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Volumn 39, Issue 2, 2015, Pages 239-250

Changes in the Methylation Status of DAT, SERT, and MeCP2 Gene Promoters in the Blood Cell in Families Exposed to Alcohol During the Periconceptional Period

Author keywords

Alcohol; Dopamine Transporter; Gene Promoter Methylation; Methyl CpG Binding Protein 2; Serotonin Transporter

Indexed keywords

ALCOHOL; DOPAMINE TRANSPORTER; GENOMIC DNA; METHYL CPG BINDING PROTEIN 2; SEROTONIN TRANSPORTER; MECP2 PROTEIN, HUMAN; SLC6A3 PROTEIN, HUMAN; SLC6A4 PROTEIN, HUMAN;

EID: 84922702822     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12635     Document Type: Article
Times cited : (20)

References (55)
  • 2
    • 0037280319 scopus 로고    scopus 로고
    • Elevated methyl-CpG-binding protein 2 expression is acquired during postnatal human brain development and is correlated with alternative polyadenylation
    • Balmer D, Goldstine J, Rao YM, LaSalle JM (2003) Elevated methyl-CpG-binding protein 2 expression is acquired during postnatal human brain development and is correlated with alternative polyadenylation. J Mol Med (Berl) 81:61-68.
    • (2003) J Mol Med (Berl) , vol.81 , pp. 61-68
    • Balmer, D.1    Goldstine, J.2    Rao, Y.M.3    LaSalle, J.M.4
  • 3
    • 84872500748 scopus 로고    scopus 로고
    • Ethanol-induced Htr3a promoter methylation changes in mouse blood and brain
    • Barker JM, Zhang Y, Wang F, Taylor JR, Zhang H (2013) Ethanol-induced Htr3a promoter methylation changes in mouse blood and brain. Alcohol Clin Exp Res 37:E101-E107.
    • (2013) Alcohol Clin Exp Res , vol.37 , pp. E101-E107
    • Barker, J.M.1    Zhang, Y.2    Wang, F.3    Taylor, J.R.4    Zhang, H.5
  • 4
    • 33645368048 scopus 로고    scopus 로고
    • Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence
    • Bleich S, Lenz B, Zeigenbein M, Beutler S, Frieling H, Kornhuber J, Bonsch D (2006) Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence. Alcohol Clin Exp Res 30:587-591.
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 587-591
    • Bleich, S.1    Lenz, B.2    Zeigenbein, M.3    Beutler, S.4    Frieling, H.5    Kornhuber, J.6    Bonsch, D.7
  • 5
    • 13844250333 scopus 로고    scopus 로고
    • DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism
    • Bönsch D, Lenz B, Kornhuber J, Bleich S (2005) DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. NeuroReport 16:167-170.
    • (2005) NeuroReport , vol.16 , pp. 167-170
    • Bönsch, D.1    Lenz, B.2    Kornhuber, J.3    Bleich, S.4
  • 6
    • 0025135501 scopus 로고
    • Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure
    • Bonthius DJ, West Jr. (1990) Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure. Alcohol Clin Exp Res 14:107-118.
    • (1990) Alcohol Clin Exp Res , vol.14 , pp. 107-118
    • Bonthius, D.J.1    West, J.R.2
  • 7
    • 0029054038 scopus 로고
    • Serotonin potentiates ethanol-induced excitation of ventral tegmental area neurons in brain slices from three different rat strains
    • Brodie MS, Trifunovic RD, Shefner SA (1995) Serotonin potentiates ethanol-induced excitation of ventral tegmental area neurons in brain slices from three different rat strains. J Pharmacol Exp Ther 273:1139-1146.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 1139-1146
    • Brodie, M.S.1    Trifunovic, R.D.2    Shefner, S.A.3
  • 10
    • 0030296435 scopus 로고    scopus 로고
    • Serotonin-3 receptor and ethanol-stimulated somatodendritic dopamine release
    • Campbell AD, Kohl RR, McBride WJ (1996) Serotonin-3 receptor and ethanol-stimulated somatodendritic dopamine release. Alcohol 13:569-574.
