Risk factors of caregiver burden among patients with Alzheimer's disease or related disorders: A cross-sectional study

Journal of Alzheimer's Disease

Volumn 44, Issue 3, 2015, Pages 907-916

  Dauphinot, Virginie ^a   Delphin Combe, Floriane ^a   Mouchoux, Christelle ^a,b   Dorey, Aline ^a   Bathsavanis, Anthony ^a   Makaroff, Zaza ^a   Rouch, Isabelle ^a,c   Krolak Salmon, Pierre ^a,b  

^a HOSPICES CIVILS DE LYON   (France)

^b UNIVERSITÉ LYON 1   (France)

^c UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

Author keywords

Alzheimer's disease or related disorder; behavioral disorders; caregiver; dementia; dependency; elderly

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; HYPNOTIC SEDATIVE AGENT; NEUROLEPTIC AGENT; NOOTROPIC AGENT;

ACTIVITY OF DAILY LIVING ASSESSMENT; AGED; AGITATION; ALZHEIMER DISEASE; APATHY; APPETITE DISORDER; ARTICLE; BEHAVIOR DISORDER; CAREGIVER BURDEN; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; DEMENTIA; FEMALE; HUMAN; INDEPENDENCE; LOCOMOTION; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; PRIORITY JOURNAL; RISK FACTOR; VERY ELDERLY; CAREGIVER; COGNITION DISORDERS; COHORT ANALYSIS; DAILY LIFE ACTIVITY; NEUROPSYCHOLOGICAL TEST; OUTPATIENT; PSYCHOLOGY; STATISTICAL MODEL;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CAREGIVERS; COGNITION DISORDERS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LINEAR MODELS; MALE; NEUROPSYCHOLOGICAL TESTS; OUTPATIENTS; RISK FACTORS;

EID: 84922615228     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-142337     Document Type: Article

References (52)

