Mechanism of Reversible Self-Association of a Monoclonal Antibody: Role of Electrostatic and Hydrophobic Interactions

Journal of Pharmaceutical Sciences

Volumn 104, Issue 2, 2015, Pages 577-586

  Esfandiary, Reza ^a   Parupudi, Arun ^a   Casas Finet, Jose ^a   Gadre, Dhanesh ^a   Sathish, Hasige ^a  

^a MEDIMMUNE   (United States)

Author keywords

Anions; Light scattering (dynamic); Light scattering (static); Monoclonal antibody; Protein formulation; Protein protein interactions; Thermodynamics

Indexed keywords

AROMATIC AMINO ACID; BUFFER; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; CITRATE PHOSPHATE DEXTROSE; CITRIC ACID; GLUCOSE; HISTIDINE; IMMUNOGLOBULIN G; PROTEIN BINDING;

ARTICLE; ENTHALPY; ENTROPY; HYDRODYNAMICS; HYDROPHOBICITY; LIGHT SCATTERING; MOLECULAR WEIGHT; PH; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; STATIC ELECTRICITY; CHEMICAL PHENOMENA; METABOLISM; PHYSIOLOGY; RADIATION SCATTERING;

ANTIBODIES, MONOCLONAL; CITRATES; GLUCOSE; HISTIDINE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN G; PROTEIN BINDING; SCATTERING, RADIATION; STATIC ELECTRICITY;

EID: 84922901105     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24237     Document Type: Article

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