Natural killer T cells play a necessary role in modulating of immune-mediated liver injury by gut microbiota

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Chen, Jianing ^a   Wei, Yingfeng ^a   He, Jianqin ^a   Cui, Guangying ^a   Zhu, Yunan ^a   Lu, Chong ^a   Ding, Yulong ^a   Xue, Rufeng ^b,c   Bai, Li ^b,c   Uede, Toshimitsu ^d   Li, Lanjuan ^a   Diao, Hongyan ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROBIOTIC AGENT;

ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; DENDRITIC CELL; FEMALE; HEPATITIS; IMMUNOLOGY; IMMUNOMODULATION; INTESTINE; MICROFLORA; MOUSE; NATURAL KILLER T CELL; PATHOLOGY; TREATMENT OUTCOME;

ANIMALS; DENDRITIC CELLS; FEMALE; HEPATITIS; IMMUNOMODULATION; INTESTINES; MICE; MICE, INBRED C57BL; MICROBIOTA; MODELS, IMMUNOLOGICAL; NATURAL KILLER T-CELLS; PROBIOTICS; TREATMENT OUTCOME;

EID: 84922664549     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep07259     Document Type: Article

References (70)

1. Diao, H., et al. Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity 21, 539-550 (2004
2. Wilson, M. T., et al. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc Natl Acad Sci U S A 100, 10913-10918 (2003
3. Miele, L., et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49, 1877-1887 (2009
4. Hartmann, P., Haimerl, M., Mazagova, M., Brenner, D. A. & Schnabl, B. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Gastroenterology 143, 1330-1340 e1331 (2012
5. De Minicis, S., et al. Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice. Hepatology 59, 1738-1749 (2014
6. Backhed, F., et al. The gut microbiota as an environmental factor that regulates fat storage. P Natl Acad Sci USA 101, 15718-15723 (2004
7. Cryan, J. F. & O'Mahony, S. M. The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol Motil 23, 187-192 (2011
8. Round, J. L., O'Connell, R. M. & Mazmanian, S. K. Coordination of tolerogenic immune responses by the commensal microbiota. Journal of Autoimmunity 34, J220-J225 (2010
9. Celaj, S., et al. The microbiota regulates susceptibility to Fas-mediated acute hepatic injury. Laboratory investigation; a journal of technical methods and pathology 94, 938-949 (2014
10. Schnabl, B. & Brenner, D. A. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146, 1513-1524 (2014
11. Zhang, H. L., et al. Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. J Hepatol 57, 803-812 (2012
12. Li, Z., et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37, 343-350 (2003
13. Dapito, D. H., et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21, 504-516 (2012
14. Harada, M., et al. Down-regulation of the invariant Valpha14 antigen receptor in NKT cells upon activation. Int Immunol 16, 241-247 (2004
15. Takeda, K., et al. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci U S A 97, 5498-5503 (2000
16. Park, S. G., et al. T regulatory cells maintain intestinal homeostasis by suppressing gammadelta T cells. Immunity 33, 791-803 (2010
17. Jung, C., Hugot, J. P. & Barreau, F. Peyer's Patches: The Immune Sensors of the Intestine. International journal of inflammation 2010, 823710 (2010
18. Imajo, K., Yoneda, M., Ogawa, Y., Wada, K. & Nakajima, A. Microbiota and nonalcoholic steatohepatitis. Seminars in immunopathology 36, 115-132 (2014
19. Bajaj, J. S., et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications. Journal of hepatology 60, 940-947 (2014
20. Yu, L. X., et al. Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology 52, 1322-1333 (2010
21. Li, Y. T., et al. Effects of gut microflora on hepatic damage after acute liver injury in rats. J Trauma 68, 76-83 (2010
22. Zhang, Z., et al. Large-scale survey of gut microbiota associated with MHE Via 16S rRNA-based pyrosequencing. Am J Gastroenterol 108, 1601-1611 (2013
23. Diao, H., et al. Osteopontin regulates development and function of invariant natural killer T cells. Proc Natl Acad Sci U S A 105, 15884-15889 (2008
24. Sullivan, B. A. & Kronenberg, M. Activation or anergy: NKT cells are stunned by alpha-galactosylceramide. The Journal of clinical investigation 115, 2328-2329 (2005
25. Crispe, I. N. The Liver as a Lymphoid Organ. Annu Rev Immunol 27, 147-163 (2009
26. Gilboa, E. DC-based cancer vaccines. J Clin Invest 117, 1195-1203 (2007
27. Banchereau, J., et al. Immunobiology of dendritic cells. Annu Rev Immunol 18, 767-1 (2000
28. Huang, H., Dawicki, W., Zhang, X., Town, J.& Gordon, J. R. Tolerogenic dendritic cells induce CD41CD25hiFoxp31 regulatory T cell differentiation from CD41CD25-/loFoxp3- effector T cells. J Immunol 185, 5003-5010 (2010
29. Kinnebrew, M. A., et al. Interleukin 23 production by intestinal CD103(1)CD11b(1) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 36, 276-287 (2012
30. Tezuka, H. & Ohteki, T. Regulation of intestinal homeostasis by dendritic cells. Immunol Rev 234, 247-258 (2010
31. Ueta, H., et al. Systemic transmigration of allosensitizing donor dendritic cells to host secondary lymphoid organs after rat liver transplantation. Hepatology 47, 1352-1362 (2008
