Methods for the quantification of lysosomal membrane permeabilization: A hallmark of lysosomal cell death

Methods in Cell Biology

Volumn 126, Issue , 2015, Pages 261-285

  Aits, Sonja ^a   Jäättelä, Marja ^a   Nylandsted, Jesper ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

Cathepsins; Death pathway; Galectins; LMP; Lysosomal cell death; Lysosomal membrane permeabilization; Method

Indexed keywords

CATHEPSIN; DETERGENT; DEXTRAN; DIGITONIN; FLUORESCEIN DERIVATIVE; FLUORESCEIN-DEXTRAN; FLUORESCENT DYE;

APOPTOSIS; CELL FRACTIONATION; CELL MEMBRANE PERMEABILITY; CYTOSOL; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; HUMAN; LYSOSOME; MCF 7 CELL LINE; METABOLISM; PHYSIOLOGY;

APOPTOSIS; CATHEPSINS; CELL FRACTIONATION; CELL MEMBRANE PERMEABILITY; CYTOSOL; DETERGENTS; DEXTRANS; DIGITONIN; FLUORESCEINS; FLUORESCENT DYES; HUMANS; LYSOSOMES; MCF-7 CELLS; MICROSCOPY, FLUORESCENCE;

EID: 84922947461     PISSN: 0091679X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.mcb.2014.10.032     Document Type: Article

References (39)

