Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing

ChemBioChem

Volumn 9, Issue 3, 2008, Pages 389-400

  Geske, Grant D ^a   O'Neil, Jennifer C ^a   Miller, David M ^b   Wezeman, Rachel J ^c   Mattmann, Margrith E ^a   Lin, Qi ^a   Blackwell, Helen E ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b PFIZER INC   (United States)

^c Scientific Protein Laboratories LLC   (United States)

Author keywords

Combinatorial chemistry; Gram negative bacteria; Homoserine lactones; Quorum sensing; Structure activity relationships

Indexed keywords

ACYLATED HOMOSERINE LACTONE; LACTONE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; GAMMA BUTYROLACTONE; HOMOSERINE LACTONE;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; GRAM NEGATIVE BACTERIUM; LIGAND BINDING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; PROTEIN TARGETING; QUORUM SENSING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; ACYLATION; CHEMICAL STRUCTURE; CHEMISTRY;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

4-BUTYROLACTONE; ACYLATION; MOLECULAR STRUCTURE; QUORUM SENSING;

EID: 45749124990     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700551     Document Type: Article

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