Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics

Journal of the American Chemical Society

Volumn 136, Issue 28, 2014, Pages 9814-9817

  Fishovitz, Jennifer ^a   Rojas Altuve, Alzoray ^b   Otero, Lisandro H ^b   Dawley, Matthew ^a   Carrasco López, Cesar ^b   Chang, Mayland ^a   Hermoso, Juan A ^b   Mobashery, Shahriar ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOCHEMISTRY; MOLECULES; PROTEINS;

ALLOSTERIC EFFECT; ALLOSTERIC SITE; ANTIBIOTIC RESISTANCE; CONFORMATIONAL CHANGE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PENICILLIN-BINDING PROTEINS; RESISTANCE TO ANTIBIOTICS; X-RAY STRUCTURE;

ANTIBIOTICS;

CEFTAROLINE; PENICILLIN BINDING PROTEIN 2A; ANTIINFECTIVE AGENT; CEPHALOSPORIN DERIVATIVE; PENICILLIN BINDING PROTEIN;

ALLOSTERISM; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; BIOSYNTHESIS; CELL WALL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECTS; GENETICS; MUTATION; PHYSIOLOGY; PROTEIN CONFORMATION; X RAY DIFFRACTION;

ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; DRUG RESISTANCE, BACTERIAL; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PENICILLIN-BINDING PROTEINS; PROTEIN CONFORMATION; X-RAY DIFFRACTION;

EID: 84904409291     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5030657     Document Type: Article

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