Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3 H)-one

Journal of the American Chemical Society

Volumn 137, Issue 5, 2015, Pages 1738-1741

  Bouley, Renee ^a   Kumarasiri, Malika ^a   Peng, Zhihong ^a   Otero, Lisandro H ^b   Song, Wei ^a   Suckow, Mark A ^a   Schroeder, Valerie A ^a   Wolter, William R ^a   Lastochkin, Elena ^a   Antunes, Nuno T ^a   Pi, Hualiang ^a   Vakulenko, Sergei ^a   Hermoso, Juan A ^b   Chang, Mayland ^a   Mobashery, Shahriar ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOCHEMISTRY;

CELL WALL BIOSYNTHESIS; FUNCTIONAL ASSAYS; IN-SILICO; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PENICILLIN- BINDING PROTEINS; QUINAZOLINES; QUINAZOLINONES; RESISTANT BACTERIA;

ANTIBIOTICS;

3 (3 CARBOXYPHENYL) 2 (4 CYANOSTYRYL)QUINAZOLIN 4 (3H)ONE; ANTIBIOTIC AGENT; CIPROFLOXACIN; FOSFOMYCIN; LINEZOLID; MEROPENEM; PENICILLIN BINDING PROTEIN; RIFAMPICIN; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN; (E)-3-(3-CARBOXYPHENYL)-2-(4-CYANOSTYRYL)QUINAZOLIN-4(3H)-ONE; 4-HYDROXYQUINAZOLINE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; MECA PROTEIN, STAPHYLOCOCCUS AUREUS; QUINAZOLINONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING SITE; BIOSYNTHESIS; COMPARATIVE STUDY; CROSS LINKING; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONFORMATION; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG SCREENING; DRUG SYNTHESIS; ELIMINATION HALF-LIFE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MACROMOLECULE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MOLECULAR DOCKING; MOUSE; NONHUMAN; PROTEIN BINDING; RAT; STAPHYLOCOCCUS AUREUS; VOLUME OF DISTRIBUTION; BIOAVAILABILITY; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR MODEL; PROTEIN CONFORMATION; STAPHYLOCOCCUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOLOGICAL AVAILABILITY; DRUG DISCOVERY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PENICILLIN-BINDING PROTEINS; PROTEIN CONFORMATION; QUINAZOLINONES; STAPHYLOCOCCUS;

EID: 84922762182     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b00056     Document Type: Article

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