32. Sallusto, F. DCs: a dual bridge to protective immunity. Nat Immunol 14, 890-891 (2013
33. Mattner, J., et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434, 525-529 (2005
34. Kinjo, Y., et al. Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol 12, 966-U972 (2011
35. Toyabe, S., et al. Requirement of IL-4 and liver NK11 T cells for concanavalin Ainduced hepatic injury in mice. J Immunol 159, 1537-1542 (1997
36. Lin, Y., et al. Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through Toll-like receptor 4. Cancer prevention research (Philadelphia, Pa.) 5, 1090-1102 (2012
37. Diao, H.& Kohanawa, M. Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production. Infection and immunity 73, 3745-3748 (2005
38. Chen, Y., et al. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 54, 562-572 (2011
39. Bartosch, S., Fite, A., Macfarlane, G. T. & McMurdo, M. E. Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota. Applied and environmental microbiology 70, 3575-3581 (2004).
40. Celaj, S., et al. The microbiota regulates susceptibility to Fas-mediated acute hepatic injury. Laboratory investigation; a journal of technical methods and pathology 94, 938-949 (2014
41. Schnabl, B. & Brenner, D. A. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146, 1513-1524 (2014
42. Zhang, H. L., et al. Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. J Hepatol 57, 803-812 (2012
43. Li, Z., et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37, 343-350 (2003
44. Dapito, D. H., et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21, 504-516 (2012
45. Harada, M., et al. Down-regulation of the invariant Valpha14 antigen receptor in NKT cells upon activation. Int Immunol 16, 241-247 (2004
46. Takeda, K., et al. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci U S A 97, 5498-5503 (2000
47. Park, S. G., et al. T regulatory cells maintain intestinal homeostasis by suppressing gammadelta T cells. Immunity 33, 791-803 (2010
48. Jung, C., Hugot, J. P. & Barreau, F. Peyer's Patches: The Immune Sensors of the Intestine. International journal of inflammation 2010, 823710 (2010
49. Imajo, K., Yoneda, M., Ogawa, Y., Wada, K. & Nakajima, A. Microbiota and nonalcoholic steatohepatitis. Seminars in immunopathology 36, 115-132 (2014
50. Bajaj, J. S., et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications. Journal of hepatology 60, 940-947 (2014
51. Yu, L. X., et al. Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology 52, 1322-1333 (2010
52. Li, Y. T., et al. Effects of gut microflora on hepatic damage after acute liver injury in rats. J Trauma 68, 76-83 (2010
53. Zhang, Z., et al. Large-scale survey of gut microbiota associated with MHE Via 16S rRNA-based pyrosequencing. Am J Gastroenterol 108, 1601-1611 (2013
54. Diao, H., et al. Osteopontin regulates development and function of invariant natural killer T cells. Proc Natl Acad Sci U S A 105, 15884-15889 (2008
55. Sullivan, B. A. & Kronenberg, M. Activation or anergy: NKT cells are stunned by alpha-galactosylceramide. The Journal of clinical investigation 115, 2328-2329 (2005
56. Crispe, I. N. The Liver as a Lymphoid Organ. Annu Rev Immunol 27, 147-163 (2009
57. Gilboa, E. DC-based cancer vaccines. J Clin Invest 117, 1195-1203 (2007
58. Banchereau, J., et al. Immunobiology of dendritic cells. Annu Rev Immunol 18, 767-1 (2000
59. Huang, H., Dawicki, W., Zhang, X., Town, J.& Gordon, J. R. Tolerogenic dendritic cells induce CD41CD25hiFoxp31 regulatory T cell differentiation from CD41CD25-/loFoxp3- effector T cells. J Immunol 185, 5003-5010 (2010
60. Kinnebrew, M. A., et al. Interleukin 23 production by intestinal CD103(1)CD11b(1) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 36, 276-287 (2012
61. Tezuka, H. & Ohteki, T. Regulation of intestinal homeostasis by dendritic cells. Immunol Rev 234, 247-258 (2010
62. Ueta, H., et al. Systemic transmigration of allosensitizing donor dendritic cells to host secondary lymphoid organs after rat liver transplantation. Hepatology 47, 1352-1362 (2008
63. Sallusto, F. DCs: a dual bridge to protective immunity. Nat Immunol 14, 890-891 (2013
64. Mattner, J., et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434, 525-529 (2005
65. Kinjo, Y., et al. Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol 12, 966-U972 (2011
66. Toyabe, S., et al. Requirement of IL-4 and liver NK11 T cells for concanavalin Ainduced hepatic injury in mice. J Immunol 159, 1537-1542 (1997
67. Lin, Y., et al. Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through Toll-like receptor 4. Cancer prevention research (Philadelphia, Pa.) 5, 1090-1102 (2012
68. Diao, H.& Kohanawa, M. Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production. Infection and immunity 73, 3745-3748 (2005
69. Chen, Y., et al. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 54, 562-572 (2011
70. Bartosch, S., Fite, A., Macfarlane, G. T. & McMurdo, M. E. Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota. Applied and environmental microbiology 70, 3575-3581 (2004