    • (1996) Alcohol , vol.13 , pp. 569-574
    • Campbell, A.D.1    Kohl, R.R.2    McBride, W.J.3
  • 12
    • 0038515241 scopus 로고    scopus 로고
    • Dopamine transporter density in the basal ganglia assessed with [1231]IPT SPET in children with attention deficit hyperactivity disorder
    • Cheon KA, Ryu YH, Kim YK, Namkoon K, Kim CH, Lee JD (2003) Dopamine transporter density in the basal ganglia assessed with [1231]IPT SPET in children with attention deficit hyperactivity disorder. Eur J Nucl Med Mol Imaging 30:306-311.
    • (2003) Eur J Nucl Med Mol Imaging , vol.30 , pp. 306-311
    • Cheon, K.A.1    Ryu, Y.H.2    Kim, Y.K.3    Namkoon, K.4    Kim, C.H.5    Lee, J.D.6
  • 13
    • 0025258447 scopus 로고
    • Influence of chronic alcohol administration on representative indices of puberty and sexual maturation in male rats and the development of their progeny
    • Cicero TJ, Adams ML, O'Connor L, Nock B, Meyer ER, Wozniak D (1990) Influence of chronic alcohol administration on representative indices of puberty and sexual maturation in male rats and the development of their progeny. J Pharmacol Exp Ther 255:707-715.
    • (1990) J Pharmacol Exp Ther , vol.255 , pp. 707-715
    • Cicero, T.J.1    Adams, M.L.2    O'Connor, L.3    Nock, B.4    Meyer, E.R.5    Wozniak, D.6
  • 14
    • 0035119045 scopus 로고    scopus 로고
    • Third trimester binge ethanol exposure results in fetal hypercapnea and academia but not hypoxemia in pregnant sheep
    • Cudd TA, Chen WJ, Parnell SE, West Jr. (2001) Third trimester binge ethanol exposure results in fetal hypercapnea and academia but not hypoxemia in pregnant sheep. Alcohol Clin Exp Res 25:269-276.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 269-276
    • Cudd, T.A.1    Chen, W.J.2    Parnell, S.E.3    West, J.R.4
  • 15
    • 77957880665 scopus 로고    scopus 로고
    • Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth
    • Devlin AM, Brain U, Austin J, Oberlander TF (2010) Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS One 5:e12201-e12208.
    • (2010) PLoS One , vol.5 , pp. e12201-e12208
    • Devlin, A.M.1    Brain, U.2    Austin, J.3    Oberlander, T.F.4
  • 17
    • 67651121684 scopus 로고    scopus 로고
    • Candidate gene studies of ADHD: a meta-analytic review
    • Gizer IR, Ficks C, Waldman ID (2009) Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126:51-90.
    • (2009) Hum Genet , vol.126 , pp. 51-90
    • Gizer, I.R.1    Ficks, C.2    Waldman, I.D.3
  • 18
    • 0033842481 scopus 로고    scopus 로고
    • The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving
    • Grace AA (2000) The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction 95(Suppl 2):S119-S128.
    • (2000) Addiction , vol.95 , pp. S119-S128
    • Grace, A.A.1
  • 19
    • 58149353008 scopus 로고    scopus 로고
    • Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving
    • Hillemacher T, Frieling H, Hartl T, Wilhelm J, Kornhuber J, Bleich S (2009a) Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving. J Psychiatr Res 43:388-392.
    • (2009) J Psychiatr Res , vol.43 , pp. 388-392
    • Hillemacher, T.1    Frieling, H.2    Hartl, T.3    Wilhelm, J.4    Kornhuber, J.5    Bleich, S.6
  • 22
    • 33745872563 scopus 로고    scopus 로고
    • Effect of moderate ethanol dose on dopamine uptake in rat nucleus accumbens in vivo
    • Jones SR, Mathews TA, Budygin EA (2006) Effect of moderate ethanol dose on dopamine uptake in rat nucleus accumbens in vivo. Synapse 60:251-255.
