin L, Xue H-Y, Jin L-J, Li S-Y, Xu Y-P. Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes. Eur J Pharmacol. 2008; 582: 162-167.
19. Kade IJ, Borges VC, Savegnago L, Ibukun EO, Zeni G, Nogueira CW, Rocha JBT. Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats. Cell Biol Toxicol. 2009a; 25: 415-424
20. Kade IJ, Nogueira CW, Rocha JBT. Diphenyl diselenide and streptozotocin did not alter cerebral glutamatergic and cholinergic systems but modulate antioxidant status and sodium pump in diabetic rats. Brain Res. 2009b; 1284: 202-211.
21. Kalender S, Uzun FG, Demir F, Uzunhisarcikli M, Aslanturk A. Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E. Food Chem Toxicol. 2013; 55: 456-462.
22. Kara H, Cevik A, Konar V, Dayangac A, Yilmaz M. Protective effects of antioxidants against cadmiuminduced oxidative damage in rat testes. Biol Trace Elem Res. 2007; 120: 205-211.
23. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 19: 265.
24. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974; 47: 469-474.
25. Navarro-Casado L, Juncos-Tobarra MA, Chafer-Rudilla M, de Onzono LI, Blazquez-Cabrera JA, Miralles- Garcia JM. Effect of experimental diabetes and STZ on male fertility capacity. Study in rats. J Androl. 2010; 31: 584-592.
26. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95: 351-358.
27. Paglia DE. Valentine WN. Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase. J Lab Clin Med. 1967; 70: 158-165.
28. Patra RC, Rautray AK, Swarup D. Oxidative stress in lead and cadmium toxicity and its amelioration. Vet Med Internat. 2011; 2011: 1-9.
29. Prabakaran D, Ashokkumar N. Protective effect of esculetin on hyperglycemia-mediated oxidative damage in the hepatic and renal tissues of experimental diabetic rats. Biochimie. 2013; 95: 366-373.
30. Renugadevi J, Prabu SM. Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol. 2010; 62: 171-181.
31. Saddala RR, Thopireddy L, Ganapathi N, Kesireddy SR. Regulation of cardiac oxidative stress and lipid peroxidation in streptozotocin-induced diabetic rats treated with aqueous extract of Pimpinella tirupatiensis tuberous root. Exp Toxicol Pathol. 2013; 65: 15-19.
32. Sainath SB, Meena R, Supriya Ch, Reddy KP, Reddy PS. Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health in male rats. Environ Toxicol Pharmacol. 2011; 32: 146-154.
33. Schmatz R, Perreira LB, Stefanello N, Mazzanti C, Spanevello R, Gutierres J, et al. Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats. Biochimie. 2012; 94: 374-383.
34. Sekeroglu MR, Sahin H, Dülger H, Algün E. The effect of dietary treatment on erythrocyte lipid peroxidation, superoxide dismutase, glutathione peroxidase and serum lipid peroxidation in patients with type 2 diabetes mellitus. Clin Biochem. 2000; 33: 669-674.
35. Shanmugam KR, Mallikarjuna K, Nishant K, Kuo CH, Reddy KS. Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues. Food Chem Toxicol. 2011; 124:1436-1442.
36. Shilo S, Aronis A, Komarnitsky R, Tirosh O. Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection. Biochem J. 2003; 370: 283-290.
37. Uzun FG, Demir F, Kalender S. Bas H, Kalender Y. Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats. Food Chem Toxicol. 2010; 48: 1714-1720.
38. Uzunhisarcikli M, Kalender Y. Protective effects of vitamins C and E against hepatotoxicity induced by methyl parathion in rats. Ecotox Environ Safe. 2011; 74: 2112-2118.
39. Wang C, Zhang Y, Liang J, Shan G, Wang Y, Shi Q. Impacts of ascorbic acid and thiamine supplementation at different concentrations on lead toxicity in testis. Clin Chim Acta. 2006; 370: 82-88.
40. Wang M-Z, Jia X-Y. Low levels of lead exposure induce oxidative damage and DNA damage in the testes of the frog Rana nigromaculata. Ecotoxicology. 2009; 18: 94- 99.
41. Xia D, Yu X, Liao S, Shao Q. Mou, H, Ma W. Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats. J Ethnopharmacol. 2010; 130: 414-420.
42. Xiang D, Zhu J, Jin S, Hu Y, Tan F, Yang W. Expression and function analysis of metallothionein in the testis of Portunus trituberculatus exposed to cadmium. Aquatic Toxicology. 2013; 140-141: 1-10.
43. Zhang R, Niu Y, Li Y, Zhao C, Song B, Li Y, Zhao Y. Acute toxicity study of the interaction between titanium dioxide nanoparticles and lead acetate in mice. Environ Toxicol Pharmacol. 2010; 30: 52-60.