Impaired long-term potentiation in the prefrontal cortex of Huntington's disease mouse models: Rescue by D1 dopamine receptor activation

Neurodegenerative Diseases

Volumn 8, Issue 4, 2011, Pages 230-239

  Dallerac G M ^a   Vatsavayai, S C ^a   Cummings, D M ^a   Milnerwood, A J ^a   Peddie, C J ^a   Evans, K A ^a   Walters, S W ^a   Rezaie, P ^a   Hirst, M C ^a   Murphy, K P S J ^a  

^a OPEN UNIVERSITY   (United Kingdom)

Author keywords

CAG triplet repeat; Huntingtin; Long term potentiation; Synaptic plasticity; Synaptopathies

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR STIMULATING AGENT; MUTANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CAG REPEAT; COGNITIVE DEFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; LONG TERM POTENTIATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN LOCALIZATION; WORKING MEMORY;

ANIMALS; DISEASE MODELS, ANIMAL; DOPAMINE AGONISTS; ELECTROPHYSIOLOGY; FEMALE; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; LONG-TERM POTENTIATION; MALE; MICE; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; PREFRONTAL CORTEX; RECEPTORS, DOPAMINE D1; SYNAPTIC TRANSMISSION;

EID: 79955826768     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000322540     Document Type: Article

References (50)

