메뉴 건너뛰기




Volumn 9, Issue 1, 2013, Pages 6-11

MG132, a proteasome inhibitor, induces apoptosis in tumor cells

Author keywords

Anti tumor; Apoptosis; MG132; Proteasome inhibitor; Tumor cells

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CELL CYCLE PROTEIN; CYCLIN A; CYCLIN B; CYSTEINE PROTEINASE; HEAT SHOCK TRANSCRIPTION FACTOR 1; I KAPPA B; I KAPPA B ALPHA; MYC PROTEIN; PROTEASOME INHIBITOR; PROTEIN C FOS; PROTEIN C JUN; PROTEIN P21; PROTEIN P27; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR HIFI; TRANSCRIPTION FACTOR ICER; TRANSCRIPTION FACTOR YYI; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

EID: 84874115018     PISSN: 17437555     EISSN: 17437563     Source Type: Journal    
DOI: 10.1111/j.1743-7563.2012.01535.x     Document Type: Review
Times cited : (161)

References (29)
  • 1
    • 33847082149 scopus 로고    scopus 로고
    • Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding
    • Dowell JD, Tsai S-C etal. Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding. Biochim Biophys Acta 2007; 1773: 358-8.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 358-358
    • Dowell, J.D.1    Tsai, S.-C.2
  • 2
    • 84874113174 scopus 로고    scopus 로고
    • Advancement of research into proteasome inhibitors in overcoming multidrug resistance of tumor
    • Yi W, Xu B, Li M. Advancement of research into proteasome inhibitors in overcoming multidrug resistance of tumor. International Journal of Pharmaceutical Research 2007; 34: 87-5.
    • (2007) International Journal of Pharmaceutical Research , vol.34 , pp. 87-85
    • Yi, W.1    Xu, B.2    Li, M.3
  • 3
    • 52049100130 scopus 로고    scopus 로고
    • The proteasome inhibitor MG132 induces nuclear translocation of erythroid transcription factor Nrf2 and cyclooxygenase-2 expression in human vascular endothelial cells
    • Sahni SK, Rydkina E, Sahni A. The proteasome inhibitor MG132 induces nuclear translocation of erythroid transcription factor Nrf2 and cyclooxygenase-2 expression in human vascular endothelial cells. Thromb Res 2008; 122: 820-5.
    • (2008) Thromb Res , vol.122 , pp. 820-825
    • Sahni, S.K.1    Rydkina, E.2    Sahni, A.3
  • 4
    • 84878905954 scopus 로고    scopus 로고
    • Exposure of Lemna minor to arsenite: expression levels of the components and intermediates of the ubiquitin/proteasome pathway
    • Santos C, Gaspar M, Caeiro A, Branco-Price C, Teixeira A, Ferreira RB. Exposure of Lemna minor to arsenite: expression levels of the components and intermediates of the ubiquitin/proteasome pathway. Plant Cell Physiol 2006; 47: 1262-73.
    • (2006) Plant Cell Physiol , vol.47 , pp. 1262-1273
    • Santos, C.1    Gaspar, M.2    Caeiro, A.3    Branco-Price, C.4    Teixeira, A.5    Ferreira, R.B.6
  • 5
    • 33646406554 scopus 로고    scopus 로고
    • Celastrol, a triterpene extracted from the Chinese "thunder of god vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    • Yang H, Chen D, Cui QC, Yuan X, Dou QP. Celastrol, a triterpene extracted from the Chinese "thunder of god vine, " is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 2005; 66: 4758-65.
    • (2005) Cancer Res , vol.66 , pp. 4758-4765
    • Yang, H.1    Chen, D.2    Cui, Q.C.3    Yuan, X.4    Dou, Q.P.5
  • 6
    • 77952956912 scopus 로고    scopus 로고
    • MG132, a proteasome inhibitor decreased the growth of Calu-6 lung cancer cells via apoptosis and GSH depletion
    • Han YH, Park WH. MG132, a proteasome inhibitor decreased the growth of Calu-6 lung cancer cells via apoptosis and GSH depletion. Toxicol In Vitro 2010; 24: 1237-5.
    • (2010) Toxicol In Vitro , vol.24 , pp. 1237-1235
    • Han, Y.H.1    Park, W.H.2
  • 7
    • 0031034160 scopus 로고    scopus 로고
    • Activation of the cell death program by inhibition of proteasome function
    • Drexler HCA. Activation of the cell death program by inhibition of proteasome function. Proc Natl Acad Sci U S A 1997; 94: 855-60.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 855-860
