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Volumn 13, Issue 8, 2015, Pages 2423-2431

Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: Lead optimization and structure activity profiling

(9) Jeankumar, Variam Ullas a Reshma, Rudraraju Srilakshmi a Janupally, Renuka a Saxena, Shalini a Sridevi, Jonnalagadda Padma a Medapi, Brahmam a Kulkarni, Pushkar b Yogeeswari, Perumal a Sriram, Dharmarajan a

a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE (India)

b UNIVERSITY OF HYDERABAD (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOADDITION; MOLECULES;

CYCLOADDITION REACTION; DIFFERENTIAL SCANNING FLUORIMETRY; LEAD OPTIMIZATION; MEDICINAL CHEMISTRY; MOLECULAR DOCKING; MYCOBACTERIUM TUBERCULOSIS; SELECTIVITY INDEX; STRUCTURE ACTIVITY;

STRUCTURAL OPTIMIZATION;

BACTERIA (MICROORGANISMS); DANIO RERIO; MYCOBACTERIUM TUBERCULOSIS;

ADENOSINE TRIPHOSPHATASE; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; TUBERCULOSTATIC AGENT;

ANIMAL; ANIMAL MODEL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MOUSE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ZEBRA FISH;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; CYCLIZATION; DNA GYRASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; MODELS, ANIMAL; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS; ZEBRAFISH;

EID: 84922774664 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/c4ob02049a Document Type: Article

Times cited : (26)

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