Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer

American Journal of Respiratory and Critical Care Medicine

Volumn 191, Issue 4, 2015, Pages 437-447

  Schmall, Anja ^a   Al Tamari, Hamza M ^a   Herold, Susanne ^b   Kampschulte, Marian ^b   Weigert, Andreas ^c   Wietelmann, Astrid ^a   Vipotnik, Natasha ^a   Grimminger, Friedrich ^b   Seeger, Werner ^a,b   Pullamsetti, Soni Savai ^a,b   Savai, Rajkumar ^a,b  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

CCR2; CX3CR1; Lung cancer; Macrophages; Microenvironment

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; CHEMOKINE RECEPTOR CX3CR1; CLODRONIC ACID; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; CCL2 PROTEIN, HUMAN; CCL2 PROTEIN, MOUSE; CCR2 PROTEIN, HUMAN; CCR2 PROTEIN, MOUSE; CHEMOKINE RECEPTOR; CX3CL1 PROTEIN, HUMAN; CX3CL1 PROTEIN, MOUSE; CX3CR1 PROTEIN, HUMAN; CX3CR1 PROTEIN, MOUSE; FRACTALKINE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR MARKER;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CELL COMMUNICATION; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; DISEASE SEVERITY; HUMAN; HUMAN CELL; LARGE CELL CARCINOMA; LEWIS CARCINOMA; LUNG ADENOCARCINOMA; LUNG CANCER; MACROPHAGE; METASTASIS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PHENOTYPE; POLARIZATION; PRIMARY TUMOR; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SQUAMOUS CELL LUNG CARCINOMA; SURVIVAL; TUMOR GROWTH; UPREGULATION; ADENOCARCINOMA; ANIMAL; CANCER STAGING; LUNG TUMOR; METABOLISM; PATHOLOGY; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; CARCINOMA, LARGE CELL; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CHEMOKINE CCL2; CHEMOKINE CX3CL1; HUMANS; LUNG NEOPLASMS; MACROPHAGES; MICE; NEOPLASM METASTASIS; NEOPLASM STAGING; RECEPTOR CROSS-TALK; RECEPTORS, CCR2; RECEPTORS, CHEMOKINE; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84922900718     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201406-1137OC     Document Type: Article

References (31)

1. Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011;61:212-236.
2. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57-70.
3. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420: 860-867.
4. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008;8:958-969.
5. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011;11:723-737.
6. Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010;141:39-51.
7. Zhu XD, Zhang JB, Zhuang PY, Zhu HG, Zhang W, Xiong YQ, Wu WZ, Wang L, Tang ZY, Sun HC. High expression of macrophage colonystimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol 2008;26:2707-2716.
8. Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity 2010;32:593-604.
9. Mellado M, Rodríguez-Frade JM, Aragay A, del Real G, Martín AM, Vila-Coro AJ, Serrano A, Mayor F Jr, Martínez-A C. The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J Immunol 1998;161:805-813.
10. Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, et al. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 2012;22:91-105.
11. Franklin RA, Liao W, Sarkar A, Kim MV, Bivona MR, Liu K, Pamer EG, Li MO. The cellular and molecular origin of tumor-associated macrophages. Science 2014;344:921-925.
12. Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, Kaiser EA, Snyder LA, Pollard JW. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 2011; 475:222-225.
13. Bailey C, Negus R, Morris A, Ziprin P, Goldin R, Allavena P, Peck D, Darzi A. Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer. Clin Exp Metastasis 2007;24:121-130.
14. Erreni M, Solinas G, Brescia P, Osti D, Zunino F, Colombo P, Destro A, Roncalli M, Mantovani A, Draghi R, et al. Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1. Eur J Cancer 2010;46: 3383-3392.
15. Sciumè G, Soriani A, Piccoli M, Frati L, Santoni A, Bernardini G. CX3CR1/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor-b1. Neuro-oncol 2010;12: 701-710.
16. Tardáguila M, Mira E, García-Cabezas MA, Feijoo AM, Quintela-Fandino M, Azcoitia I, Lira SA, Mañes S. CX3CL1 promotes breast cancer via transactivation of the EGF pathway. Cancer Res 2013;73:4461-4473.
17. Burnett SH, Beus BJ, Avdiushko R, Qualls J, Kaplan AM, Cohen DA. Development of peritoneal adhesions in macrophage depleted mice. J Surg Res 2006;131:296-301.
18. Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 2008;8:533-544.
19. Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004;104:2224-2234.
20. Zhang J, Patel L, Pienta KJ. CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis. Cytokine Growth Factor Rev 2010;21:41-48.
21. Qian BZ, Pollard JW. New tricks for metastasis-associated macrophages. Breast Cancer Res 2012;14:316.
22. Zaynagetdinov R, Sherrill TP, Polosukhin VV, Han W, Ausborn JA, McLoed AG, McMahon FB, Gleaves LA, Degryse AL, Stathopoulos GT, et al. A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. J Immunol 2011;187:5703-5711.
23. Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL, Klemke RL. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS ONE 2009;4:e6713.
24. Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, et al. Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci USA 2012;109:2491-2496.
25. Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP. Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential. PLoS ONE 2012;7:e35040.
26. Delebecq TJ, Porte H, Zerimech F, Copin MC, Gouyer V, Dacquembronne E, Balduyck M, Wurtz A, Huet G. Overexpression level of stromelysin 3 is related to the lymph node involvement in non-small cell lung cancer. Clin Cancer Res 2000;6:1086-1092.
27. Zheng S, Chang Y, Hodges KB, Sun Y, Ma X, Xue Y, Williamson SR, Lopez-Beltran A, Montironi R, Cheng L. Expression of KISS1 and MMP-9 in non-small cell lung cancer and their relations to metastasis and survival. Anticancer Res 2010;30:713-718.
28. Fakhoury HM, Noureddine S, Tamim H, Chmaisse H, Makki R. Association of MMP3-1171(5A.6A) polymorphism with lung cancer in Lebanon. Genet Test Mol Biomarkers 2012;16:988-990.
29. Yang X, Lu P, Ishida Y, Kuziel WA, Fujii C, Mukaida N. Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization. Int J Cancer 2006;118:335-345.
30. Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, et al. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res 2013;73:1128-1141.
31. Lança T, Costa MF, Gonçalves-Sousa N, Rei M, Grosso AR, Penido C, Silva-Santos B. Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic gd T lymphocytes to tumor beds. J Immunol 2013;190: 6673-6680.