Importance of lack of interest in patients with mild cognitive impairment

American Journal of Geriatric Psychiatry

Volumn 16, Issue 9, 2008, Pages 770-776

  Robert, Philippe H ^a,e   Berr, Claudine ^c   Volteau, Magali ^b   Bertogliati Fileau, Christelle ^a   Benoit, Michel ^a   Guerin, Olivier ^a   Sarazin, Marie ^b   Legrain, Sylvie ^d   Dubois, Bruno ^b  

^a UNIVERSITY HOSPITAL OF NICE   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c INSERM   (France)

^d BICHAT HOSPITAL   (France)

^e University of Côte d'Azur   (France)

Author keywords

Alzheimer disease; Apathy; Diagnosis; Interest; Memory; Mild cognitive impairment

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; APATHY; ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MONTGOMERY ASBERG DEPRESSION RATING SCALE; NEUROPSYCHOLOGICAL TEST; RISK ASSESSMENT; AFFECT; ANXIETY DISORDER; ATTENTION; COGNITIVE DEFECT; DEPRESSION; HOSPITALIZATION; MIDDLE AGED; MOTIVATION; QUESTIONNAIRE;

AFFECT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANXIETY DISORDERS; ATTENTION; COGNITION DISORDERS; DEPRESSIVE DISORDER; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MOTIVATION; NEUROPSYCHOLOGICAL TESTS; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX;

EID: 59249095721     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1097/JGP.0b013e31817e73db     Document Type: Article

References (32)

1. Dubois B, Albert M: Amnestic MCI or prodromal Alzheimer's disease? Lancet Neurol 2004; 3:246-248
2. Lopez OL, Becker JT, Sweet RA: Non-cognitive symptoms in mild cognitive impairment subjects. Neurocase 2005; 11:65-71
3. Feldman H, Scheltens P, Scarpini E, et al: Behavioral symptoms in mild cognitive impairment. Neurology 2004; 62:1199-1201
4. Gabryelewicz T, Styczynska M, Pfeffer A, et al: Prevalence of major and minor depression in elderly persons with mild cognitive impairment - MADRS factor analysis. Int J Geriatr Psychiatry 2004; 19:1168-1172
5. Marin RS: Differential diagnosis and classification of apathy. Am J Psychiatry 1990; 147:22-30
6. Sarazin M, Berr C, De Rotrou J, et al: Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study. Neurology 2007; 69:1859-1867
7. Robert P, Berr C, Volteau M, et al: Neuropsychological performance in mild cognitive impairment with and without apathy. Dement Geriatr Cogn Disord 2006; 21:192-197
8. Robert PH, Berr C, Volteau M: Apathy in patients with mild cognitive impairment and the risk of developing dementia of Alzheimer's disease: a one-year follow-up study. Clin Neurol Neurosurg 2006; 108:733-736
9. Dartigues JF, Commenges D, Letenneur D, et al: Cognitive predictors of dementia in elderly community residents. Neuroepidemiology 1997; 16:29-39
10. Fabrigoule C, Rouch I, Taberly A, et al: Cognitive process in preclinical phase of dementia. Brain 1998; 121:135-141
11. Petersen RC, Smith GE, Waring SC, et al: Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999; 56:303-308
12. Folstein MF, Folstein SE, McHugh PR: "Mini-mental test." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
13. Isaacs B, Kennie AT: The Set test as an aid to the detection of dementia in old people. Br J Psychiatry 1973; 123:467-470
14. Grober E, Buschke H: Genuine memory deficits in dementia. Neuropsychology 1987; 3:13-36
15. Goldberg DP, Hillier VF: A scaled version of the General Health Questionnaire. Psychol Med 1979; 9:139-145
16. Montgomery S, Asberg M: A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134:382-389
17. Robert PH, Clairet S, Benoit M, et al: The apathy inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment. Int J Geriatr Psychiatry 2002; 17:1099-1105
18. Landes AM, Sperry SD, Strauss ME, et al: Apathy in Alzheimer's Disease. J Am Geriatr Soc 2001; 49:1700-1707
19. Starkstein SE, Petracca G, Chemerinski E, et al: Syndromic validity of apathy in Alzheimer's Disease. Am J Psychiatry 2001; 158:872- 877
20. Brocker P, Clairet S, Benoit M, et al: Inventaire Apathie: évaluation de l'apathie chez des sujets présentant une maladie d'Alzheimer ou un trouble cognitif léger. Revue de Gériatrie 2003; 28:473-480
21. McKhann G, Drachman D, Folstein M, et al: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984; 34:189-198
22. Modrego PJ Ferrandez J: Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type. Arch Neurol 2004; 61:1290-1293
23. Bartolini M, Coccia M, Luzzi S, et al: Motivational symptoms of depression mask preclinical Alzheimer's disease in elderly subjects. Dement Geriatr Cogn Disord 2005; 19:31-36
24. Berger AK, Fratiglioni, Forsell Y, et al: The occurrence of depressive symptoms in the preclinical phase of A.D. A populationbased study. Neurology 1999; 53:1998-2002
25. Wang J, Zhou D, Li J, et al: Leisure activity and the risk of cognitive impairment: the Chongquin aging study. Neurology 2006; 66:911-913
26. Fritsch T, Smith K, Debanne S, et al: Participation in novelty-seeking leisure activities and Alzheimer's Disease. J Geriatr Psychiatry Neurol 2005; 18:134-141
27. Verghese J, Lipton R, Katz M, et al: Leisure in novelty-seeking leisure activities and Alzheimer's Disease. N Engl J Med 2003; 348:2508-2516
28. Verghese J, Levalley A, Derby C, et al: Leisure activities and the risk of amnestic mild cognitive impairment in the elderly. Neurology 2006; 66:821-827
29. Stuss DT, Van Reekum R, Murphy KJ: Differentiation of States and Causes of Apathy. New York, Oxford University Press, 2000
30. Levy R, Dubois B: Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 2006; 16:916-928
31. Geda YE, Smith GE, Knopman DS, et al: De novo genesis of neuropsychiatric symptoms in mild cognitive impairment (MCI). Int Psychogeriatr 2004; 16:51-60
32. Hwang TJ, Masterman DL, Ortiz F, et al: Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Dis Assoc Disord 2004; 18:17-21