    • Drexler, H.C.A.1
  • 8
    • 3242676986 scopus 로고    scopus 로고
    • Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents
    • Bang JH, Han ES, Lim I, Lee CS. Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem Pharmacol 2004; 68: 659-7.
    • (2004) Biochem Pharmacol , vol.68 , pp. 659-657
    • Bang, J.H.1    Han, E.S.2    Lim, I.3    Lee, C.S.4
  • 9
    • 30144442233 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status
    • Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E, Colomer D. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 2006; 107: 257-7.
    • (2006) Blood , vol.107 , pp. 257-257
    • Perez-Galan, P.1    Roue, G.2    Villamor, N.3    Montserrat, E.4    Campo, E.5    Colomer, D.6
  • 10
    • 1642286961 scopus 로고    scopus 로고
    • The role of ROS and RNS in regulating life and death of blood monocytes
    • Baran CP, Zeigler MM, Tridandapani S, Marsh CB. The role of ROS and RNS in regulating life and death of blood monocytes. Curr Pharm Des 2004; 10: 855-11.
    • (2004) Curr Pharm Des , vol.10 , pp. 855-811
    • Baran, C.P.1    Zeigler, M.M.2    Tridandapani, S.3    Marsh, C.B.4
  • 11
    • 0141706672 scopus 로고    scopus 로고
    • Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells
    • Ling YH, Liebes L, Zou Y, Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem 2003; 278: 33714-9.
    • (2003) J Biol Chem , vol.278 , pp. 33714-33719
    • Ling, Y.H.1    Liebes, L.2    Zou, Y.3    Perez-Soler, R.4
  • 12
    • 0027233448 scopus 로고
    • Signal transduction via the MAP kinases: proceed at your own RSK
    • Blenis J. Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci U S A 1993; 90: 5889-3.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5889-5883
    • Blenis, J.1
  • 13
    • 74149085251 scopus 로고    scopus 로고
    • The effects of MAPK inhibitors on a proteasome inhibitor, MG132-induced HeLa cell death in relation to reactive oxygen species and glutathione
    • Han YH, Park WH. The effects of MAPK inhibitors on a proteasome inhibitor, MG132-induced HeLa cell death in relation to reactive oxygen species and glutathione. Toxicol Lett 2010; 192: 134-6.
    • (2010) Toxicol Lett , vol.192 , pp. 134-136
    • Han, Y.H.1    Park, W.H.2
  • 14
    • 1942436864 scopus 로고    scopus 로고
    • Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells
    • Qin H, Huang Y, Sheikh MS. Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells. Oncogene 2004; 23: 2554-4.
    • (2004) Oncogene , vol.23 , pp. 2554-2554
    • Qin, H.1    Huang, Y.2    Sheikh, M.S.3
  • 16
    • 0031414749 scopus 로고    scopus 로고
    • The novel receptor TRAIL-R4 induces NF-kappa B and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain
    • Degli-Esposti MA, Dougall WC, Smolak PJ, Waugh JY, Smith CA, Goodwin RG. The novel receptor TRAIL-R4 induces NF-kappa B and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 1997; 7: 813-7.
    • (1997) Immunity , vol.7 , pp. 813-817
    • Degli-Esposti, M.A.1    Dougall, W.C.2    Smolak, P.J.3    Waugh, J.Y.4    Smith, C.A.5    Goodwin, R.G.6
  • 17
    • 0029683566 scopus 로고    scopus 로고
    • The transcriptional regulation of heat shock genes: a plethora of heat shock factors and regulatory conditions
    • Morimoto RI, Kroeger PE, Cotto JJ. The transcriptional regulation of heat shock genes: a plethora of heat shock factors and regulatory conditions. EXS 1996; 77: 139-24.
    • (1996) EXS , vol.77 , pp. 139-124
    • Morimoto, R.I.1    Kroeger, P.E.2    Cotto, J.J.3
  • 18
    • 0032571397 scopus 로고    scopus 로고
    • Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis
    • McMillan DR, Xiao X, Shao L, Graves K, Benjamin IJ. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem 1998; 273: 7523-5.
    • (1998) J Biol Chem , vol.273 , pp. 7523-7525
    • McMillan, D.R.1    Xiao, X.2    Shao, L.3    Graves, K.4    Benjamin, I.J.5
  • 19
    • 0033595750 scopus 로고    scopus 로고
