Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA

Journal of Biological Chemistry

Volumn 290, Issue 7, 2015, Pages 4010-4021

  Lu, Xiuxiu ^a   Zhang, Tianlong ^b   Xu, Zeng ^a   Liu, Shanshan ^a   Zhao, Bin ^a   Lan, Wenxian ^a   Wang, Chunxi ^a   Ding, Jianping ^b   Cao, Chunyang ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BINDING ENERGY; DNA;

BINDING MODES; CYTIDINE DEAMINASE; DIMER STRUCTURE; FULL-LENGTH ENZYMES; SINGLE-STRANDED DNA; STRUCTURAL MODELING;

CRYSTAL STRUCTURE;

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; DIMER; MONOMER; SINGLE STRANDED DNA; APOBEC3G PROTEIN, HUMAN; CYTIDINE DEAMINASE; PROTEIN BINDING;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEAMINATION; DNA BINDING; ENZYME ASSAY; ENZYME BINDING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; NONHUMAN; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; STRUCTURE ANALYSIS; WILD TYPE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; METABOLISM; PROTEIN MULTIMERIZATION; X RAY CRYSTALLOGRAPHY;

CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTIDINE DEAMINASE; DEAMINATION; DNA, SINGLE-STRANDED; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION;

EID: 84922806753     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.624262     Document Type: Article

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