1. Aits S., Jaattela M. Lysosomal Cell Death at a glance. J Cell Sci 2013, 126:1905-1912.
2. Aits S., Kricker J., Liu B., Ellegaard A.M., Hämälistö S., Tvingsholm S., et al. Galectin puncta mark individual leaky lysosomes even in the absence of cell death. Submitted 2014.
3. Bidere N., Lorenzo H.K., Carmona S., Laforge M., Harper F., Dumont C., et al. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. Journal of Biological Chemistry 2003, 278:31401-31411.
4. Bitensky L. Modifications to the Gomori acid phosphatase technique for controlled temperature frozen sections 1963, lO4, 193-196. Q.fi microsc. Sci. Ref Type: Generic.
5. Boya P., Andreau K., Poncet D., Zamzami N., Perfettini J.L., Metivier D., et al. Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. Journal of Experimental Medicine 2003, 197:1323-1334.
6. Boya P., Kroemer G. Lysosomal membrane permeabilization in cell death. Oncogene 2008, 27:6434-6451.
7. Brunk U.T., Dalen H., Roberg K., Hellquist H.B. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radical Biology and Medicine 1997, 23:616-626.
8. Brunk U.T., Neuzil J., Eaton J.W. Lysosomal involvement in apoptosis. REDOX Report 2001, 6:91-97.
9. Cirman T., Oresic K., Mazovec G.D., Turk V., Reed J.C., Myers R.M., et al. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. Journal of Biological Chemistry 2004, 279:3578-3587.
10. De Duve C. Lysosomes revisited. European Journal of Biochemistry 1983, 137:391-397.
11. De Duve C., Pressman B.C., Gianetto R., Wattiaux R., Appelmans F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochemical Journal 1955, 60:604-617.
12. Ellegaard A.M., Groth-Pedersen L., Oorschot V., Klumperman J., Kirkegaard T., Nylandsted J., et al. Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance. Molecular Cancer Therapeutics 2013, 12:2018-2030.
13. Firestone R.A., Pisano J.M., Bonney R.J. Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents. Journal of Medicinal Chemistry 1979, 22:1130-1133.
14. Foghsgaard L., Wissing D., Mauch D., Lademann U., Bastholm L., Boes M., et al. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. Journal of Cell Biology 2001, 153:999-1010.
15. Gerasimenko J.V., Gerasimenko O.V., Petersen O.H. Membrane repair: Ca(2+)-elicited lysosomal exocytosis. Current Biology 2001, 11:R971-R974.
16. Groth-Pedersen L., Ostenfeld M.S., Hoyer-Hansen M., Nylandsted J., Jaattela M. Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine. Cancer Research 2007, 67:2217-2225.
17. Gyrd-Hansen M., Farkas T., Fehrenbacher N., Bastholm L., Hoyer-Hansen M., Elling F., et al. Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9. Molecular and Cellular Biology 2006, 26:7880-7891.
18. Kagedal K., Zhao M., Svensson I., Brunk U.T. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochemical Journal 2001, 359:335-343.
19. Kallunki T., Olsen O.D., Jaattela M. Cancer-associated lysosomal changes: friends or foes?. Oncogene 2013, 32:1995-2004.
20. Kirkegaard T., Jaattela M. Lysosomal involvement in cell death and cancer. Biochimica et Biophysica Acta 2009, 1793:746-754.
21. Kirkegaard T., Roth A.G., Petersen N.H., Mahalka A.K., Olsen O.D., Moilanen I., et al. Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature 2010, 463:549-553.
22. Kolter T., Sandhoff K. Lysosomal degradation of membrane lipids. FEBS Letters 2010, 584:1700-1712.
23. Kreuzaler P.A., Staniszewska A.D., Li W., Omidvar N., Kedjouar B., Turkson J., et al. Stat3 controls lysosomal-mediated cell death in vivo. Nature Cell Biology 2011, 13:303-309.
24. Kroemer G., Jaattela M. Lysosomes and autophagy in cell death control. Nature Reviews Cancer 2005, 5:886-897.
25. Kurz T., Eaton J.W., Brunk U.T. The role of lysosomes in iron metabolism and recycling. International Journal of Biochemistry and Cell Biology 2011, 43:1686-1697.
26. Link G., Pinson A., Hershko C. Iron loading of cultured cardiac myocytes modifies sarcolemmal structure and increases lysosomal fragility. Journal of Laboratory and Clinical Medicine 1993, 121:127-134.
27. Li W., Yuan X., Nordgren G., Dalen H., Dubowchik G.M., Firestone R.A., et al. Induction of cell death by the lysosomotropic detergent MSDH. FEBS Letters 2000, 470:35-39.
28. Moin K., Cao L., Day N.A., Koblinski J.E., Sloane B.F. Tumor cell membrane cathepsin B. Biological Chemistry 1998, 379:1093-1099.
29. Nylandsted J., Gyrd-Hansen M., Danielewicz A., Fehrenbacher N., Lademann U., Hoyer-Hansen M., et al. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. Journal of Experimental Medicine 2004, 200:425-435.
30. Nylandsted J., Rohde M., Brand K., Bastholm L., Elling F., Jaattela M. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:7871-7876.
31. Palermo C., Joyce J.A. Cysteine cathepsin proteases as pharmacological targets in cancer. Trends in Pharmacological Sciences 2008, 29:22-28.
32. Petersen N.H., Olsen O.D., Groth-Pedersen L., Ellegaard A.M., Bilgin M., Redmer S., et al. Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase. Cancer Cell 2013, 24:379-393.
33. Pryor P.R., Luzio J.P. Delivery of endocytosed membrane proteins to the lysosome. Biochimica et Biophysica Acta 2009, 1793:615-624.
34. Rammer P., Groth-Pedersen L., Kirkegaard T., Daugaard M., Rytter A., Szyniarowski P., et al. A complex of bovine lactalbumin and oleic acid (BAMLET) activates a lysosomal cell death program in cancer cells. Mol Cancer Therapy 2010, 9:24-32.
35. Schotte P., Declercq W., Van Huffel S., Vandenabeele P., Beyaert R. Non-specific effects of methyl ketone peptide inhibitors of caspases. FEBS Letters 1999, 442:117-121.
36. Silverman G.A., Bartuski A.J., Cataltepe S., Gornstein E.R., Kamachi Y., Schick C., et al. SCCA1 and SCCA2 are proteinase inhibitors that map to the serpin cluster at 18q21.3. Tumour Biology 1998, 19:480-487.
37. Stoka V., Turk V., Turk B. Lysosomal cysteine cathepsins: signaling pathways in apoptosis. Biological Chemistry 2007, 388:555-560.
38. Suminami Y., Nawata S., Kato H. Biological role of SCC antigen. Tumour Biology 1998, 19:488-493.
39. Vasiljeva O., Turk B. Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion. Biochimie 2008, 90:380-386.