    • (2006) Synapse , vol.60 , pp. 251-255
    • Jones, S.R.1    Mathews, T.A.2    Budygin, E.A.3
  • 23
    • 0029028444 scopus 로고
    • The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism
    • Kendler KS, Walters EE, Neale MC, Kessler RC, Heath AC, Eaves LJ (1995) The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Arch Gen Psychiatry 52:374-383.
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 374-383
    • Kendler, K.S.1    Walters, E.E.2    Neale, M.C.3    Kessler, R.C.4    Heath, A.C.5    Eaves, L.J.6
  • 24
    • 0029161168 scopus 로고
    • Effect of ethanol on extracellular dopamine in the nucleus accumbens of alcohol-preferring AA and alcohol-avoiding ANA rats
    • Kiianmaa K, Nurmi M, Nykänen I, Sinclair JD (1995) Effect of ethanol on extracellular dopamine in the nucleus accumbens of alcohol-preferring AA and alcohol-avoiding ANA rats. Pharmacol Biochem Behav 52:29-34.
    • (1995) Pharmacol Biochem Behav , vol.52 , pp. 29-34
    • Kiianmaa, K.1    Nurmi, M.2    Nykänen, I.3    Sinclair, J.D.4
  • 26
    • 7244243971 scopus 로고    scopus 로고
    • MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions
    • Kishi N, Macklis JD (2004) MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol Cell Neurosci 27:306-321.
    • (2004) Mol Cell Neurosci , vol.27 , pp. 306-321
    • Kishi, N.1    Macklis, J.D.2
  • 28
    • 0028110689 scopus 로고
    • Serotonin and alcohol intake, abuse, and dependence: clinical evidence
    • LeMarquand D, Pihl RO, Benkelfat C (1994a) Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biol Psychiatry 36:326-337.
    • (1994) Biol Psychiatry , vol.36 , pp. 326-337
    • LeMarquand, D.1    Pihl, R.O.2    Benkelfat, C.3
  • 29
    • 0028094594 scopus 로고
    • Serotonin and alcohol intake, abuse, and dependence: findings of animal studies
    • LeMarquand D, Pihl RO, Benkelfat C (1994b) Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biol Psychiatry 36:395-421.
    • (1994) Biol Psychiatry , vol.36 , pp. 395-421
    • LeMarquand, D.1    Pihl, R.O.2    Benkelfat, C.3
  • 30
    • 84896718104 scopus 로고    scopus 로고
    • Paternal ethanol exposure and behavioral abnormities in offspring: associated alterations in imprinted gene methylation
    • Liang F, Diao L, Liu J, Jiang N, Zhang J, Wang H, Zhou W, Huang G, Ma D (2014) Paternal ethanol exposure and behavioral abnormities in offspring: associated alterations in imprinted gene methylation. Neuropharmacology 81:126-133.
    • (2014) Neuropharmacology , vol.81 , pp. 126-133
    • Liang, F.1    Diao, L.2    Liu, J.3    Jiang, N.4    Zhang, J.5    Wang, H.6    Zhou, W.7    Huang, G.8    Ma, D.9
  • 31
    • 22244459587 scopus 로고    scopus 로고
    • The role of serotonin in alcohol's effects on the brain
    • Lovinger DM (1999) The role of serotonin in alcohol's effects on the brain. Curr Sep 18:23-28.
    • (1999) Curr Sep , vol.18 , pp. 23-28
    • Lovinger, D.M.1
  • 32
    • 0035748481 scopus 로고    scopus 로고
    • Drinking patterns and alcohol-related birth defects
    • Maier SE, West Jr. (2001) Drinking patterns and alcohol-related birth defects. Alcohol Res Health 25:168-174.