1. Paulson HL, Fischbeck KH: Trinucleotide repeats in neurogenetic disorders. Annu Rev Neurosci 1996; 19: 79-107. (Pubitemid 26080823)
2. Becher MW, Kotzuk JA, Sharp AH, Davies SW, Bates GP, Price DL, Ross CA: Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length. Neurobiol Dis 1998; 4: 387-397. (Pubitemid 28201657)
3. Harper PS: Huntington's Disease. Major Problems in Neurology. Philadelphia, WB Saunders, 1996.
4. Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr: Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol 1985; 44: 559-577. (Pubitemid 16196286)
5. Hedreen JC, Peyser CE, Folstein SE, Ross CA: Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease. Neurosci Lett 1991; 133: 257-261.
6. Foroud T, Siemers E, Kleindorfer D, Bill DJ, Hodes ME, Norton JA, Conneally PM, Christian JC: Cognitive scores in carriers of Huntington's disease gene compared to noncarriers. Ann Neurol 1995; 37: 657-664.
7. Lawrence AD, Hodges JR, Rosser AE, Kershaw A, Ffrench-Constant C, Rubinsztein DC, Robbins TW, Sahakian BJ: Evidence for specific cognitive deficits in preclinical Huntington's disease. Brain 1998; 121: 1329-1341. (Pubitemid 28327409)
8. Thiruvady DR, Georgiou-Karistianis N, Egan GF, Ray S, Sritharan A, Farrow M, Churchyard A, Chua P, Bradshaw JL, Brawn TL, et al: Functional connectivity of the prefrontal cortex in Huntington's disease. J Neurol Neurosurg Psychiatry 2007; 78: 127-133. (Pubitemid 46220207)
9. Snowden JS, Craufurd D, Thompson J, Neary D: Psychomotor, executive, and memory function in preclinical Huntington's disease. J Clin Exp Neuropsychol 2002; 24: 133-145. (Pubitemid 34496862)
10. Lemiere J, Decruyenaere M, Evers-Kiebooms G, Vandenbussche E, Dom R: Cognitive changes in patients with Huntington's disease (HD) and asymptomatic carriers of the HD mutation -A longitudinal follow-up study. J Neurol 2004; 251: 935-942. (Pubitemid 39119311)
11. Goldman-Rakic PS: Architecture of the prefrontal cortex and the central executive. Ann NY Acad Sci 1995; 769: 71-83. (Pubitemid 26075885)
12. Fuster JM: Memory networks in the prefrontal cortex. Prog Brain Res 2000; 122: 309-316. (Pubitemid 30114486)
13. Bylsma FW, Peyser CE, Folstein SE, Folstein MF, Ross C, Brandt J: EEG power spectra in Huntington's disease: clinical and neuropsychological correlates. Neuropsychologia 1994; 32: 137-150. (Pubitemid 24061882)
14. van der Hiele K, Jurgens CK, Vein AA, Reijntjes RH, Witjes-Ane MN, Roos RA, van Dijk G, Middelkoop HA: Memory activation reveals abnormal EEG in preclinical Huntington's disease. Mov Disord 2007; 22: 690-695. (Pubitemid 46800140)
15. Otani S, Daniel H, Roisin MP, Crepel F: Dopaminergic modulation of long-term synaptic plasticity in rat prefrontal neurons. Cereb Cortex 2003; 13: 1251-1256. (Pubitemid 37323001)
16. Williams GV, Castner SA: Under the curve: critical issues for elucidating D 1 receptor function in working memory. Neuroscience 2006; 139: 263-276.
17. Sedvall G, Karlsson P, Lundin A, Anvret M, Suhara T, Halldin C, Farde L: Dopamine D 1 receptor number -A sensitive PET marker for early brain degeneration in Huntington's disease. Eur Arch Psychiatry Clin Neurosci 1994; 243: 249-255. (Pubitemid 24083879)
18. Weeks RA, Piccini P, Harding AE, Brooks DJ: Striatal D 1 and D 2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease. Ann Neurol 1996; 40: 49-54. (Pubitemid 26250142)
19. Pavese N, Andrews TC, Brooks DJ, Ho AK, Rosser AE, Barker RA, Robbins TW, Sahakian BJ, Dunnett SB, Piccini P: Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: a PET study. Brain 2003; 126: 1127-1135. (Pubitemid 36522955)
20. Huntington's Disease Collaborative Research Group: A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993; 72: 971-983.
21. Bates GP, Murphy KPSJ: Mouse models of Huntington's disease; in Bates G, Harper P, Jones L (eds): Huntington's Disease. Oxford, Oxford University Press, 2002, vol 45, pp 397-426.
22. Cummings DM, Milnerwood AJ, Dallerac GM, Brown JY, Vatsavayai SC, Waights V, Hirst MC, Murphy KPSJ: Aberrant cortical plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease. Hum Mol Genet 2006; 15: 2856-2868. (Pubitemid 44446806)
23. Cybulska-Klosowicz A, Mazarakis NK, Van Dellen A, Blakemore C, Hannan AJ, Kossut M: Impaired learning-dependent cortical plasticity in Huntington's disease transgenic mice. Neurobiol Dis 2004; 17: 427-434. (Pubitemid 39574876)
24. Cha JH, Kosinski CM, Kerner JA, Alsdorf SA, Mangiarini L, Davies SW, Penney JB, Bates GP, Young AB: Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene. Proc Natl Acad Sci USA 1998; 95: 6480-6485. (Pubitemid 28249039)