    • Proteasome inhibitors lactacystin and MG132 inhibit the dephosphorylation of HSF1 after heat shock and suppress thermal induction of heat shock gene expression
    • Kim D, Li GC. Proteasome inhibitors lactacystin and MG132 inhibit the dephosphorylation of HSF1 after heat shock and suppress thermal induction of heat shock gene expression. Biochem Biophys Res Commun 1999; 264: 352-6.
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 352-356
    • Kim, D.1    Li, G.C.2
  • 20
    • 0027159173 scopus 로고
    • Mol activation of drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition
    • Westwood JT, Wu C. Mol activation of drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition. Cell Biol 1993; 13: 3481-5.
    • (1993) Cell Biol , vol.13 , pp. 3481-3485
    • Westwood, J.T.1    Wu, C.2
  • 21
    • 0033596127 scopus 로고    scopus 로고
    • Control of apoptosis by Rel/NF-κB transcription factors
    • Barkett M, Gilmore TD. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 1999; 18: 6910-14.
    • (1999) Oncogene , vol.18 , pp. 6910-6914
    • Barkett, M.1    Gilmore, T.D.2
  • 23
    • 8344260568 scopus 로고    scopus 로고
    • Ferritin heavy chain upregulation by NF-kappa B inhibits TNF alpha-induced apoptosis by suppressing reactive oxygen species
    • Pham CG, Bubici C, Zazzeroni F etal. Ferritin heavy chain upregulation by NF-kappa B inhibits TNF alpha-induced apoptosis by suppressing reactive oxygen species. Cell 2004; 119: 529-13.
    • (2004) Cell , vol.119 , pp. 529-513
    • Pham, C.G.1    Bubici, C.2    Zazzeroni, F.3
  • 24
    • 0034651739 scopus 로고    scopus 로고
    • Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells
    • Furman RR, Asgary Z, Mascarenhas JO, Liou HC, Schattner EJ. Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells. J Immunol 2000; 164: 2200-6.
    • (2000) J Immunol , vol.164 , pp. 2200-2206
    • Furman, R.R.1    Asgary, Z.2    Mascarenhas, J.O.3    Liou, H.C.4    Schattner, E.J.5
  • 25
    • 33645116785 scopus 로고    scopus 로고
    • NF-κB activation as a pathological mechanism of septic shock and inflammation
    • Liu SF, Malik AB. NF-κB activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 2006; 290: L622-45.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Liu, S.F.1    Malik, A.B.2
  • 26
    • 0029093605 scopus 로고
    • Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development
    • PAN HC, GRIEP AE. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development. Genes Dev 1995; 9: 2157-12.
    • (1995) Genes Dev , vol.9 , pp. 2157-2112
    • PAN, H.C.1    Griep, A.E.2
  • 27
    • 11844294713 scopus 로고    scopus 로고
    • Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis
    • Erdal H, Berndtsson M, Castro J, Brunk U, Shoshan MC, Linder S. Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proc Natl Acad Sci U S A 2005; 102: 192-7.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 192-197
    • Erdal, H.1    Berndtsson, M.2    Castro, J.3    Brunk, U.4    Shoshan, M.C.5    Linder, S.6
  • 28
    • 33646407310 scopus 로고    scopus 로고
    • MG132 induced apoptosis is associated with p53-independent induction of pro-apoptotic Noxa and transcriptional activity of beta-catenin
    • Jullig M, Zhang WV, Ferreira A, Stott NS. MG132 induced apoptosis is associated with p53-independent induction of pro-apoptotic Noxa and transcriptional activity of beta-catenin. Apoptosis 2006; 11: 627-41.
    • (2006) Apoptosis , vol.11 , pp. 627-641
    • Jullig, M.1    Zhang, W.V.2    Ferreira, A.3    Stott, N.S.4
  • 29
    • 79251473091 scopus 로고    scopus 로고
    • Proteasome inhibitors induce p53-independent apoptosis in human cancer cells
    • Pandit B, Gartel AL. Proteasome inhibitors induce p53-independent apoptosis in human cancer cells. Am J Pathol 2011; 178: 355-5.
    • (2011) Am J Pathol , vol.178 , pp. 355-355
    • Pandit, B.1    Gartel, A.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.