Heterogeneous recognition of beta 2-glycoprotein I by antibodies from antiphospholipid syndrome patients

Thrombosis and Haemostasis

Volumn 84, Issue 3, 2000, Pages 374-380

  Guerin, J ^a   Sim, R ^a   Yu, B B ^a   Ferluga, J ^a   Feighery, C ^a   Jackson, J ^a  

^a ST JAMES S HOSPITAL   (Ireland)

Author keywords

Antibodies; Antiphospholipid syndrome; Beta 2 glycoprotein I; Heterogeneity; Species

Indexed keywords

BETA2 GLYCOPROTEIN 1; EPITOPE; MONOCLONAL ANTIBODY; PANCREATIC ELASTASE; PHOSPHOLIPID; PHOSPHOLIPID ANTIBODY;

ANIMAL CELL; ANTIBODY AFFINITY; ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CELL HETEROGENEITY; CLINICAL ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; RABBIT;

EID: 0033832063     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1614031     Document Type: Article

References (50)

1. The anticardiolipin syndrome
2. A 'primary' antiphospholipid syndrome?
3. The antiphospholipid syndrome: Ten years on
4. Antiphospholipid antibodies: Anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders
5. The antiphospholipid syndrome in infectious diseases
6. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor
7. Anticardiolipin co-factor(s) and differential diagnosis of autoimmune disease
8. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor
9. Beta 2-Glycoprotein I: A plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway
10. Prothrombinase activity of human platelets is inhibited by beta 2-glycoprotein-I
11. Beta 2-glycoprotein I in thrombosis: Evidence for a role as a natural anticoagulant
12. Structure-function relationships of the complement components
13. Complete nucleotide and deduced amino acid sequence of human β2-glycoprotein 1
14. Molecular definition of human β2-glycoprotein 1 (β2-GP1) by cDNA cloning and inter-species differences of β2-GP1 in alternation of anticardiolipin binding
15. Activity, disulphide mapping and structural modelling of the fifth domain of human beta 2-glycoprotein I
16. The fifth domain of beta 2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies
17. Epitope specificity of monoclonal anti-beta 2-glycoprotein I antibodies derived from patients with the antiphospholipid syndrome
18. Site-directed mutagenesis of recombinant human beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity
19. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: Beta 2-glycoprotein I (apolipoprotein H)
20. β2-glycoprotein 1 (β2GP1) enhances cardiolipin binding activity but is not the antigen for antiphospholipid antibodies
21. Anti-beta 2-glycoprotein I autoantibodies from patients with the 'antiphospholipid' syndrome bind to beta 2-glycoprotein I with low affinity: Dimerization of beta 2-glycoprotein I induces a significant increase in anti-beta 2-glycoprotein I antibody affinity
22. Binding properties of antibodies to prothrombin and beta2-glycoprotein I (beta2-GPI) assayed by ELISA and dot blot
23. Antiphospholipid antibodies require beta 2-glycoprotein I (apolipoprotein H) as cofactor
24. Changes in β2-glycoprotein 1 antigenicity induced by phospholipid binding
25. Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface
26. Beta 2-Glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome
27. Human beta 2-glycoprotein I as an anticardiolipin cofactor determined using mutants expressed by a baculovirus system
28. Target recognition of β2-glycoprotein I (β2-GPI)-dependent anticardiolipin antibodies: Evidence for involvement of the fourth domain of β2-GPI in antibody binding
29. Anti-β2-glycoprotein I (β2-GPI) autoantibodies recognize an epitope on the first domain of β2-GPI
30. Primary antiphospholipid syndrome
31. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome
32. Antibodies to beta2-glycoprotein I - A specific marker for the antiphospholipid syndrome
33. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
34. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
35. Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin
36. Functional and binding studies of the roles of prothrombin and beta 2-glycoprotein I in the expression of lupus anticoagulant activity
37. Comparison of an enzyme-linked immunosorbent assay for antibodies to beta 2-glycoprotein I and a conventional anticardiolipin immunoassay
38. The use of an anti-b2-glycoprotein 1 assay for discrimination between anticardiolipin antibodies associated with infection and increased risk of thrombosis
39. Antibodies to prothrombin in antiphospholipid syndrome and inflammatory disorders
40. Characterization of binding of human beta 2-glycoprotein I to cardiolipin
41. 'Anticardiolipin' autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding
42. The anti-beta2-glycoprotein I activity in human anti-phospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native beta2-glycoprotein I and preserved during species' evolution
43. Identification of a region of beta 2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity
44. Anti beta 2 glycoprotein I antibodies: Detection and association with thrombosis
45. Some 'antiphospholipid antibodies' bind to β2-glycoprotein 1 in the absence of phospholipid
46. Clinical manifestations of the antiphospholipid syndrome in patients with systemic lupus erythematosus associate more strongly with anti-beta 2-glycoprotein-I than with antiphospholipid antibodies
47. Anticardiolipin and anti-beta 2-GPI are two distinct populations of autoantibodies
48. The primary structure of rat beta 2-glycoprotein I
49. Characterization and acute phase modulation of canine apolipoprotein H (beta 2-glycoprotein I)
50. Monoclonal antibodies from NZW X BXSB F1 mice to β2-glycoprotein I and cardiolipin