25. Johnson MA, Rajan V, Miller CE, Wightman RM: Dopamine release is severely compromised in the R6/2 mouse model of Huntington's disease. J Neurochem 2006; 97: 737-746.
26. Walker AG, Miller BR, Fritsch JN, Barton SJ, Rebec GV: Altered information processing in the prefrontal cortex of Huntington's disease mouse models. J Neurosci 2008; 28: 8973-8982.
27. Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, et al: Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 1996; 87: 493-506. (Pubitemid 26374323)
28. Vatsavayai SC, Dallerac GM, Milnerwood AJ, Cummings DM, Rezaie P, Murphy KPSJ, Hirst MC: Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset. Brain Res Bull 2007; 72: 103-107.
29. Milnerwood AJ, Cummings DM, Dallerac GM, Brown JY, Vatsavayai SC, Hirst MC, Rezaie P, Murphy KPSJ: Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease. Hum Mol Genet 2006; 15: 1690-1703. (Pubitemid 43904835)
30. Murphy KP, Carter RJ, Lione LA, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ: Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation. J Neurosci 2000; 20: 5115-5123. (Pubitemid 30421714)
31. Milner AJ, Cummings DM, Spencer JP, Murphy KP: Bi-directional plasticity and age-dependent long-term depression at mouse CA3-CA1 hippocampal synapses. Neurosci Lett 2004; 367: 1-5. (Pubitemid 39078772)
32. Huang YY, Simpson E, Kellendonk C, Kandel ER: Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D 1 receptors. Proc Natl Acad Sci USA 2004; 101: 3236-3241. (Pubitemid 38327764)
33. Zucker RS: Changes in the statistics of transmitter release during facilitation. J Physiol 1973; 229: 787-810.
34. Bliss TV, Collingridge GL: A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993; 361: 31-39. (Pubitemid 23020772)
35. Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, et al: A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron 1999; 23: 181-192. (Pubitemid 29262475)
36. Cummings DM, Milnerwood AJ, Dallerac GM, Vatsavayai SC, Hirst MC, Murphy KP: Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease. Brain Res Bull 2007; 72: 103-107. (Pubitemid 46367455)
37. Kung VW, Hassam R, Morton AJ, Jones S: Dopamine-dependent long-term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease. Neuroscience 2007; 146: 1571-1580. (Pubitemid 46783231)
38. Mair RD, Kauer JA: Amphetamine depresses excitatory synaptic transmission at prefrontal cortical layer V synapses. Neuropharmacology 2007; 52: 193-199. (Pubitemid 46039780)
39. Dong Y, Cooper D, Nasif F, Hu XT, White FJ: Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons. J Neurosci 2004; 24: 3077-3085. (Pubitemid 38405755)
40. Sun X, Zhao Y, Wolf ME: Dopamine receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons. J Neurosci 2005; 25: 7342-7351. (Pubitemid 41129806)
41. Cepeda C, Levine MS: Where do you think you are going? The NMDA-D1 receptor trap. Sci STKE 2006; 2006:pe20.
42. Zheng P, Zhang XX, Bunney BS, Shi WX: Opposite modulation of cortical N-methyl-D -aspartate receptor-mediated responses by low and high concentrations of dopamine. Neuroscience 1999; 91: 527-535. (Pubitemid 29193262)
43. Young CE, Yang CR: Dopamine D 1 -like receptor modulates layer-and frequency-specific short-term synaptic plasticity in rat prefrontal cortical neurons. Eur J Neurosci 2005; 21: 3310-3320. (Pubitemid 40961426)
44. Gurden H, Takita M, Jay TM: Essential role of D1 but note D2 receptors in the NMDA receptor-dependent long-term potentiation at hippocampal-prefrontal cortex synapses in vivo. J Neurosci 2000;20:RC106.
45. Cepeda C, Ariano MA, Calvert CR, Flores-Hernandez J, Chandler SH, Leavitt BR, Hayden MR, Levine MS: NMDA receptor function in mouse models of Huntington disease. J Neurosci Res 2001; 66: 525-539. (Pubitemid 33032321)
46. Starling AJ, Andre VM, Cepeda C, de Lima M, Chandler SH, Levine MS: Alterations in N-methyl-D -aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease. J Neurosci Res 2005; 82: 377-386. (Pubitemid 41552488)
47. Andre VM, Cepeda C, Venegas A, Gomez Y, Levine MS: Altered cortical glutamate receptor function in the R6/2 model of Huntington's disease. J Neurophysiol 2006; 95: 2108-2119.
48. Spampanato J, Gu X, Yang XW, Mody I: Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease. Neuroscience 2008; 157: 606-620.
49. Kolomiets B, Marzo A, Caboche J, Vanhoutte P, Otani S: Background dopamine concentration dependently facilitates longterm potentiation in rat prefrontal cortex through postsynaptic activation of extracellular signal-regulated kinases. Cereb Cortex 2009; 19: 2708-2718.
50. Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR: Inhibitors of metabolism rescue cell death in Huntington's disease models. Proc Natl Acad Sci USA 2007; 104: 14525-14530. (Pubitemid 350003294)