Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes

Journal of Neurochemistry

Volumn 79, Issue 5, 2001, Pages 1070-1079

  Dayne Mayfield, R ^a   Maiya, Rajani ^a   Keller, Denise ^a   Zahniser, Nancy R ^b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Alcohol; DAT; Dopamine transporter; Ethanol; Substrate translocation; Trafficking

Indexed keywords

4 AMINOBUTYRIC ACID; ALCOHOL; DOPAMINE; DOPAMINE TRANSPORTER;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DOPAMINE UPTAKE; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; ELECTROPHYSIOLOGY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; ION CONDUCTANCE; MEMBRANE POTENTIAL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; CARRIER PROTEINS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; ETHANOL; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; HUMANS; KINETICS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; OOCYTES; ORGANIC ANION TRANSPORTERS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, CELL SURFACE; RNA; XENOPUS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0035205579     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00656.x     Document Type: Article

References (59)

1. Neurotransmitter transporters: Recent progress
2. A transient calcium-dependent chloride current in the immature Xenopus oocyte
3. Neurotransmitter transporters: Regulators of function and functional regulation
4. Regulation of gamma-aminobutyric acid (GABA) transporters by extracellular GABA
5. The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices
6. Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro
7. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats
8. Structure and function of the dopamine transporter
9. Voluntary alcohol drinking increases brain dopamine metabolism in rats
10. Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters
11. Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: Electrophysiological and biochemical evidence
12. Release of dopamine via the human transporter
13. Differential effect of acute and chronic ethanol on dopamine metabolism in frontal cortex, caudate nucleus and substantia nigra
14. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia
15. Outflow and overflow of picogram levels of endogenous dopamine and DOPAC from rat striatal slices: Improved methodology for studies of stimulus-evoked release and metabolism
16. Molecular characterization of the dopamine transporter
17. Attenuation of pulsatile changes in the density of striatal [3H]GBR-12935 binding sites during chronic ethanol consumption
18. Bidirectional changes in striatal D1-dopamine receptor density during chronic ethanol intake
19. Fewer dopamine transporter receptors in the pre-frontal cortex of cocaine users
20. Effects of ethanol in vitro and in vivo on the release of endogenous catecholamines from specific regions of rat brain
21. Alterations in dopamine metabolism by intrapetitoneal ethanol in rats selected for high and low ethanol preference: A 3-methoxytyramine study
22. The role of mesoaccumbens pallidal circuitry in novelty-induced behavioral activation
23. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol
24. Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: Cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites
25. Effect of ethanol on extracellular dopamine in the nucleus accumbens of alcohol-preferring AA and alcohol-avoiding ANA rats
26. Prolonged ethanol intake increases D2 dopamine receptor expression in the rat brain
27. Ethanol and negative feedback regulation of mesolimbic dopamine release in rats
28. Neuroscience of addiction
29. A receptor function by general anesthetics and alcohols
30. Functional regulation of gamma-aminobutyric acid transporters by direct tyrosine phosphorylation
31. Ethanol inhibits the uptake of exogenous norepinephrine from the extracellular space of the rat cerebellum
32. Altered dopamine transporter densities in alcohol-preferring vervet monkeys
33. Dopamine D (2) receptor regulation of the dopamine transporter expressed in Xenopus laevis oocytes is voltage-independent
34. Membrane trafficking regulates the activity of the human dopamine transporter
35. Ethanol and functional tolerance: Interactions with pimozide and clonidine
36. Alterations in dopaminergic function after subacute ethanol administration
37. Differential effects of ethanol on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters
38. Dopamine transporter gene polymorphisms are not associated with polysubstance abuse
39. Effect of ethanol on dopamine synthesis in rat striatal synaptosomes
40. Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter
41. Cationic and anionic requirements for the binding of 2 beta-carbomethoxy-3 beta-(4-fluorophenyl) [3H]tropane to the dopamine uptake carrier
42. The effects of local application of ethanol in the n. accumbens on dopamine overflow and clearance
43. Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium
44. Modification of alcohol withdrawal by the a (9) allele of the dopamine transporter gene
45. Molecular mechanisms of drug reinforcement and addiction
46. Acute withdrawal after repeated ethanol treatment reduces the number of spontaneously active dopaminergic neurons in the ventral tegmental area
47. Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter
48. Regulation of glutamate uptake in astrocytes continuously exposed to ethanol
49. Multiple ionic conductances of the human dopamine transporter: The actions of dopamine and psychostimulants
50. Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics
51. Transporter explosion: Update on uptake
52. Effects of ethanol on striatal dopamine overflow and clearance: An in vivo electrochemical study
53. Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: Genetic and motivational determinants
54. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats
55. Ethanol-induced increases in dopamine extracellular concentration in rat nucleus accumbens are accounted for by increased release and not uptake inhibition
56. Comparison of local and systemic ethanol effects on extracellular dopamine concentration in rat nucleus accumbens by microdialysis
57. Ethanol enhances the release of dopamine and serotonin in the nucleus accumbens of HAD and LAD lines of rats
58. Regulation of the functional activity of the human dopamine transporter by protein kinase C
59. Activation of protein kinase C inhibits uptake, currents and binding associated with the human dopamine transporter expressed in Xenopus oocytes