    • (2001) Alcohol Res Health , vol.25 , pp. 168-174
    • Maier, S.E.1    West, J.R.2
  • 33
    • 0037163127 scopus 로고    scopus 로고
    • Ethanol-sensitive sites on the human dopamine transporter
    • Maiya R, Buck KJ, Harris RA, Mayfield RD (2002) Ethanol-sensitive sites on the human dopamine transporter. J Biol Chem 277:30724-30729.
    • (2002) J Biol Chem , vol.277 , pp. 30724-30729
    • Maiya, R.1    Buck, K.J.2    Harris, R.A.3    Mayfield, R.D.4
  • 35
    • 33746476339 scopus 로고    scopus 로고
    • No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics
    • Mathews TA, John CE, Lapa GB, Budygin EA, Jones SR (2006) No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics. Synapse 60:288-294.
    • (2006) Synapse , vol.60 , pp. 288-294
    • Mathews, T.A.1    John, C.E.2    Lapa, G.B.3    Budygin, E.A.4    Jones, S.R.5
  • 36
    • 0035205579 scopus 로고    scopus 로고
    • Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes
    • Mayfield RD, Maiya R, Keller D, Zahniser NR (2001) Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes. J Neurochem 79:1070-1079.
    • (2001) J Neurochem , vol.79 , pp. 1070-1079
    • Mayfield, R.D.1    Maiya, R.2    Keller, D.3    Zahniser, N.R.4
  • 37
    • 0036546636 scopus 로고    scopus 로고
    • Case-control study of attention-deficit hyperactivity disorder and maternal smoking, alcohol use and drug use during pregnancy
    • Mick E, Biederman J, Faraone SV, Sayer J, Kleinman S (2002) Case-control study of attention-deficit hyperactivity disorder and maternal smoking, alcohol use and drug use during pregnancy. J Am Acad Child Adolesc Psychiatry 41:378-385.
    • (2002) J Am Acad Child Adolesc Psychiatry , vol.41 , pp. 378-385
    • Mick, E.1    Biederman, J.2    Faraone, S.V.3    Sayer, J.4    Kleinman, S.5
  • 38
    • 34247095504 scopus 로고    scopus 로고
    • Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MeCP2 promoter methylation
    • Nagarajan RP, Hogart AR, Gwye Y, Martin MR, LaSalle JM (2006) Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MeCP2 promoter methylation. Epigenetics 1:e1-e11.
    • (2006) Epigenetics , vol.1 , pp. e1-e11
    • Nagarajan, R.P.1    Hogart, A.R.2    Gwye, Y.3    Martin, M.R.4    LaSalle, J.M.5
  • 39
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A (1998) Transcriptional repression by methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 40
    • 17144468149 scopus 로고    scopus 로고
    • The impact of intrauterine exposure versus postnatal environment in neurodevelopmental toxicity: long-term neurobehavioral studies in children at risk for developmental disorders
    • Ornoy A (2003) The impact of intrauterine exposure versus postnatal environment in neurodevelopmental toxicity: long-term neurobehavioral studies in children at risk for developmental disorders. Toxicol Lett 140-141:171-181.
    • (2003) Toxicol Lett , vol.140-141 , pp. 171-181
    • Ornoy, A.1
  • 41
    • 69249083264 scopus 로고    scopus 로고
    • Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG-DMR in male gametes: implications for fetal alcohol spectrum disorders
    • Ouko LA, Shantikumar K, Knezovich J, Haycock P, Schnugh DJ, Ramsay M (2009) Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG-DMR in male gametes: implications for fetal alcohol spectrum disorders. Alcohol Clin Exp Res 33:1615-1627.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 1615-1627
    • Ouko, L.A.1    Shantikumar, K.2    Knezovich, J.3    Haycock, P.4    Schnugh, D.J.5    Ramsay, M.6
  • 42
    • 79960942415 scopus 로고    scopus 로고
    • Epigenetic changes of serotonin transporter in the patients with alcohol dependence: methylation of an serotonin transporter promoter CpG island
    • Park BY, Lee BC, Jung KH, Jung MH, Park BL, Chai YG, Choi IG (2011) Epigenetic changes of serotonin transporter in the patients with alcohol dependence: methylation of an serotonin transporter promoter CpG island. Psychiatry Investig 8:130-133.