1. Neuropathology Group of the Medical Research Council Cognitive Function, Ageing Study (MRC, CFAS) (2001) Pathological correlates of the late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 357, 169-175.
2. Bradaty H (2009) Family caregivers of people with dementia. Dialogues Clin Neurosci 11, 217-228.
3. Seeher K, Low L, Reppermund S, Brodaty H (2013) Predictors and outcomes for caregivers of people with mild cognitive impairment: A systematic literature review. Alzheimer Dement 9, 346-355.
4. Garand L, Dew M, Eazor L, DeKosky S, Reynolds Cr (2005) Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment. Int J Geriatr Psychiatry 20, 512-522.
5. Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M, Kastarinen M, Poulter N, Primatesta P, Rodriguez-Artalejo F, Stegmayr B, Thamm M, Tuomilehto J, Vanuzzo D, Vescio F (2003) Hypertension prevalence and blood pressure levels in 6 european countries, Canada and the United States. JAMA 289, 2363-2369.
6. Akkerman R, Ostwald S (2004) Reducing anxiety in Alzheimer's disease family caregivers: The effectiveness of nine-week cognitive-behavioral intervention. Am J Alzheimers Dis Other Demen 19, 117-123.
7. von Kanel R, Mausbach B, Patterson T, Dimsdale J, Aschbacher K, Mills P, Ziegler M, Ancoli-Israel S, Grant I (2008) Increased Framingham Coronary Heart Disease Risk Score in dementia caregivers relative to non-caregiving controls. Gerontology 54, 131-137.
8. Lee S, Colditz G, Berkman LF, Kawachi I (2003) Caregiving and risk of coronary heart disease in U. S. women: A prospective study. Am J Prev Med 24, 113-119.
9. Schulz R, Beach S (1999) Caregiving as a risk factor for mortality: The Caregiver Health Effects Study. JAMA 23, 2215-2219.
10. Schulz R, Belle S, Czaja S, McGinnis K, Stevens A, Zhang S (2004) Long-term care placement of dementia patients and caregiver health and well-being. JAMA 292, 961-967.
11. Graff M, Adang E, Vernooij-Dassen M, Dekker J, Jonsson L, Thijsen M, Hoefnagels W, Rikkert M (2008) Community occupational therapy for older patients with dementia and their care divers: Cost effectiveness study. BMJ 336, 134-138.
12. Callahan CM, Boustani M, Unverzagt F, Austrom M, Damush T, Perkins A, Fultz B, Hui S, Counsell S, Hendrie H (2006) Effectiveness of collaborative care for older adults with Alzheimer disease in primary care: A randomized controlled trial. JAMA 295, 2148-2157.
13. Wolfs C, Kessels A, Severens J, BrouwerW, de Vugt M, Verhey F, Dirksen C (2012) Predictive factors of the objective burden in informal care in people with dementia. Alzheimer Dis Assoc Disord 2, 197-204.
14. Torti F, Gwyther L, Reed S, Friedman J, SchulmanK(2004)A multinational review of recent trends and reports in dementia caregiver burden. Alzheimer Dis Assoc Disord 2004, 99-109.
15. Rosdinom R, Zarina M, Zanariah M, Marhani M, Suzaily W (2013) Behavioural and psychological symptoms of dementia, cognitive impairment and caregiver burden in patients with dementia. Prev Med 57, S67-S69.
16. Zarit S, Todd P, Zarit J (1986) Subjective burden of husbands and wives as caregivers: A longitudinal study. Gerontologist 26, 260-266.
17. Revel V, Haritchabalet I, Kervinio C, Drode M, Sauvanier M, Geny C, Placines B, Roux C, Albert D, De La Fournière F, Dartigues JF (2002) Construction d'une echelle simplifiee pour la detection en medecine generale du fardeau de l'aidant d'une personne agee dependante. L'annee Gerontol 16, 131-137.
18. Mckeith I, Cummings J (2005) Behavioural changes and psychological symptoms in dementia disorders. Lancet Neurol 4, 735-742.
19. Lawton MP, Brody EM (1969) Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist 9, 179-186.
20. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
21. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Peterson RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH (2011) The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institude on Aging-Alzheimer's Association workgroups on diagnosis guidelines for Alzheimer's disease. Alzheimers Dement 7, 270-279.
22. McKhann G, Knopman D, Chertkow H, Hyman B, Jack Cj, Kawas C, Klunk W, Koroshetz W, Manly J, Mayeux R, Mohs R, Morris J, Rossor M, Scheltens P, Carrillo M, Thies B, Weintraub S, Phelps CH (2011) The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association worgroups on diagnosis guidelines for Alzheimer's disease. Alzheimer Dement 7, 263-269.
23. Mckeith I, Dickson D, Lowe J, Emre M, O'Brien J, Feldman HH, Cummings J, Duda JE, Lippa C, Perry E, Aarsland D, Arai H, Ballard C, Boeve B, Burn D, Costa D, Del Ser T, Dubois B, GalaskoD, Gauthier S, Goetz C, Gomez-Tortosa E, Halliday G, Hansen L, Hardy J, Iwatsubo T, Kalaria R, Kaufer D, Kenny R, Korczyn A, Kosaka K, Lees A, Litvan I, Londos E, Lopez O, Minoshima S, Mizuno Y, Molina J, Mukaetova-Ladinska E, Pasquier F, Perry R, Schulz J, Trojanowski J, Yamada M (2005) Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium. Neurology 65, 1863-1872.
24. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A (1993) Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43, 250-260.
25. Rascovsky K, Hodges JR, Knopman D, Mendez M, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Grafman FM, Cappa J, Freedman SF, Grossman M, Miller M, BL (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134, 2456-2477.
26. Chuma Kraemer H, Stice E, Kazdin A, Offord D, Kupfer D (2001) How do risk factors work together? Mediators, moderators, and indepedent, overlapping, and proxy risk factors. Am J Psychiatry 158, 848-856.
