Polyglutamine-expanded ataxin-3impairslong-term depression in Purkinjeneurons of SCA3 transgenic mouse byinhibiting HAT andimpairing histone acetylation

Brain Research

Volumn 1583, Issue 1, 2014, Pages 220-229

  Chou, An Hsun ^a   Chen, Ying Ling ^b   Hu, Su Huei ^c   Chang, Ya Ming ^c,d   Wang, Hung Li ^a,c,d  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Cerebellar long term depression; Histone acetylation; Histone acetyltransferase; Polyglutamine expanded ataxin 3; Purkinje neuron; Spinocerebellar ataxia type 3

Indexed keywords

ATAXIN 3; BUTYRIC ACID; CALCINEURIN; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE H3; HISTONE H4; MESSENGER RNA; MYOSIN VA; POLYGLUTAMINE; ATXN3 PROTEIN, HUMAN; HISTONE; HISTONE DEACETYLASE INHIBITOR; NERVE PROTEIN; NUCLEAR PROTEIN; PEPTIDE; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CEREBELLUM; CHROMATIN IMMUNOPRECIPITATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE REPRESSION; HISTONE ACETYLATION; LONG TERM DEPRESSION; MEMBRANE STEADY POTENTIAL; MOTOR COORDINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PURKINJE CELL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; GENETICS; MACHADO-JOSEPH DISEASE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; TISSUE CULTURE TECHNIQUE; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT;

MUS; MUS MUSCULUS;

ACETYLATION; ANIMALS; BUTYRIC ACID; CEREBELLUM; DISEASE MODELS, ANIMAL; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; LONG-TERM SYNAPTIC DEPRESSION; MACHADO-JOSEPH DISEASE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PURKINJE CELLS; REPRESSOR PROTEINS; TISSUE CULTURE TECHNIQUES; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84922644566     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.08.019     Document Type: Article

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