Optimization of the adult zebrafish ECG method for assessment of drug-induced QTc prolongation

Journal of Pharmacological and Toxicological Methods

Volumn 67, Issue 2, 2013, Pages 115-120

  Chaudhari, Girish Hari ^a   Chennubhotla, Keerthana Sarma ^a   Chatti, Kiranam ^a   Kulkarni, Pushkar ^a  

^a UNIVERSITY OF HYDERABAD   (India)

Author keywords

Arrhythmia; ECG; QT interval; Safety pharmacology; Terfenadine; Zebrafish

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; DIMETHYL SULFOXIDE; PANCURONIUM; TERFENADINE;

ACCLIMATIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; ATRIOVENTRICULAR BLOCK; CONTROLLED STUDY; CORRELATION ANALYSIS; DEATH; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG SCREENING; ELECTROCARDIOGRAPHY; FLOW RATE; HEART PROARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; MALE; NONHUMAN; PERFUSION; PROCESS OPTIMIZATION; QT PROLONGATION; REPRODUCIBILITY; TORSADE DES POINTES; ZEBRA FISH;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; INJECTIONS, INTRAPERITONEAL; LONG QT SYNDROME; MALE; REPRODUCIBILITY OF RESULTS; TERFENADINE; ZEBRAFISH;

ANIMALIA; DANIO RERIO;

EID: 84875251922     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2013.01.007     Document Type: Article

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