27. Etters L, Goodall D, Harrison B (2008) Caregiver burden among dementia patient caregivers:Areviewof the litterature. J AM Acad Nurse Pract 20, 423-428.
28. Thommenssen B, Aarsland D, Braekhus A, Oksengaard A, Engedal K, Laake K (2007) The psychosocial burden on spouses of the elderly with stroke, dementia and Parkinson's disease. Int J Geriatr Psychiatry 17, 78-84.
29. Mohamed S, Rosenbeck R, Lyketsos C, Schneider L (2010) Caregiver burden in Alzheimer disease: Cross-sectional and longitudinal patient correlates. Am J Geriatr Psychiatry 18, 917-927.
30. Leinonen E, Korpisammal L, Pulkkinen L, Pukuri T (2001) The comparison of burden between caregiving spouses of depressive and demented patients. Int J Geriatr Psychiatry 16, 389-393.
31. Bedard M, Pedlar D, Martin N, Malott O, Stones M (2000) Burden in caregivers of cognitively impaired older adults living in the community: Methological issues and determinants. Int Psychogeriatr 12, 307-332.
32. Machnicki G, Allegri R, Dillon C, Serrano C, Taragono F (2009) Cognitive, functional and behavioral factors associated with the burden of caring for geriatric patients with cognitive impairment or depression: Evidence from a South American sample. Int J Geriatr Psychiatry 24, 383-389.
33. Riedijk SR, De Vugt ME, Duivenvoorden HJ, Niermeijer MF, Van Swieten JC, Verhey FR, Tibben A (2006) Caregiver burden, health-related quality of life and coping in dementia caregivers:Acomparison of frontotemporal dementia and Alzheimer's disease. Dement Geriatr Cogn Disord 22, 405-412.
34. Dunkin J, C, A-H (1998) Dementia caregiver burden: A review of the literature and guidelines for assessment and intervention. Neurology 51, S53-S60.
35. Teri L (2005) Behavior and caregiver burden: Behavioral problems in patients with Alzheimer disease and its association with caregiver distress. CNS Spectr 10, 481-488.
36. Bruce J, McQuiggan M,WilliamsV,Westervelt H, TremontG (2008) Burden among spousal and child caregivers of patients with mild cognitive impairment. Dement Geriatr Cogn Disord 25, 385-390.
37. Lim P, Sahadevan S, Choo G, Anthony P (1999) Burden of caregiving in mild to moderate dementia: An Asian experience. Int Psychogeriatr 11, 411-420.
38. Ryan K, Weldon A, Persad C, Heidebrink J, Barbas N, Giordani B (2012) Neuropsychiatric symptoms and executive functioning in patients with mild cognitive impairement: Relationship to cargiver burden. Dement Geriatr Cogn Disord 34, 206-215.
39. Agüera-Ortiz L, Frank-Garcia A, Gil P, Moreno A (2010) Clinical progression of moderate-to-severe Alzheimer's disease and caregiver burden: A 12-month multicenter prospective observational study. Int Psychogeriatr 22, 1265-1279.
40. Pang F, Chow T, Cummings J, Leung V, Chiu H, Lam L, Chen Q, Tai C, Chen L, Wang S, Fuh J (2002) Effect of neuropsychiatric symptoms of Alzheimer's disease on Chinese and American caregivers. Int J Geriatr Psychiatry 17, 29-34.
41. Robert PH, Berr C,VolteauM,Bertogliati-Fileau C, BenoitM, Guerin O, Sarazin M, Legrain S, Dubois B (2008) Importance of lack of interest in patients with mild cognitive impairment. Am J Geriatr Psychiatry 16, 770-776.
42. Ishii S, Weintraub N, Mervis JR (2009) Apathy: A common psychiatric syndrome in the elderly. J Am Med Dir Assoc 10, 381-393.
43. Robert PH, Mulin E, Mallea P, David R (2010) Review: Apathy diagnosis, assessment, and treatment in Alzheimer's disease. CNS Neurosci Ther 16, 263-271.
44. Ornstein K, Gaugler J (2012) The problem with "problem behaviors": A systematic review of the association between individual patient behavioral and psychological symptoms and caregiver depression and burden with the dementiacaregiver dyad. Int Psychogeriatr 24, 1536-1552.
45. Ornstein K, Gaugler J, Devanand D, Scarmeas N, Zhu C, Stern Y (2013) The differential impact of unique behavioral and psychological symptoms for the dementia caregiver: How and why do patients' individual symptom clusters impact caregiver depressive symptoms? Am J Geriatr Psychiatry 21, 1277-1286.
46. Benoit M, Berrut G, Doussaint J, Bakchine S, Bonin-Guillaume S, Fremont P, Gallarda T, Krolak-Salmon P, Marguet T, Mekies C, Sellal F, Schuck S, David R, Robert P (2012) Apathy and depression in mild Alzheimer's disease: A cross-sectional study using diagnostic criteria. J Alzheimer Dis 31, 325-334.
47. Barberger-Gateau P, Commenges D, Gagnon M, Letenneur L, Sauvel C, Dartigues JF (1992) Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers. J Am Geriatr Soc 40, 1129-1134.
48. Kim S, Kim J, Stewart R, Bae K, Yang S, Shin I, Shin H, Yoon J (2006) Correlates of caregiver burden for Korean elders according to cognitive and functional status. Int J Geriatr Psychiatry 21, 853-861.
49. Levy K, Lanctot K, Farber S, Li A, Herrmann N (2012) Does pharmacological treatment of neuropsychiatric symptoms in Alzheimer's disease relieve caregiver burden. Drugs Aging 29, 167-169.
50. Mohamed S, Rosenbeck R, Lyketsos C, Kaczynski R, Sultzer D, Schneider L (2012) Effect of second-generation antipsychotics on caregiver burden in Alzheimer's disease. J Clin Psychiatry 73, 121-128.
51. Black S, Doody R, Li H, McRae T, Jambor K, Xu Y, Sun Y, Perdomo C, Richardson S (2007) Donezepil preserves cognition and global function in patients with severe Alzheimer disease. Neurology 69, 459-469.
52. Annersted L, Elmstahl S, Ingvad B, Samuelsson S (2000) Family careviging in dementia-an analysis of the caregiver's burden and the "breaking-point" when home care becomes inadequate. Scand J Public Health 28, 23-31.