Gyrase ATPase domain as an antitubercular drug discovery platform: Structure-based design and lead optimization of nitrothiazolyl carboxamide analogues

ChemMedChem

Volumn 9, Issue 8, 2014, Pages 1850-1859

  Jeankumar, Variam Ullas ^a   Renuka, Janupally ^a   Kotagiri, Sonali ^a   Saxena, Shalini ^a   Kakan, Shruti Singh ^a   Sridevi, Jonnalagadda Padma ^a   Yellanki, Swapna ^b   Kulkarni, Pushkar ^b   Yogeeswari, Perumal ^a   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b UNIVERSITY OF HYDERABAD   (India)

Author keywords

DNA gyrase; enzymes; inhibitors; tuberculosis; virtual screening

Indexed keywords

1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 AMINE; 1 METHYL N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H INDOLE 2 CARBOXAMIDE; 3,4 DIBROMO 5 METHYL N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H PYRROLE 2 CARBOXAMIDE; 3,4 DICHLORO 5 METHYL N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H PYRROLE 2 CARBOXAMIDE; 5 CHLORO 1 METHYL N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H INDOLE 2 CARBOXAMIDE; 5 FLUORO 1 METHYL N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H INDOLE 2 CARBOXAMIDE; 5 FLUORO N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H INDOLE 2 CARBOXAMIDE; 5 METHOXY 1 METHYL N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H INDOLE 2 CARBOXAMIDE; 5 METHOXY N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H INDOLE 2 CARBOXAMIDE; 5 METHYL N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H PYRROLE 2 CARBOXAMIDE; 5 METHYL N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL]FURAN 2 CARBOXAMIDE; 5 METHYL N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL]THIOPHENE 2 CARBOXAMIDE; 5 NITRO N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL]FURAN 2 CARBOXAMIDE; 5 NITRO N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL]THIOPHENE 2 CARBOXAMIDE; AMIDE; DNA TOPOISOMERASE (ATP HYDROLYSING) B; ISONIAZID; MOXIFLOXACIN; N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H INDOLE 2 CARBOXAMIDE; N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL] 1H PYRROLE 2 CARBOXAMIDE; N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL]FURAN 2 CARBOXAMIDE; N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL]PICOLINAMIDE; N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL]PYRROLIDINE 2 CARBOXAMIDE; N [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL]THIOPHENE 2 CARBOXAMIDE; NITROTHIAZOLYL CARBOXAMIDE DERIVATIVE; NOVOBIOCIN; RIFAMPICIN; TERT BUTYL [1 (5 NITROTHIAZOL 2 YL)PIPERIDIN 4 YL]CARBAMATE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); THIAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; BACTERICIDAL ACTIVITY; BINDING AFFINITY; CARDIOTOXICITY; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; FLUOROMETRY; HYDROGEN BOND; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HEART RATE; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ZEBRA FISH;

AMIDES; ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DNA GYRASE; DRUG DESIGN; HEART RATE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; ZEBRAFISH;

EID: 84905164984     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201402035     Document Type: Article

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