    • (2011) Psychiatry Investig , vol.8 , pp. 130-133
    • Park, B.Y.1    Lee, B.C.2    Jung, K.H.3    Jung, M.H.4    Park, B.L.5    Chai, Y.G.6    Choi, I.G.7
  • 43
    • 33645080930 scopus 로고    scopus 로고
    • Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice
    • Pelka GJ, Watson CM, Radziewic T, Hayward M, Lahooti H, Christodoulou J, Tam PP (2006) Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain 129:887-898.
    • (2006) Brain , vol.129 , pp. 887-898
    • Pelka, G.J.1    Watson, C.M.2    Radziewic, T.3    Hayward, M.4    Lahooti, H.5    Christodoulou, J.6    Tam, P.P.7
  • 45
    • 84865108324 scopus 로고    scopus 로고
    • Vascular effects of maternal alcohol consumption
    • Ramadoss J, Magness R (2012) Vascular effects of maternal alcohol consumption. Am J Physiol Heart Circ Physiol 303:H414-H421.
    • (2012) Am J Physiol Heart Circ Physiol , vol.303 , pp. H414-H421
    • Ramadoss, J.1    Magness, R.2
  • 48
    • 0017375632 scopus 로고
    • Distribution of cardiac output in ovine pregnancy
    • Rosenfeld CR (1977) Distribution of cardiac output in ovine pregnancy. Am J Physiol Heart Circ Physiol 232:H231-H235.
    • (1977) Am J Physiol Heart Circ Physiol , vol.232 , pp. H231-H235
    • Rosenfeld, C.R.1
  • 49
    • 0038731300 scopus 로고    scopus 로고
    • Chloral hydrate and ethanol, but not urethane, alter the clearance of exogenous dopamine recorded by chronoamperometry in striatum of unrestrained rats
    • Sabeti J, Gerhardt GA, Zahniser NR (2003) Chloral hydrate and ethanol, but not urethane, alter the clearance of exogenous dopamine recorded by chronoamperometry in striatum of unrestrained rats. Neurosci Lett 343:9-12.
    • (2003) Neurosci Lett , vol.343 , pp. 9-12
    • Sabeti, J.1    Gerhardt, G.A.2    Zahniser, N.R.3
  • 50
    • 78349279582 scopus 로고    scopus 로고
    • Expression of serotonin transporter in mice with ethanol physical dependency
    • Shibasaki M, Inoue M, Kurokawa K, Ogou S, Ohkuma S (2010) Expression of serotonin transporter in mice with ethanol physical dependency. J Pharmacol Sci 114:234-237.
    • (2010) J Pharmacol Sci , vol.114 , pp. 234-237
    • Shibasaki, M.1    Inoue, M.2    Kurokawa, K.3    Ogou, S.4    Ohkuma, S.5
  • 53
    • 0025196919 scopus 로고
    • Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine
    • Wozniak KM, Pert A, Linnoila M (1990) Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine. Eur J Pharmacol 187:287-289.
    • (1990) Eur J Pharmacol , vol.187 , pp. 287-289
    • Wozniak, K.M.1    Pert, A.2    Linnoila, M.3
  • 54
    • 4143072407 scopus 로고    scopus 로고
    • Association of norepinephrine transporter gene with methylphenidate response
    • Yang L, Wang YF, Li J, Faraone SV (2004) Association of norepinephrine transporter gene with methylphenidate response. J Am Acad Child Adolesc Psychiatry 43:1154-1158.
    • (2004) J Am Acad Child Adolesc Psychiatry , vol.43 , pp. 1154-1158
    • Yang, L.1    Wang, Y.F.2    Li, J.3    Faraone, S.V.4


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